Nicolas M Van Mieghem

Medical Director


Thoraxcenter, Erasmus University Medical Center, Rotterdam, NL

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Prof Nicolas Maria Van Mieghem is an Interventional cardiologist at Thoraxcenter, Erasmus MC, Rotterdam, NL decided to pursue a career that would help others. “I enjoy the feeling of being able to help someone or do something important for them". His father was a general cardiologist and one of his biggest influences early in his career.

Prof Van Mieghem initially intended to train as a cardiac surgeon but decided to specialise in interventional cardiology instead, following advice from a mentor. This decision was cemented when he read the first-in-human case report of transcatheter aortic valve implantation (TAVI) in Circulation by Alain Cribier in 2002. Prof Van Mieghem believes that great cardiologist genuinely cares for their patients. He names Gary Roubin, Dr Manu Malbrain and Professor Patrick Serruys among his mentors. 

His current research focuses on cerebral embolic protection during TAVI and the search for improved large bore closure devices. He works actively in expanding TAVI indications, most notably TAVI as a means to further unload the left ventricle in heart failure patients with moderate aortic stenosis (the TAVR UNLOAD trial). Prof Van Mieghem is also involved in the development and dispersion of mechanical circulatory support (MCS) devices as well as transcatheter mitral and tricuspid repair techniques. In terms of imaging and preprocedural planning, his research has covered computed tomography (CT)-derived 3D modelling and printing.

As well as his involvement in percutaneous coronary interventions and structural heart programs, he has published and co-authored over 350 scientific papers in peer-reviewed journals. Professor Van Mieghem is a principal investigator and steering committee member in multiple ongoing international trials, evaluating various coronary and transcatheter valve technologies. He is a Fellow of the European Society of Cardiology (FESC) and is currently Medical Director of the department of Interventional cardiology at the Thorax Centre.

 Prof Van Mieghem is on the ICR3 Editorial Board.



Articles by Nicolas M Van Mieghem, Medical Director

Precision Medicine in Interventional Cardiology

Thijmen W Hokken, Joana M Ribeiro, Peter P De Jaegere, et al


Citation: Interventional Cardiology Review 2020;15:e03.

Aortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials

Ernest Spitzer, Rebecca T Hahn, Philippe Pibarot, et al


Citation: Cardiac Failure Review 2019;5(2):99–105.

Coronary Calcified Lesions: Introduction to the Focused Issue

Nicolas M Van Mieghem,


Citation: Interventional Cardiology Review 2019;14(3):152–3.

Large-bore Vascular Closure: New Devices and Techniques

Maarten P van Wiechen, Jurgen M Ligthart, Nicolas M Van Mieghem, et al


Citation: Interventional Cardiology Review 2019;14(1):17–21

The Role of Automated 3D Echocardiography for Left Ventricular Ejection Fraction Assessment

Ernest Spitzer, Ben Ren, Felix Zijlstra, et al

Citation: Cardiac Failure Review 2017;3(2):97–101.

Need for Embolic Protection During Transcatheter Aortic Valve Implantation: An Interventionalist’s Perspective on Histopathology Findings

Herbert G Kroon, Nicolas M Van Mieghem,

Citation: Interventional Cardiology Review 2017;12(1):36–9

Personal Experience with Bioresorbable Scaffolds in Bifurcations

Roberto Diletti, Nicolas M Van Mieghem,

Citation: Interventional Cardiology Review 2013;8(2):93-5

Cardiovascular Clinical Trials in a Pandemic: Immediate Implications of Coronavirus Disease 2019

Ernest Spitzer, Ben Ren, Jasper J Brugts, et al


Citation: Cardiac Failure Review 2020;6:e09.

A42 - Pressure and Volume Unloading with Pulsatile Circulatory Support During High-risk Percutaneous Revascularisation

MB Bastos, JJ Schreuder, Joost Daemen, et al


Citation: Interventional Cardiology Review 2019;14(3 Suppl 1):A42.