Nicolas M Van Mieghem

Nicolas M Van Mieghem

Full Professor of Interventional Cardiology

PhD FESC

Erasmus University Medical Center, Rotterdam, NL

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Biography

Prof Van Mieghem initially intended to train as a cardiac surgeon but decided to specialise in interventional cardiology instead, following advice from a mentor. This decision was cemented when he read the first-in-human case report of transcatheter aortic valve implantation (TAVI) in Circulation by Alain Cribier in 2002. Prof Van Mieghem believes that great cardiologist genuinely cares for their patients. He names Gary Roubin, Dr Manu Malbrain and Professor Patrick Serruys among his mentors. 

 

Academic History

Prof. Nicolas M. Van Mieghem completed his medical training at the Catholic University of Leuven (Belgium), where he earned both his medical degree and his specialist degree in cardiology. During his time in Leuven, he developed a strong interest in cardiovascular medicine, particularly in the emerging field of minimally invasive cardiac interventions. After finishing his core medical and cardiology training, he pursued multiple advanced fellowships in interventional cardiology, beginning at the Ziekenhuis Oost-Limburg in Genk, Belgium. Seeking broader expertise, he continued his fellowship training at Lenox Hill Hospital in New York, where he gained extensive experience in percutaneous coronary and structural heart procedures within a high-volume U.S. centre. He later completed a prestigious structural heart fellowship at the Thoraxcenter, Erasmus University Medical Center (Rotterdam, Netherlands), one of Europe’s leading institutions in transcatheter valve therapy.

Alongside his clinical training, Prof. Van Mieghem completed a PhD focused on transcatheter valve therapies, contributing early to the evidence base for aortic valve replacement via catheter-based approaches. His academic formation established him as a clinician–scientist with a strong foundation in both interventional practice and cardiovascular research methodology.

 

Career Overview

Prof. Van Mieghem began his senior clinical career at the Thoraxcenter, Erasmus MC, joining the Department of Interventional Cardiology in February 2010. In this role, he rapidly became involved in the centre’s expanding structural heart programme, performing complex percutaneous coronary interventions and helping to advance the adoption of transcatheter aortic valve implantation (TAVI). His expertise and leadership in interventional cardiology led to his appointment as Clinical Director / Medical Director of Interventional Cardiology in 2014, where he oversaw clinical operations, guided innovation in catheter-based therapies, and contributed to the Thoraxcenter’s reputation as a worldwide leader in structural heart disease.

Throughout the 2010s, he played a central role in numerous international clinical trials involving transcatheter valve replacement and repair, mechanical circulatory support devices, coronary atherectomy platforms, and novel vascular access technologies. His research, procedural experience, and mentorship earned him a reputation as one of Europe’s foremost figures in structural heart interventions. In recognition of his clinical and academic contributions, he was appointed Full Professor of Interventional Cardiology at Erasmus MC on 1 September 2019. Today, Prof. Van Mieghem continues to lead cutting-edge interventional programmes, contributing to device development, trial leadership, and procedural innovation, while training the next generation of interventional cardiologists.

Prof Van Mieghem is currently on the ICR3 Editorial Board.

 

Recognition & Contributions

  • Van Mieghem has published and co-authored over 350 scientific papers in peer-reviewed journals — with some sources from his institutional profile citing “over 600 scientific papers”
  • He is a Fellow of the European Society of Cardiology (FESC) and also of the American College of Cardiology (FACC)
  • He serves as a principal investigator and steering-committee member in multiple ongoing international clinical trials, evaluating various transcatheter valve technologies, mechanical circulatory support platforms, and coronary atherectomy devices
  • His research and clinical efforts have significantly advanced transcatheter valve therapies (e.g., TAVI/TAVR)making them safer, more widely applicable, and helping expand their indications beyond high-risk surgical candidates

 

Areas of Speciality / Research Focus

  • Transcatheter aortic valve implantation / replacement (TAVI/TAVR) & structural heart interventions
  • Percutaneous coronary interventions (PCI), with emphasis on calcified coronary lesions and complex revascularization
  • Mechanical circulatory support (MCS) in high-risk or complex cardiac patients
  • Novel large-bore vascular access closure techniques, including closure device development and vascular access management in structural interventions
  • Imaging and pre-procedural planning techniques, including CT-derived 3D modeling and printing to facilitate structural heart interventions (e.g., mitral/tricuspid repair)

 

References

Read more

Media

Ole De Backer, Nicolas M Van Mieghem

Watch time: 11m 57s (2 videos)
NVM Cardiology Meeting Reflections: AHA 25 Preview

Nicolas M Van Mieghem

Watch time: 14m 12s

Nicolas M Van Mieghem

Watch time: 14m 12s (23 videos)
NVM Cardiology Meeting Reflections: AHA 25 Preview

Nicolas M Van Mieghem

Watch time: 9m 56s
NVM Cardiology Meeting Reflections: What's Hot at TCT 25?

Nicolas M Van Mieghem

Watch time: 14m 58s
Expanding TAVI to Low- And Intermediate-Risk Patients

Nicolas M Van Mieghem, Joanna J Wykrzykowska, Giuseppe Tarantini, et al

Watch time: 27m 1s
View from the Thoraxcenter: ESC 25 Late-breaking Science Wrap-Up

Nicolas M Van Mieghem, Joost Daemen

Watch time: 47m 54s

Broadcast

Intervention
Transcatheter Interventions Online 2026 - Day Two

Nicolas M Van Mieghem, David Hildick-Smith, Roxana Mehran , et al

Broadcast

Intervention
Transcatheter Interventions Online 2026 - Day One

Nicolas M Van Mieghem, David Hildick-Smith, Roxana Mehran , et al

Nicolas M Van Mieghem, Joost Daemen

Watch time: 13m 42s
View from the Thoraxcenter: ESC 2025 Interventional Cardiology Preview

Nicolas M Van Mieghem, Joost Daemen

Watch time: 20m 32s

Nicolas M Van Mieghem

Watch time: 11m 48s (2 videos)
View from the Thoraxcenter: ESC Congress 25 Preview

Joost Daemen, Nicolas M Van Mieghem

Watch time: 36m 33s

Joost Daemen, Nicolas M Van Mieghem

Watch time: 5h 48m 39s (30 videos)
View from the Thoraxcenter: EuroPCR 25 Wrap Up

Joost Daemen, Nicolas M Van Mieghem

Watch time: 43m 36s

Joost Daemen, Nicolas M Van Mieghem

Watch time: 2h 27m 56s (15 videos)
View from the Thoraxcenter: EuroPCR 25 Late-breaking Preview

Joost Daemen, Nicolas M Van Mieghem

Watch time: 26m 38s
View from the Thoraxcenter: ACC 25 Wrap Up

Joost Daemen, Nicolas M Van Mieghem

Watch time: 39m 2s

Joost Daemen, Nicolas M Van Mieghem

Watch time: 39m 2s (21 videos)
View from the Thoraxcenter: What's Hot at ACC.25?

Joost Daemen, Nicolas M Van Mieghem

Watch time: 30m 45s
View from the Thoraxcenter: AHA 24 Wrap-Up

Joost Daemen, Nicolas M Van Mieghem

Watch time: 17m 38s
TCT 24 Late-breaking Science Wrap Up

Joost Daemen, Nicolas M Van Mieghem

Watch time: 48m 41s
TCT 24: The TAVR UNLOAD Trial

Nicolas M Van Mieghem

Watch time: 4m 10s

Joost Daemen, Nicolas M Van Mieghem

View from the Thoraxcenter: What's Hot at AHA 24?

Joost Daemen, Nicolas M Van Mieghem

Watch time: 13m 43s
View from the Thoraxcenter: What's Hot at TCT 24?

Nicolas M Van Mieghem, Joost Daemen

Watch time: 38m 7s
View from the Thoraxcenter: ESC 24 Hot Line Science Wrap Up

Nicolas M Van Mieghem, Joost Daemen

Watch time: 47m 31s

Broadcast

Intervention
Transcatheter Interventions Online 2025 - Day Four

Ajay J Kirtane, Azeem Latib, Eric Secemsky , et al

Broadcast

Intervention
Transcatheter Interventions Online 2025 - Day Three

Nicolas M Van Mieghem, David Hildick-Smith, Roxana Mehran , et al

Broadcast

Intervention
Transcatheter Interventions Online 2025 - Day Two

Nicolas M Van Mieghem, David Hildick-Smith, Roxana Mehran , et al

Broadcast

Intervention
Transcatheter Interventions Online 2025 - Day One

Nicolas M Van Mieghem, David Hildick-Smith, Roxana Mehran , et al

View from the Thoraxcenter: ESC Congress 24 Hot Line Preview

Nicolas M Van Mieghem, Joost Daemen

Watch time: 27m 27s
View from the Thoraxcenter: EuroPCR 24 Wrap Up - Part 1

Nicolas M Van Mieghem, Joost Daemen

Watch time: 18m 29s
View from the Thoraxcenter: What's Hot at EuroPCR 24?

Nicolas M Van Mieghem, Joost Daemen

Watch time: 26m 3s
View from the Thoraxcenter: ACC.24 Late-breaking Science Wrap Up

Nicolas M Van Mieghem, Joost Daemen

Watch time: 43m 48s
Exploring the Potential of Sensor-Guided TAVI

Nicolas M Van Mieghem, Danny Dvir, Ander Regueiro, et al

View from the Thoraxcenter: What's Hot at ACC.24?

Nicolas M Van Mieghem, Joost Daemen

Watch time: 28m 9s

Nicolas M Van Mieghem, Ajay J Kirtane, Holger Thiele, et al

Broadcast

Imaging & Diagnostics

Intervention
iPCI Meeting 2024 - Day 1

Joost Daemen, Gijs van Soest, Kalaivani Mahadevan , et al

Nicolas M Van Mieghem, Federico Pappalardo, Divaka Perera, et al

Watch time: 1s (2 videos)

Nicolas M Van Mieghem, Giuseppe Tarantini, Alaide Chieffo, et al

Watch time: 50m (5 videos)
View from the Thoraxcenter: AHA 23 Late-breaking Science Wrap Up

Nicolas M Van Mieghem, Joost Daemen

Watch time: 23m 13s
View from the Thoraxcenter: AHA 23 Wrap Up

Nicolas M Van Mieghem, Joost Daemen,

Listen time: 23m 14s
View from the Thoraxcenter: AHA 23 Wrap Up

Nicolas M Van Mieghem,

Listen time: 23m 14s
View from the Thoraxcenter: AHA 23 Late-breaking Science Preview

Nicolas M Van Mieghem, Joost Daemen

Watch time: 12m 34s
View from the Thoraxcenter: TCT 23 Late-breaking Science Wrap Up

Nicolas M Van Mieghem, Joost Daemen

Watch time: 30m 36s
View from the Thoraxcenter: TCT 23 Wrap Up

Nicolas M Van Mieghem, Joost Daemen,

Listen time: 30m 37s
View from the Thoraxcenter: TCT 23 Late-breaking Science Preview

Joost Daemen, Nicolas M Van Mieghem

Watch time: 25m 48s

Broadcast

Intervention
TIO Mechanical Circulatory Support 2023

Nicolas M Van Mieghem, Holger Thiele, Giuseppe Tarantini , et al

ESC 23 Late-breaking Science Wrap Up

Nicolas M Van Mieghem, Joost Daemen,

Listen time: 47m 56s

Articles by Nicolas M Van Mieghem, Full Professor of Interventional Cardiology

Incidence and Pathology of Aortic Regurgitation

Lucas Uchoa de Assis, Giulio M Mondellini, Mark MP van den Dorpel, et al

Published:

Citation: Interventional Cardiology 2025;20:e07.

DOI:

https://doi.org/10.15420/icr.2024.37
Conduction Abnormalities after Transcatheter Aortic Valve Implantation: Incidence, Impact and Management Using CT Data Interpretation

Rutger-Jan Nuis, Mark van den Dorpel, Rik Adrichem, et al

Published:

Citation: Interventional Cardiology 2024;19:e12.

DOI:

https://doi.org/10.15420/icr.2024.11
Precision Medicine in Interventional Cardiology

Thijmen W Hokken, Joana M Ribeiro, Peter P De Jaegere, et al

Published:

Citation: Interventional Cardiology Review 2020;15:e03.

DOI:

https://doi.org/10.15420/icr.2019.23
Aortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials

Ernest Spitzer, Rebecca T Hahn, Philippe Pibarot, et al

Published:

Citation: Cardiac Failure Review 2019;5(2):99–105.

DOI:

https://doi.org/10.15420/cfr.2018.41.2
Coronary Calcified Lesions: Introduction to the Focused Issue

Nicolas M Van Mieghem,

Published:

Citation: Interventional Cardiology Review 2019;14(3):152–3.

DOI:

https://doi.org/10.15420/icr.2019.14.3.GE1
Large-bore Vascular Closure: New Devices and Techniques

Maarten P van Wiechen, Jurgen M Ligthart, Nicolas M Van Mieghem, et al

Published:

Citation: Interventional Cardiology Review 2019;14(1):17–21

DOI:

https://doi.org/10.15420/icr.2018.36.1
The Role of Automated 3D Echocardiography for Left Ventricular Ejection Fraction Assessment

Ernest Spitzer, Ben Ren, Felix Zijlstra, et al

Citation: Cardiac Failure Review 2017;3(2):97–101.

DOI:

https://doi.org/10.15420/cfr.2017:14.1
Need for Embolic Protection During Transcatheter Aortic Valve Implantation: An Interventionalist’s Perspective on Histopathology Findings

Herbert G Kroon, Nicolas M Van Mieghem,

Citation: Interventional Cardiology Review 2017;12(1):36–9

DOI:

https://doi.org/10.15420/icr.2016:30:2
Personal Experience with Bioresorbable Scaffolds in Bifurcations

Roberto Diletti, Nicolas M Van Mieghem,

Citation: Interventional Cardiology Review 2013;8(2):93-5

DOI:

https://doi.org/10.15420/icr.2013.8.2.93
Cardiovascular Clinical Trials in a Pandemic: Immediate Implications of Coronavirus Disease 2019

Ernest Spitzer, Ben Ren, Jasper J Brugts, et al

Published:

Citation: Cardiac Failure Review 2020;6:e09.

DOI:

https://doi.org/10.15420/cfr.2020.07
A42 - Pressure and Volume Unloading with Pulsatile Circulatory Support During High-risk Percutaneous Revascularisation

MB Bastos, JJ Schreuder, Joost Daemen, et al

Published:

Citation: Interventional Cardiology Review 2019;14(3 Suppl 1):A42.

DOI:

https://doi.org/10.15420/icr.2019.14.3.S1