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Cardiomyopathy

Welcome to our featured section on cardiomyopathy

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This educational hub pulls together the latest clinical data, guidelines, congress updates as well as original video content and expert interviews on the management of cardiomyopathies. Some of the content on this hub will be CME-accredited and credits will be available when viewed on Radcliffe Medical Education – our dedicated CME portal. Instructions on how to do so are provided with individual videos.

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Recent Videos

Video

AHA 22 Late-Breaking Science Highlights With Dr Joseph Hill

Joseph A Hill,

Watch time: 5m 4s

Video

AHA 22: Results of the CRISPR-Cas9 First-in-Human Trial

Julian Gillmore,

Watch time: 8m 12s

View from the Thoraxcenter: AHA 22 Late-breaking Science Preview

Video

View from the Thoraxcenter: What's Hot at AHA 2022?

Nicolas M Van Mieghem, Joost Daemen,

Watch time: 15m 30s

HFSA 22: REDWOOD-HCM OLE: KCCQ Scores In Pts With HCM Treated With Aficamten

Video

HFSA 22: KCCQ Scores In Pts With HCM Treated With Aficamten

Sara Saberi,

Watch time: 15m 24s

Video Series

HCM in Review: Assessing SCD Risk in HCM & Managing HCM With High Risk SCD

Perry Elliott,

Watch time: 18m 30s (2 videos)

Broadcast

Valsartan Sacubitril: Has our PARADIGM shifted?

Giuseppe Rosano, Richard Henry P Tiongco, Rungroj Krittayaphong, et al

Clinical publications

Association of pathogenic DNA variants predisposing to cardiomyopathy with cardiovascular disease outcomes and all-cause mortality

Patel AP, Dron JS, Wang M, et al. JAMA Cardiol 2022;7:723–32.

Rare and common genetic variation underlying the risk of hypertrophic cardiomyopathy in a national biobank

Biddinger KJ, Jurgens SJ, Maamari D, et al. JAMA Cardiol 2022;7:715–22.

High-throughput precision phenotyping of left ventricular hypertrophy with cardiovascular deep learning

Duffy G, Cheng PP, Yuan N, et al. JAMA Cardiol 2022;7:386–95.

Percutaneous intramyocardial septal radiofrequency ablation in patients with drug-refractory hypertrophic obstructive cardiomyopathy

Zhou M, Ta S, Hahn RT, et al. JAMA Cardiol 2022;7:529–38.

Muscle LIM protein force-sensing mediates sarcomeric biomechanical signaling in human familial hypertrophic cardiomyopathy

Riaz M, Park J, Sewanan LR, et al. Circulation 2022;145:1238–53.

Association of septal myectomy with quality of life in patients with left ventricular outflow tract obstruction from hypertrophic cardiomyopathy

Desai MY, Tower-Rader A, Szpakowski N, et al. JAMA Netw Open 2022;5:e227293.

Assessment of disease status and treatment response with artificial intelligence−enhanced electrocardiography in obstructive hypertrophic cardiomyopathy

Tison GH, Siontis KC, Abreau S, et al. J Am Coll Cardiol 2022;79:1032–4.

Survival following alcohol septal ablation or septal myectomy for patients with obstructive hypertrophic cardiomyopathy

Cui H, Schaff HV, Wang S, et al. J Am Coll Cardiol 2022;79:1647–55.

Clinical features and natural history of preadolescent nonsyndromic hypertrophic cardiomyopathy

Norrish G, Cleary A, Field E, et al. J Am Coll Cardiol 2022;79:1986–97.

Effects of metoprolol on exercise hemodynamics in patients with obstructive hypertrophic cardiomyopathy

Dybro AM, Rasmussen TB, Nielsen RR, et al. J Am Coll Cardiol 2022;79:1565–75.

Impact of autophagy on prognosis of patients with dilated cardiomyopathy

Kanamori H, Yoshida A, Naruse G, et al. J Am Coll Cardiol 2022;79:789–801.

Long-term cardiovascular outcomes of COVID-19

Xie Y, Xu E, Bowe B, Al-Aly Z. Nat Med 2022;28:583–90.

Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry

Jackson AM, Petrie MC, Frogoudaki A, et al. Eur J Heart Fail 2021;23:2058–69.

Phenotypic expression, natural history, and risk stratification of cardiomyopathy caused by filamin C truncating variants

Gigli M, Stolfo D, Graw SL, et al. Circulation 2021;144:1600–11.

Altered cardiac energetics and mitochondrial dysfunction in hypertrophic cardiomyopathy

Ranjbarvaziri S, Kooiker KB, Ellenberger M, et al. Circulation 2021;144:1714–31.

Association between sarcomeric variants in hypertrophic cardiomyopathy and myocardial oxygenation: insights from a novel oxygen-sensitive cardiovascular magnetic resonance approach

Raman B, Tunnicliffe EM, Chan K, et al. Circulation 2021;144:1656–8.

Effect of mavacamten on echocardiographic features in symptomatic patients with obstructive hypertrophic cardiomyopathy

Hegde SM, Lester SJ, Solomon SD, et al. J Am Coll Cardiol 2021;78:2518–32.

Randomized trial of metoprolol in patients with obstructive hypertrophic cardiomyopathy

Dybro AM, Rasmussen TB, Nielsen RR, et al. J Am Coll Cardiol 2021;78:2505–17.

Acute myocarditis following COVID-19 mRNA vaccination in adults aged 18 years or older

Simone A, Herald J, Chen A, et al. JAMA Intern Med 2021;181:1668–70.

Role of plakophilin-2 expression on exercise-related progression of arrhythmogenic right ventricular cardiomyopathy: a translational study

Cerrone M, Marrón-Liñares GM, van Opbergen CJM, et al. Eur Heart J 2022;43:1251–64.

SARS-CoV-2 vaccination and myocarditis or myopericarditis: population based cohort study

Husby A, Hansen JV, Fosbøl E, et al. BMJ 2021;375:e068665.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021

Oster ME, Shay DK, Su JR, et al. JAMA 2022;327:331–40.

Prevalence and cumulative risk of familial idiopathic dilated cardiomyopathy

Huggins GS, Kinnamon DD, Haas GJ, et al. JAMA 2022;327:454–63.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection

Patone M, Mei XW, Handunnetthi L, et al. Nat Med 2022;28:410–22.

Myocarditis after BNT162b2 mRNA vaccine against covid-19 in Israel

Mevorach D, Anis E, Cedar N, et al. N Engl J Med 2021;385:2140–9.

Myocarditis after covid-19 vaccination in a large health care organization

Witberg G, Barda N, Hoss S, et al. N Engl J Med 2021;385:2132–9.

Long-term risk of sudden cardiac death in hypertrophic cardiomyopathy: a cardiac magnetic resonance outcome study

Greulich S, Seitz A, Herter D, et al. Eur Heart J Cardiovasc Imaging 2021;22:732–41.

Catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy: a European observational multicentre study

Creta A, Elliott P, Earley MJ, et al. Europace 2021;23:1409–17.

Echocardiographic characteristics of severe left ventricular outflow tract obstruction in hypertrophic cardiomyopathy

Jain CC, Miranda WR, Geske JB, et al. J Am Soc Echocardiogr 2021;34:798–801.

Left atrial strain and function in pediatric hypertrophic cardiomyopathy

Jhaveri S, Komarlu R, Worley S, et al. J Am Soc Echocardiogr 2021;34:996–1006.

Sleep disordered breathing and mortality in patients with hypertrophic obstructive cardiomyopathy undergoing septal myectomy

Cui H, Schaff HV, Somers VK, et al. Mayo Clin Proc 2021;96:2323–31.

Alcohol septal ablation for hypertrophic cardiomyopathy through an anomalous septal perforator off the right cusp

Mahowald MK, Corban MT, Eleid MF, Nishimura RA. JACC Cardiovasc Interv 2021;14:e129–30.

Veselka J, Faber L, Liebregts M, et al. JACC Cardiovasc Interv 2021;14:1390–2.

Computational prediction of protein subdomain stability in MYBPC3 enables clinical risk stratification in hypertrophic cardiomyopathy and enhances variant interpretation

Thompson AD, Helms AS, Kannan A, et al. Genet Med 2021;23:1281–7.

Association of physical activity with all-cause and cardiovascular mortality in 7666 adults with hypertrophic cardiomyopathy (HCM): more physical activity is better

Kwon S, Lee HJ, Han KD, et al. Br J Sports Med 2021;55:1034–40.

Alpha-protein kinase 3 (ALPK3) truncating variants are a cause of autosomal dominant hypertrophic cardiomyopathy

Lopes LR, Garcia-Hernández S, Lorenzini M, et al. Eur Heart J 2021;42:3063–73.

Worldwide differences in primary prevention implantable cardioverter defibrillator utilization and outcomes in hypertrophic cardiomyopathy

Nauffal V, Marstrand P, Han L, et al. Eur Heart J 2021;42:3932–44.

Myocarditis and pericarditis after vaccination for COVID-19

Diaz GA, Parsons GT, Gering SK, et al. JAMA 2021;326:1210–2.

Surveillance for adverse events after COVID-19 mRNA vaccination

Klein NP, Lewis N, Goddard K, et al. JAMA 2021;326:1390–9.

Patterns of replacement fibrosis in hypertrophic cardiomyopathy

Liu J, Zhao S, Yu S, et al. Radiology 2021; epub ahead of press.

Safety of the BNT162b2 mRNA covid-19 vaccine in a nationwide setting

Barda N, Dagan N, Ben-Shlomo Y, et al. N Engl J Med 2021;385:1078–90.

MiRNAs as biomarkers in hypertrophic cardiomyopathy: current state of the art

Angelopoulos A, Oikonomou E, Vogiatzi G, et al. Curr Med Chem 2021; epub ahead of press.

Alcohol dose in septal ablation for hypertrophic obstructive cardiomyopathy

Veselka J, Faber L, Liebregts M, et al. Int J Cardiol 2021;333:127–32.

Ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy: treatment strategy, characteristics of consecutive atrial tachycardia and long‐term outcome

Dinshaw L, Münkler P, Schäffer B, et al. J Am Heart Assoc 2021;10:e017451.

Does ablation of atrial fibrillation at the time of septal myectomy improve survival of patients with obstructive hypertrophic cardiomyopathy?

Cui H, Schaff HV, Dearani JA, et al. J Thorac Cardiovasc Surg 2021;161:997–1006.e3.

Mutations in myosin S2 alter cardiac myosin-binding protein-C interaction in hypertrophic cardiomyopathy in a phosphorylation-dependent manner

Singh RR, McNamara JW, Sadayappan S. J Biol Chem 2021;297:100836.

Prevalence and clinical correlates of aortic dilation in hypertrophic cardiomyopathy

Geske JB, Nordhues BD, Orme NM, et al. J Am Soc Echocardiogr 2021;34:279–85.

Increased heart rate with sleep disordered breathing in hypertrophic cardiomyopathy

Konecny T, Khoo M, Covassin N, et al. Int J Cardiol 2021;323:155–60.

Matrix metalloproteinases increase because of hypoperfusion in obstructive hypertrophic cardiomyopathy

Bi X, Yang C, Song Y, et al. Ann Thorac Surg 2021;111:915–22.

A systematic review of microRNAs in patients with hypertrophic cardiomyopathy

Scolari FL, Faganello LS, Garbin HI, et al. Int J Cardiol 2021;327:146–54.

Dynamic thiol/disulphide homeostasis in patients with hypertrophic cardiomyopathy

Sari M, Erkorkmaz U, Yazar H, et al. Herz 2021;46:164–71.

Prognostic impact of atrial fibrillation in hypertrophic cardiomyopathy: a systematic review

Alphonse P, Virk S, Collins J, et al. Clin Res Cardiol 2021;110:544–54.

Anticoagulation for stroke prevention in patients with hypertrophic cardiomyopathy and atrial fibrillation: a review

Nasser MF, Gandhi S, Siegel RJ, Rader F. Heart Rhythm 2021;18:297–302.

Transapical septal myectomy for hypertrophic cardiomyopathy with midventricular obstruction

Sun D, Schaff HV, Nishimura RA, et al. Ann Thorac Surg 2021;111:836–44.

Arrhythmias and conduction disturbances in autoimmune rheumatic disorders

Plastiras SC, Moutsopoulos HM. Arrhythm Electrophysiol Rev 2021;10:17–25.

Coronavirus disease 2019: cardiac complications and considerations for returning to sports participation

Augustine DX, Keteepe-Arachi T, Malhotra A. Eur Cardiol 2021;16:e03.

Direct oral anticoagulants in Asian patients with atrial fibrillation: consensus recommendations by the Asian Pacific Society of Cardiology on strategies for thrombotic and bleeding risk management

Chong DTT, Andreotti F, Verhamme P, et al. Eur Cardiol 2021;16:e23.

Electrocardiographic criteria for differentiating left from right idiopathic outflow tract ventricular arrhythmias

Mariani MV, Piro A, Della Rocca DG, et al. Arrhythm Electrophysiol Rev 2021;10:10–6.

Bridging the gap in a rare cause of angina

Khadke S, Vidovic J, Patel V. Eur Cardiol 2021;16:e05.

Mavacamten favorably impacts cardiac structure in obstructive hypertrophic cardiomyopathy: EXPLORER-HCM cardiac magnetic resonance substudy analysis

Saberi S, Cardim N, Yamani M, et al. Circulation 2021;143:606–8.

Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure

Teerlink JR, Diaz R, Felker GM, et al. N Engl J Med 2021;384:105–16.

Mavacamten: treatment aspirations in hypertrophic cardiomyopathy

Papadakis M, Basu J, Sharma S. Lancet 2020;396:736–7.

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial

Olivotto I, Oreziak A, Barriales-Villa R, et al. Lancet 2020;396:759–69.

Outcomes in patients with hypertrophic cardiomyopathy and left ventricular systolic dysfunction

Rowin EJ, Maron BJ, Carrick RT, et al. J Am Coll Cardiol 2020;75:3033–43.

Penetrance of hypertrophic cardiomyopathy in sarcomere protein mutation carriers

Lorenzini M, Norrish G, Field E, et al. J Am Coll Cardiol 2020;76:550–9.

Evaluation of mavacamten in symptomatic patients with nonobstructive hypertrophic cardiomyopathy

Ho CY, Mealiffe ME, Bach RG, et al. J Am Coll Cardiol 2020;75:2649–60.

Distinct subgroups in hypertrophic cardiomyopathy in the NHLBI HCM Registry

Neubauer S, Kolm P, Ho CY, et al. J Am Coll Cardiol 2019;74:2333–45.

Detection of hypertrophic cardiomyopathy using a convolutional neural network-enabled electrocardiogram

Ko WY, Siontis KC, Attia ZI, et al. J Am Coll Cardiol 2020;75:722–33.

Association of hypertrophic obstructive cardiomyopathy with outcomes following transcatheter aortic valve replacement

Bandyopadhyay D, Chakraborty S, Amgai B, et al. JAMA Netw Open 2020;3:e1921669.

Incidence of stress cardiomyopathy during the coronavirus disease 2019 pandemic

Jabri A, Kalra A, Kumar A, et al. JAMA Netw Open 2020;3:e2014780.

Efficacy and safety of tafamidis doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR‐ACT) and long‐term extension study

Damy T, Garcia-Pavia P, Hanna M, et al. Eur J Heart Fail 2020; epub ahead of press.

Biventricular pacemaker therapy improves exercise capacity in patients with non‐obstructive hypertrophic cardiomyopathy via augmented diastolic filling on exercise

Ahmed I, Loudon BL, Abozguia K, et al. Eur J Heart Fail 2020;22:1263–72.

Advanced imaging insights in apical hypertrophic cardiomyopathy

Hughes RK, Knott KD, Malcolmson J, et al. JACC Cardiovasc Imaging 2020;13:624–30.

Clinical outcomes in adult athletes with hypertrophic cardiomyopathy: a 7-year follow-up study

Pelliccia A, Caselli S, Pelliccia M, et al. Br J Sports Med 2020;54:1008–12.

Development of a novel risk prediction model for sudden cardiac death in childhood hypertrophic cardiomyopathy (HCM Risk-Kids)

Norrish G, Ding T, Field E, et al. JAMA Cardiol 2019;4:918–27.

Association of race with disease expression and clinical outcomes among patients with hypertrophic cardiomyopathy

Eberly LA, Day SM, Ashley EA, et al. JAMA Cardiol 2020;5:83–91.

Mortality among referral patients with hypertrophic cardiomyopathy vs the general European population

Lorenzini M, Anastasiou Z, O’Mahony C, et al. JAMA Cardiol 2020;5:73–80.

Association of obesity with adverse long-term outcomes in hypertrophic cardiomyopathy

Fumagalli C, Maurizi N, Day SM, et al. JAMA Cardiol 2020;5:65–72.

Undetermined stroke genesis and hidden cardiomyopathies determined by cardiac magnetic resonance

Fonseca AC, Marto JP, Pimenta D, et al. Neurology 2020;94:e107–13.

Study design and rationale of EXPLORER-HCM: evaluation of mavacamten in adults with symptomatic obstructive hypertrophic cardiomyopathy

Ho CY, Olivotto I, Jacoby D, et al. Circ Heart Fail 2020;13.

Risk stratification in cardiomyopathy

Sinagra G, Carriere C, Clemenza F, et al. Eur J Prev Cardiol 2020;27:52–8.

Access and outcomes among hypertrophic cardiomyopathy patients in a large integrated health system

Thomas A, Papoutsidakis N, Spatz E, et al. J Am Heart Assoc 2020;9.

Myocardial contraction fraction predicts mortality for patients with hypertrophic cardiomyopathy

Liao H, Wang Z, Zhao L, et al. Sci Rep 2020;10:17026.

Left ventricular global function index by magnetic resonance imaging — a novel marker for differentiating cardiac amyloidosis from hypertrophic cardiomyopathy

Huang S, Xu HY, Diao KY, et al. Sci Rep 2020;10:4707.

Implantable cardioverter defibrillators in patients with electrical heart disease and hypertrophic cardiomyopathy: data from the German device registry

Frommeyer G, Reinke F, Andresen D, et al. Clin Res Cardiol 2020;109:508–12.

Hypertrophic cardiomyopathy - a heterogeneous and lifelong disease in the real world

Kitaoka H, Kubo T, Doi YL. Circ J 2020;84:1218–26.

Comparison of expected and observed outcomes for septal myectomy in hypertrophic obstructive cardiomyopathy

Geske JB, Driver CN, Yogeswaran V, et al. Am Heart J 2020;221:159–64.

Sex-specific cardiac phenotype and clinical outcomes in patients with hypertrophic cardiomyopathy

Lu DY, Ventoulis I, Liu H, et al. Am Heart J 2020;219:58–69.

Guidelines

Perioperative implications of the 2020 American Heart Association/American College of Cardiology guidelines for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a focused review

Addis DR, Townsley MM. J Cardiothorac Vasc Anesth 2022;36:2143–53.

Prognostic relevance of a score for identifying diastolic dysfunction according to the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging recommendations in patients with hypertrophic cardiomyopathy

Saito C, Minami Y, Haruki S, et al. J Am Soc Echocardiogr 2022;35:469–76.

Recommendations for multimodality cardiovascular imaging of patients with hypertrophic cardiomyopathy

Nagueh SF, Phelan D, Abraham T, et al. J Am Soc Echocardiogr 2022;35:533–69.

Validation of the new American College of Cardiology/American Heart Association Guidelines for the risk stratification of sudden cardiac death in a large Mediterranean cohort with hypertrophic cardiomyopathy

Zegkos T, Tziomalos G, Parcharidou D, et al. Hellenic J Cardiol 2022;63:15–21.

Process of care and a practical toolkit for evaluating and managing arrhythmic risk in the cardiogenetic pregnant patient

Cheung CC, Roston TM, Davies B, et al. Can J Cardiol 2021;37:2001–13.

Comparing clinical performance of current implantable cardioverter-defibrillator implantation recommendations in arrhythmogenic right ventricular cardiomyopathy

Bosman LP, Nielsen Gerlach CL, Cadrin-Tourigny J, et al. Europace 2022;24:296–305.

2021: The American Association for Thoracic Surgery Expert Consensus Document: coronary artery bypass grafting in patients with ischemic cardiomyopathy and heart failure

Bakaeen FG, Gaudino M, Whitman G, et al. J Thorac Cardiovasc Surg 2021;162:829–50.e1.

The wait is over: the 2020 American Heart Association/American College of Cardiology (AHA/ACC) hypertrophic cardiomyopathy guidelines have arrived

Semsarian C, Davis L. Heart Lung Circ 2021;30:465–8.

Recommendations of the current guidelines for implantable cardioverter-defibrillator implantation in patients with hypertrophic cardiomyopathy: debate still exists

Aminorroaya A, Vasheghani-Farahani A, Masoudkabir F, Roayaei P. J Interv Card Electrophysiol 2021;60:1–7.

Guidelines on the verge of a more evidence-based era for hypertrophic cardiomyopathy

Ho CY. Circulation 2021;143:295–7.

2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Writing Committee Members, Ommen SR, Mital S, et al. J Thorac Cardiovasc Surg 2021;162:e23–106.

2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology/American Heart Association joint committee on clinical practice guidelines

Writing Committee Members, Ommen SR, Mital S, et al. Circulation 2020;142:e533–57.

Clarification of the Australian heart failure guideline recommendation for primary prevention defibrillator implantation in non‐ischaemic cardiomyopathy

Kistler PM, Atherton JJ, Jennings G. Med J Aust 2020;212:509–510.e1.

Genetic testing for inherited cardiovascular diseases: a scientific statement from the American Heart Association

Musunuru K, Hershberger RE, Day SM, et al. Circ Genom Precis Med 2020;13:e000067.

Review Articles

Targeting the sarcomere in inherited cardiomyopathies

Lehman SJ, Crocini C, Leinwand LA. Nat Rev Cardiol 2022;19:353–63.

Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus

Raman B, Bluemke DA, Lüscher TF, Neubauer S. Eur Heart J 2022;43:1157–72.

Hypertrophic cardiomyopathy: new concepts and therapies

Maron BJ, Rowin EJ, Maron MS. Annu Rev Med 2022;73:363–75.

Inflammation and immune response in arrhythmogenic cardiomyopathy: state-of-the-art review

Asatryan B, Asimaki A, Landstrom AP, et al. Circulation 2021;144:1646–55.

Heart failure subtypes and cardiomyopathies in women

DeFilippis EM, Beale A, Martyn T, et al. Circ Res 2022;130:436–54.

The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

Ning Q, Wu D, Wang X, et al. Signal Transduct Target Ther 2022;7:57.

Associations of race and ethnicity with presentation and outcomes of hypertrophic cardiomyopathy: JACC focus seminar 6/9

Ntusi NAB, Sliwa K. J Am Coll Cardiol 2021;78:2573–9.

Impact of racial and ethnic disparities on patients with dilated cardiomyopathy: JACC focus seminar 7/9

Ntusi NAB, Sliwa K. J Am Coll Cardiol 2021;78:2580–8.

Diagnosis and evaluation of hypertrophic cardiomyopathy: JACC state-of-the-art review

Maron BJ, Desai MY, Nishimura RA, et al. J Am Coll Cardiol 2022;79:372–89.

Management of hypertrophic cardiomyopathy: JACC state-of-the-art review

Maron BJ, Desai MY, Nishimura RA, et al. J Am Coll Cardiol 2022;79:390–414.

Echocardiographic deformation imaging for early detection of genetic cardiomyopathies: JACC review topic of the week

Taha K, Kirkels FP, Teske AJ, et al. J Am Coll Cardiol 2022;79:594–608.

Minor hypertrophic cardiomyopathy genes, major insights into the genetics of cardiomyopathies

Walsh R, Offerhaus JA, Tadros R, Bezzina CR. Nat Rev Cardiol 2022;19:151–67.

Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms

Heymans S, Cooper LT. Nat Rev Cardiol 2022;19:75–7.

Myocardial revascularization in ischaemic cardiomyopathy: routine practice vs. scientific evidence

De Caterina R, Liga R, Boden WE. Eur Heart J 2022;43:387–90.

The year in cardiovascular medicine 2021: heart failure and cardiomyopathies

Bauersachs J, de Boer RA, Lindenfeld J, Bozkurt B. Eur Heart J 2022;43:367–76.

The contribution of cardiac fatty acid oxidation to diabetic cardiomyopathy severity

Karwi QG, Sun Q, Lopaschuk GD. Cells 2021;10:3259.

Mesenchymal stem cell therapy in diabetic cardiomyopathy

da Silva JS, Gonçalves RGJ, Vasques JF, et al. Cells 2022;11:240.

Hypertrophic cardiomyopathy: a practical approach to guideline directed management

Ommen SR, Semsarian C. Lancet 2021;398:2102–8.

Cardiomyopathies: an overview

Ciarambino T, Menna G, Sansone G, Giordano M. Int J Mol Sci 2021;22:7722.

The emerging role of epigenetics in therapeutic targeting of cardiomyopathies

Pagiatakis C, Mauro VD. Int J Mol Sci 2021;22:8721.

Pathogenic mechanisms of hypertrophic cardiomyopathy beyond sarcomere dysfunction

Chou C, Chin MT. Int J Mol Sci 2021;22:8933.

Arrhythmogenic potential of myocardial disarray in hypertrophic cardiomyopathy: genetic basis, functional consequences and relation to sudden cardiac death

Finocchiaro G, Sheikh N, Leone O, et al. Europace 2021;23:985–95.

Preventative therapeutic approaches for hypertrophic cardiomyopathy

Solomon T, Filipovska A, Hool L, Viola H. J Physiol 2021;599:3495–512.

The multifaceted view of heart problem in Duchenne muscular dystrophy

Florczyk-Soluch U, Polak K, Dulak J. Cell Mol Life Sci 2021;78:5447–68.

Return to play with hypertrophic cardiomyopathy: are we moving too fast? A critical review

Drezner JA, Malhotra A, Prutkin JM, et al. Br J Sports Med 2021;55:1041–8.

Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

Ren J, Wu NN, Wang S, et al. Physiol Rev 2021;101:1745–807.

Cardiac fibrosis and fibroblasts

Kurose H. Cells 2021;10:1716.

Genetic testing in patients with hypertrophic cardiomyopathy

Bonaventura J, Polakova E, Vejtasova V, Veselka J. Int J Mol Sci 2021;22:10401.

Update on the diagnostic pitfalls of autopsy and post-mortem genetic testing in cardiomyopathies

Grassi S, Campuzano O, Coll M, et al. Int J Mol Sci 2021;22:4124.

Emerging medical treatment for hypertrophic cardiomyopathy

Argirò A, Zampieri M, Berteotti M, et al. J Clin Med 2021;10:951.

Mavacamten, a novel therapeutic strategy for obstructive hypertrophic cardiomyopathy

Zampieri M, Argirò A, Marchi A, et al. Curr Cardiol Rep 2021;23:79.

Catheter Management Of Hypertrophic Cardiomyopathy

Dahal R, Siddiqui T, Adnan G. Catheter Management Of Hypertrophic Cardiomyopathy. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. 2021 May 2.

Differential diagnosis of apical hypertrophic cardiomyopathy and apical displacement of the papillary muscles: a multimodality imaging point of view

Ünlü S, Özden Tok Ö, Avcı Demir F, et al. Echocardiography 2021;38:103–13.

The role of mitral valve in hypertrophic obstructive cardiomyopathy: an updated review

Sakellaropoulos S, Svab S, Mohammed M, et al. Curr Probl Cardiol 2021;46:100641.

Coronary microvascular dysfunction in hypertrophic cardiomyopathy: pathophysiology, assessment, and clinical impact

Aguiar Rosa S, Rocha Lopes L, Fiarresga A, et al. Microcirculation 2021;28:e12656.

Mitral valve in hypertrophic cardiomyopathy: a three-dimensional transesophageal study

Venieri E, Aggeli C, Anastasakis A, et al. Hellenic J Cardiol 2021;62:29–34.

The regulatory roles of p53 in cardiovascular health and disease

Men H, Cai H, Cheng Q, et al. Cell Mol Life Sci 2021;78:2001–18.

Disopyramide

Sundjaja JH, Makaryus AN. Disopyramide. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. 2021 May 28.

Cardiovascular genetics: the role of genetic testing in diagnosis and management of patients with hypertrophic cardiomyopathy

Ahluwalia M, Ho CY. Heart 2021;107:183–9.

Targeting the population for gene therapy with MYBPC3

Carrier L. J Mol Cell Cardiol 2021;150:101–8.

Calcium Channel Blockers

McKeever RG, Hamilton RJ. Calcium Channel Blockers. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. 2020 Jul 10.

Hypertrophic cardiomyopathy in pregnancy

Saberi S. Cardiol Clin 2021;39:143–50.

Epidemiology of the inherited cardiomyopathies

McKenna WJ, Judge DP. Nat Rev Cardiol 2021;18:22–36.

Hypertrophic Cardiomyopathy

Basit H, Brito D, Sharma S. Hypertrophic Cardiomyopathy. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. 2021 Jul 11.

Hypertrophic Cardiomyopathy Overview

Cirino AL, Ho C. Hypertrophic Cardiomyopathy Overview. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mirzaa G, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2021. 2008 [updated 2021].

Efficacy of echocardiography for differential diagnosis of left ventricular hypertrophy: special focus on speckle-tracking longitudinal strain

Tanaka H. J Echocardiogr 2021;19:71–9.

Risk of chronic cardiomyopathy among patients with the acute phase or indeterminate form of Chagas disease: a systematic review and meta-analysis

Chadalawada S, Sillau S, Archuleta S, et al. JAMA Netw Open 2020;3:e2015072.

Contemporary application of cardiovascular magnetic resonance imaging

Han Y, Chen Y, Ferrari VA. Annu Rev Med 2020;71:221–34.

Epsilon waves in biventricular arrythmogenic cardiomyopathy

Lezcano Gort LE, Kounka Z, Roque Rodríguez B. Ann Emerg Med 2020;76:583–5.

Hypertrophic cardiomyopathy: is a 'cure' coming . . . or is it already here?

Maron BJ, Rowin EJ, Maron MS. Am J Med 2020;133:886–8.

Pharmacotherapy for the treatment of obstructive hypertrophic cardiomyopathy

Spoladore R, Fragasso G, Pannone L, et al. Expert Opin Pharmacother 2020;21:233–42.

Prognostic value of myocardial fibrosis on cardiac magnetic resonance imaging in patients with ischemic cardiomyopathy: a systematic review

Chery G, Kamp N, Kosinski AS, et al. Am Heart J 2020;229:52–60.

Arrhythmogenic Cardiomyopathy: A Disease or Merely a Phenotype?

European Cardiology Review 2020;15:e11.

Clinical Features and Outcomes of Patients with Chemotherapy-induced Takotsubo Syndrome

US Cardiology Review 2019;13(2):74–82.

Hypertrophic Cardiomyopathy in Athletes

European Cardiology Review 2017;12(2):80–2

Role of T1 Mapping in Inherited Cardiomyopathies

European Cardiology Review 2016;11(2):96–101

Atrial Fibrillation and Anticoagulation in Hypertrophic Cardiomyopathy

Arrhythmia & Electrophysiology Review 2017;6(2):63–8.

Subclinical Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy

US Cardiology Review 2016;10(2):75–7

Arrhythmogenic Cardiomyopathy: Electrical and Structural Phenotypes

Arrhythmia & Electrophysiology Review 2016;5(2):90–101

ICD Therapy for Primary Prevention in Hypertrophic Cardiomyopathy

Arrhythmia & Electrophysiology Review 2016;5(3):188–96

The Role of Cardiac MRI in the Diagnosis and Risk Stratification of Hypertrophic Cardiomyopathy

Arrhythmia & Electrophysiology Review 2016;5(3):197–202

Risk Stratification in Hypertrophic Cardiomyopathy

European Cardiology Review 2015;10(1):31–6

Alcohol Septal Ablation for the Treatment of Hypertrophic Obstructive Cardiomyopathy

Interventional Cardiology Review 2014;9(2):108-14

Mimics of Hypertrophic Cardiomyopathy - Diagnostic Clues to Aid Early Identification of Phenocopies

Arrhythmia & Electrophysiology Review 2013;2(1):36-40

Troponin in Non-ischaemic Dilated Cardiomyopathy

European Cardiology 2011;7(3):220–4

Diagnosis and Management of Cardiomyopathies - A Focus on Genetics, Cardiac Magnetic Resonance and Clinical Features

European Cardiology 2011;7(3):225–9

Histopathological Changes and Clinical Implications in Patients with Hypertrophic Cardiomyopathy

European Cardiology 2010;6(2):88–90

Left Ventricular Non-compaction Cardiomyopathy

American Heart Hospital Journal 2010;8(2):122–4

Myocardial Perfusion Imaging in Hypertrophic Cardiomyopathy

American Heart Hospital Journal 2010;8(2):103–4

Inherited Channelopathies and Cardiomyopathies - When Is Invasive Risk Stratification Needed?

Asia-Pacific Cardiology 2011;3(1):64-6

Alcohol Septal Ablation for Obstructive Hypertrophic Cardiomyopathy

European Cardiovascular Disease 2007;3(2):88–91

Case Studies

Transcatheter mitral intervention relieves dynamic outflow obstruction and reduces cardiac workload in hypertrophic cardiomyopathy

Kimmelstiel C, Everett KD, Jain P, et al. Circ Heart Fail 2022;15:e009171.

Complete resolution of apical hypertrophy and fibrosis: the role of serial cardiovascular magnetic resonance tissue characterization to differentiate hypertrophic cardiomyopathy from myocarditis

Wilson J, Muthumala A, Khanji MY. Eur Heart J 2022;43:1774.

Multimodality imaging and histopathology in a young man presenting with fulminant lymphocytic myocarditis and cardiogenic shock after mRNA-1273 vaccination

Kadwalwala M, Chadha B, Ortoleva J, Joyce M. BMJ Case Rep 2021;14:e246059.

Mutation of the MYL3 gene in a patient with mid-ventricular obstructive hypertrophic cardiomyopathy

Mavilakandy A, Ahamed H. BMJ Case Rep 2022;15:e244573.

Acute-onset heart failure secondary to biventricular non-compaction cardiomyopathy and atrial septal defect in a woman presenting in the seventh decade

Sharma P, Jobanputra Y, Chait R, Ghumman W. BMJ Case Rep 2022;15:e246385.

Clinically suspected myocarditis temporally related to COVID-19 vaccination in adolescents and young adults: suspected myocarditis after COVID-19 vaccination

Truong DT, Dionne A, Muniz JC, et al. Circulation 2022;145:345–56.

A pacemaker red herring and a hypertrophic cardiomyopathy copycat

Raber I, Palmeri NO, Tahir UA, Zimetbaum PJ. Circulation 2022;145:622–5.

Carditis after COVID-19 vaccination with a messenger RNA vaccine and an inactivated virus vaccine : a case–control study

Lai FTT, Li X, Peng K, et al. Ann Intern Med 2022;175:362–70.

'Heart within a heart': echocardiographic assessment of hypertrophic cardiomyopathy

Weerasekare JM, Geske JB. Eur Heart J 2021;42:4775.

Hydroxychloroquine-induced cardiomyopathy accelerated after gastric banding

Lodge FM, Moody WE, Tosounidou S, et al. Lancet 2021;398:1913.

Rare presentation of Fabry disease as 'burnt-out' hypertrophic cardiomyopathy

Williams S, El-Medany A, Nightingale A, Ismail Y. BMJ Case Rep 2021;14:e243604.

Anderson–Fabry disease: a rare phenocopy of hypertrophic cardiomyopathy

Yang K, Wei MD, Chen XY, Zhao SH. Eur Heart J Cardiovasc Imaging 2021;22:e94.

Myocarditis after covid-19 mRNA vaccination

Verma AK, Lavine KJ, Lin CY. N Engl J Med 2021;385:1332–4.

Myocarditis combined with hypertrophic cardiomyopathy: a case report

Wang JY, Wang YS, Shen BT. Ann Palliat Med 2021; epub ahead of press.

A special case of hypertrophic cardiomyopathy with a differential diagnosis of isolated cardiac amyloidosis or junctophilin type 2 associated cardiomyopathy

De Bruijn S, Galloo X, De Keulenaer G, et al. Acta Clin Belg 2021;76:136–43.

Nonobstructive hypertrophic cardiomyopathy in a patient with mitral prosthesis

Sun D, Schaff HV, Gersh BJ, Borlaug BA. Ann Thorac Surg 2021;111:e429–32.

Management and outcome of hypertrophic obstructive cardiomyopathy in pregnant women: a case report

Assamti M, Bougrine R, Ismaili N, Ouafi NE. Pan Afr Med J 2021;38:140.

Editorials

Commentary: left heart remodeling with septal myectomy: fibrosis is a relative but not absolute concern

Blitzer D, Weiner SD, Nguyen SN, Takayama H. J Thorac Cardiovasc Surg 2022;163:1837–8.

Commentary: paradoxical increase in areas of myocardial fibrosis following septal myectomy

Nguyen A. J Thorac Cardiovasc Surg 2022;163:1835.

Hypertrophic cardiomyopathy risk scoring for sudden cardiac death in paediatrics, adolescents, and adults: stuck on the puzzle of clinical, imaging, and genetic features

Bianco F, Bucciarelli V. Eur J Prev Cardiol 2022;29:675–7.

Septal reduction strategies in hypertrophic cardiomyopathy—the scalpel, catheter, or wire?

Bataiosu DR, Rakowski H. JAMA Cardiol 2022;7:538–9.

Surgical septal myectomy and alcohol ablation: not equivalent in efficacy or survival

Sherrid MV, Massera D, Swistel DG. J Am Coll Cardiol 2022;79:1656–9.

Cardiac myosin inhibitors for obstructive hypertrophic cardiomyopathy: where are we on the hype cycle?

Ommen SR. J Am Coll Cardiol 2022;80:109–10.

Hypertrophic cardiomyopathy: a problem at any age

Rossano JW, Lin KY. J Am Coll Cardiol 2022;79:1998–2000.

Beta-blockers and exercise hemodynamics in hypertrophic cardiomyopathy

Borlaug BA, Omote K. J Am Coll Cardiol 2022;79:1576–8.

Targeting the cause of obstructive hypertrophic cardiomyopathy

Larkin HD. JAMA 2022;327:2067.

Future role of new negative inotropic agents in the era of established surgical myectomy for symptomatic obstructive hypertrophic cardiomyopathy

Maron BJ, Maron MS, Sherrid MV, Rowin EJ. J Am Heart Assoc 2022;11:e024566.

Cardiac myosin inhibitors as a novel treatment option for obstructive hypertrophic cardiomyopathy: addressing the core of the matter

Masri A, Olivotto I. J Am Heart Assoc 2022;11:e024656.

Editorial for "left ventricular outflow tract obstruction in hypertrophic cardiomyopathy: the utility of myocardial strain based on cardiac MR tissue tracking"

Boban M. J Magn Reson Imaging 2021;53:552–3.

Ablation of atrial fibrillation in hypertrophic cardiomyopathy: Semper Discere (Always Learning)

Estes NAM 3rd, Wong TC. J Am Heart Assoc 2021;10:e019876.

Radcliffe Content

Rare Presentation of Cardiac Sarcoidosis With Recurrent Large Pericardial Effusion and Stress-induced Cardiomyopathy

Journal of Asian Pacific Society of Cardiology 2022;1:e23.

Imaging in Women with Heart Failure: Sex-specific Characteristics and Current Challenges

Cardiac Failure Review 2022;8:e29.

Fundamentals of Heart Recovery Versus Remission

Interventional Cardiology Review 2022;17(Suppl 1):29–30.

Effect of Ventricular Unloading on Heart Recovery

Interventional Cardiology Review 2022;17(Suppl 1):20.

Chest Pain in the Cancer Patient

European Cardiology Review 2022;17:e15.

Advocacy and Legislation for Regionalization Practices in the Treatment of Cardiogenic Shock: The Time Is Now

US Cardiology Review 2022;16:e06.

Extracorporeal Membrane Oxygenation as a Treatment for Branch Pulmonary Artery Rupture Following Right Heart Catheterisation

Cardiac Failure Review 2022;8:e03.

Carbohydrate Antigen 125: A Biomarker at the Crossroads of Congestion and Inflammation in Heart Failure

Cardiac Failure Review 2021;7:e19.

Extracorporeal Life Support for Cardiac Arrest and Cardiogenic Shock

US Cardiology Review 2021;15:e23.

Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmia & Electrophysiology Review 2021;10(1):26–32.

Foreword

Interventional Cardiology Review 2021;16(Suppl 2):4.

Novel Aspects of Classification, Prognosis and Therapy in Takotsubo Syndrome

European Cardiology Review 2019;14(3):191–6

Diagnosis and Therapy of Cardiac Sarcoidosis: A Clinical Perspective

US Cardiology Review 2019;13(1):41–5

Diabetic Cardiomyopathy: Five Major Questions with Simple Answers

US Cardiology Review 2019;13(1):46–8

Chagas Disease and Heart Failure: An Expanding Issue Worldwide

European Cardiology Review 2019;14(2):82–8

Hidden in Heart Failure

European Cardiology Review 2019;14(2):89–96

Preventive Ventricular Tachycardia Ablation in Patients with Ischaemic Cardiomyopathy: Meta-analysis of Randomised Trials

Arrhythmia & Electrophysiology Review 2019;8(3):173–9.

Amyloid Heart Disease

US Cardiology Review 2018;12(2):113–8.

Relationship Between VEGF-C Levels and All-cause Mortality in Patients with Chronic Heart Failure

European Cardiology Review 2018;13(2):129.

A PRMT5 Selective Inhibitor EPZ015666 Suppressed TAC-induced Left Ventricular Dysfunction

European Cardiology Review 2018;13(2):130.

Association of pathogenic DNA variants predisposing to cardiomyopathy with cardiovascular disease outcomes and all-cause mortality

Patel AP, Dron JS, Wang M, et al. JAMA Cardiol 2022;7:723–32.

Rare and common genetic variation underlying the risk of hypertrophic cardiomyopathy in a national biobank

Biddinger KJ, Jurgens SJ, Maamari D, et al. JAMA Cardiol 2022;7:715–22.

High-throughput precision phenotyping of left ventricular hypertrophy with cardiovascular deep learning

Duffy G, Cheng PP, Yuan N, et al. JAMA Cardiol 2022;7:386–95.

Percutaneous intramyocardial septal radiofrequency ablation in patients with drug-refractory hypertrophic obstructive cardiomyopathy

Zhou M, Ta S, Hahn RT, et al. JAMA Cardiol 2022;7:529–38.

Muscle LIM protein force-sensing mediates sarcomeric biomechanical signaling in human familial hypertrophic cardiomyopathy

Riaz M, Park J, Sewanan LR, et al. Circulation 2022;145:1238–53.

Association of septal myectomy with quality of life in patients with left ventricular outflow tract obstruction from hypertrophic cardiomyopathy

Desai MY, Tower-Rader A, Szpakowski N, et al. JAMA Netw Open 2022;5:e227293.

Assessment of disease status and treatment response with artificial intelligence−enhanced electrocardiography in obstructive hypertrophic cardiomyopathy

Tison GH, Siontis KC, Abreau S, et al. J Am Coll Cardiol 2022;79:1032–4.

Survival following alcohol septal ablation or septal myectomy for patients with obstructive hypertrophic cardiomyopathy

Cui H, Schaff HV, Wang S, et al. J Am Coll Cardiol 2022;79:1647–55.

Clinical features and natural history of preadolescent nonsyndromic hypertrophic cardiomyopathy

Norrish G, Cleary A, Field E, et al. J Am Coll Cardiol 2022;79:1986–97.

Effects of metoprolol on exercise hemodynamics in patients with obstructive hypertrophic cardiomyopathy

Dybro AM, Rasmussen TB, Nielsen RR, et al. J Am Coll Cardiol 2022;79:1565–75.

Impact of autophagy on prognosis of patients with dilated cardiomyopathy

Kanamori H, Yoshida A, Naruse G, et al. J Am Coll Cardiol 2022;79:789–801.

Long-term cardiovascular outcomes of COVID-19

Xie Y, Xu E, Bowe B, Al-Aly Z. Nat Med 2022;28:583–90.

Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC EORP PPCM Registry

Jackson AM, Petrie MC, Frogoudaki A, et al. Eur J Heart Fail 2021;23:2058–69.

Phenotypic expression, natural history, and risk stratification of cardiomyopathy caused by filamin C truncating variants

Gigli M, Stolfo D, Graw SL, et al. Circulation 2021;144:1600–11.

Altered cardiac energetics and mitochondrial dysfunction in hypertrophic cardiomyopathy

Ranjbarvaziri S, Kooiker KB, Ellenberger M, et al. Circulation 2021;144:1714–31.

Association between sarcomeric variants in hypertrophic cardiomyopathy and myocardial oxygenation: insights from a novel oxygen-sensitive cardiovascular magnetic resonance approach

Raman B, Tunnicliffe EM, Chan K, et al. Circulation 2021;144:1656–8.

Effect of mavacamten on echocardiographic features in symptomatic patients with obstructive hypertrophic cardiomyopathy

Hegde SM, Lester SJ, Solomon SD, et al. J Am Coll Cardiol 2021;78:2518–32.

Randomized trial of metoprolol in patients with obstructive hypertrophic cardiomyopathy

Dybro AM, Rasmussen TB, Nielsen RR, et al. J Am Coll Cardiol 2021;78:2505–17.

Acute myocarditis following COVID-19 mRNA vaccination in adults aged 18 years or older

Simone A, Herald J, Chen A, et al. JAMA Intern Med 2021;181:1668–70.

Role of plakophilin-2 expression on exercise-related progression of arrhythmogenic right ventricular cardiomyopathy: a translational study

Cerrone M, Marrón-Liñares GM, van Opbergen CJM, et al. Eur Heart J 2022;43:1251–64.

SARS-CoV-2 vaccination and myocarditis or myopericarditis: population based cohort study

Husby A, Hansen JV, Fosbøl E, et al. BMJ 2021;375:e068665.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021

Oster ME, Shay DK, Su JR, et al. JAMA 2022;327:331–40.

Prevalence and cumulative risk of familial idiopathic dilated cardiomyopathy

Huggins GS, Kinnamon DD, Haas GJ, et al. JAMA 2022;327:454–63.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection

Patone M, Mei XW, Handunnetthi L, et al. Nat Med 2022;28:410–22.

Myocarditis after BNT162b2 mRNA vaccine against covid-19 in Israel

Mevorach D, Anis E, Cedar N, et al. N Engl J Med 2021;385:2140–9.

Myocarditis after covid-19 vaccination in a large health care organization

Witberg G, Barda N, Hoss S, et al. N Engl J Med 2021;385:2132–9.

Long-term risk of sudden cardiac death in hypertrophic cardiomyopathy: a cardiac magnetic resonance outcome study

Greulich S, Seitz A, Herter D, et al. Eur Heart J Cardiovasc Imaging 2021;22:732–41.

Catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy: a European observational multicentre study

Creta A, Elliott P, Earley MJ, et al. Europace 2021;23:1409–17.

Echocardiographic characteristics of severe left ventricular outflow tract obstruction in hypertrophic cardiomyopathy

Jain CC, Miranda WR, Geske JB, et al. J Am Soc Echocardiogr 2021;34:798–801.

Left atrial strain and function in pediatric hypertrophic cardiomyopathy

Jhaveri S, Komarlu R, Worley S, et al. J Am Soc Echocardiogr 2021;34:996–1006.

Sleep disordered breathing and mortality in patients with hypertrophic obstructive cardiomyopathy undergoing septal myectomy

Cui H, Schaff HV, Somers VK, et al. Mayo Clin Proc 2021;96:2323–31.

Alcohol septal ablation for hypertrophic cardiomyopathy through an anomalous septal perforator off the right cusp

Mahowald MK, Corban MT, Eleid MF, Nishimura RA. JACC Cardiovasc Interv 2021;14:e129–30.

Veselka J, Faber L, Liebregts M, et al. JACC Cardiovasc Interv 2021;14:1390–2.

Computational prediction of protein subdomain stability in MYBPC3 enables clinical risk stratification in hypertrophic cardiomyopathy and enhances variant interpretation

Thompson AD, Helms AS, Kannan A, et al. Genet Med 2021;23:1281–7.

Association of physical activity with all-cause and cardiovascular mortality in 7666 adults with hypertrophic cardiomyopathy (HCM): more physical activity is better

Kwon S, Lee HJ, Han KD, et al. Br J Sports Med 2021;55:1034–40.

Alpha-protein kinase 3 (ALPK3) truncating variants are a cause of autosomal dominant hypertrophic cardiomyopathy

Lopes LR, Garcia-Hernández S, Lorenzini M, et al. Eur Heart J 2021;42:3063–73.

Worldwide differences in primary prevention implantable cardioverter defibrillator utilization and outcomes in hypertrophic cardiomyopathy

Nauffal V, Marstrand P, Han L, et al. Eur Heart J 2021;42:3932–44.

Myocarditis and pericarditis after vaccination for COVID-19

Diaz GA, Parsons GT, Gering SK, et al. JAMA 2021;326:1210–2.

Surveillance for adverse events after COVID-19 mRNA vaccination

Klein NP, Lewis N, Goddard K, et al. JAMA 2021;326:1390–9.

Patterns of replacement fibrosis in hypertrophic cardiomyopathy

Liu J, Zhao S, Yu S, et al. Radiology 2021; epub ahead of press.

Safety of the BNT162b2 mRNA covid-19 vaccine in a nationwide setting

Barda N, Dagan N, Ben-Shlomo Y, et al. N Engl J Med 2021;385:1078–90.

MiRNAs as biomarkers in hypertrophic cardiomyopathy: current state of the art

Angelopoulos A, Oikonomou E, Vogiatzi G, et al. Curr Med Chem 2021; epub ahead of press.

Alcohol dose in septal ablation for hypertrophic obstructive cardiomyopathy

Veselka J, Faber L, Liebregts M, et al. Int J Cardiol 2021;333:127–32.

Ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy: treatment strategy, characteristics of consecutive atrial tachycardia and long‐term outcome

Dinshaw L, Münkler P, Schäffer B, et al. J Am Heart Assoc 2021;10:e017451.

Does ablation of atrial fibrillation at the time of septal myectomy improve survival of patients with obstructive hypertrophic cardiomyopathy?

Cui H, Schaff HV, Dearani JA, et al. J Thorac Cardiovasc Surg 2021;161:997–1006.e3.

Mutations in myosin S2 alter cardiac myosin-binding protein-C interaction in hypertrophic cardiomyopathy in a phosphorylation-dependent manner

Singh RR, McNamara JW, Sadayappan S. J Biol Chem 2021;297:100836.

Prevalence and clinical correlates of aortic dilation in hypertrophic cardiomyopathy

Geske JB, Nordhues BD, Orme NM, et al. J Am Soc Echocardiogr 2021;34:279–85.

Increased heart rate with sleep disordered breathing in hypertrophic cardiomyopathy

Konecny T, Khoo M, Covassin N, et al. Int J Cardiol 2021;323:155–60.

Matrix metalloproteinases increase because of hypoperfusion in obstructive hypertrophic cardiomyopathy

Bi X, Yang C, Song Y, et al. Ann Thorac Surg 2021;111:915–22.

A systematic review of microRNAs in patients with hypertrophic cardiomyopathy

Scolari FL, Faganello LS, Garbin HI, et al. Int J Cardiol 2021;327:146–54.

Dynamic thiol/disulphide homeostasis in patients with hypertrophic cardiomyopathy

Sari M, Erkorkmaz U, Yazar H, et al. Herz 2021;46:164–71.

Prognostic impact of atrial fibrillation in hypertrophic cardiomyopathy: a systematic review

Alphonse P, Virk S, Collins J, et al. Clin Res Cardiol 2021;110:544–54.

Anticoagulation for stroke prevention in patients with hypertrophic cardiomyopathy and atrial fibrillation: a review

Nasser MF, Gandhi S, Siegel RJ, Rader F. Heart Rhythm 2021;18:297–302.

Transapical septal myectomy for hypertrophic cardiomyopathy with midventricular obstruction

Sun D, Schaff HV, Nishimura RA, et al. Ann Thorac Surg 2021;111:836–44.

Arrhythmias and conduction disturbances in autoimmune rheumatic disorders

Plastiras SC, Moutsopoulos HM. Arrhythm Electrophysiol Rev 2021;10:17–25.

Coronavirus disease 2019: cardiac complications and considerations for returning to sports participation

Augustine DX, Keteepe-Arachi T, Malhotra A. Eur Cardiol 2021;16:e03.

Direct oral anticoagulants in Asian patients with atrial fibrillation: consensus recommendations by the Asian Pacific Society of Cardiology on strategies for thrombotic and bleeding risk management

Chong DTT, Andreotti F, Verhamme P, et al. Eur Cardiol 2021;16:e23.

Electrocardiographic criteria for differentiating left from right idiopathic outflow tract ventricular arrhythmias

Mariani MV, Piro A, Della Rocca DG, et al. Arrhythm Electrophysiol Rev 2021;10:10–6.

Bridging the gap in a rare cause of angina

Khadke S, Vidovic J, Patel V. Eur Cardiol 2021;16:e05.

Mavacamten favorably impacts cardiac structure in obstructive hypertrophic cardiomyopathy: EXPLORER-HCM cardiac magnetic resonance substudy analysis

Saberi S, Cardim N, Yamani M, et al. Circulation 2021;143:606–8.

Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure

Teerlink JR, Diaz R, Felker GM, et al. N Engl J Med 2021;384:105–16.

Mavacamten: treatment aspirations in hypertrophic cardiomyopathy

Papadakis M, Basu J, Sharma S. Lancet 2020;396:736–7.

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial

Olivotto I, Oreziak A, Barriales-Villa R, et al. Lancet 2020;396:759–69.

Outcomes in patients with hypertrophic cardiomyopathy and left ventricular systolic dysfunction

Rowin EJ, Maron BJ, Carrick RT, et al. J Am Coll Cardiol 2020;75:3033–43.

Penetrance of hypertrophic cardiomyopathy in sarcomere protein mutation carriers

Lorenzini M, Norrish G, Field E, et al. J Am Coll Cardiol 2020;76:550–9.

Evaluation of mavacamten in symptomatic patients with nonobstructive hypertrophic cardiomyopathy

Ho CY, Mealiffe ME, Bach RG, et al. J Am Coll Cardiol 2020;75:2649–60.

Distinct subgroups in hypertrophic cardiomyopathy in the NHLBI HCM Registry

Neubauer S, Kolm P, Ho CY, et al. J Am Coll Cardiol 2019;74:2333–45.

Detection of hypertrophic cardiomyopathy using a convolutional neural network-enabled electrocardiogram

Ko WY, Siontis KC, Attia ZI, et al. J Am Coll Cardiol 2020;75:722–33.

Association of hypertrophic obstructive cardiomyopathy with outcomes following transcatheter aortic valve replacement

Bandyopadhyay D, Chakraborty S, Amgai B, et al. JAMA Netw Open 2020;3:e1921669.

Incidence of stress cardiomyopathy during the coronavirus disease 2019 pandemic

Jabri A, Kalra A, Kumar A, et al. JAMA Netw Open 2020;3:e2014780.

Efficacy and safety of tafamidis doses in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR‐ACT) and long‐term extension study

Damy T, Garcia-Pavia P, Hanna M, et al. Eur J Heart Fail 2020; epub ahead of press.

Biventricular pacemaker therapy improves exercise capacity in patients with non‐obstructive hypertrophic cardiomyopathy via augmented diastolic filling on exercise

Ahmed I, Loudon BL, Abozguia K, et al. Eur J Heart Fail 2020;22:1263–72.

Advanced imaging insights in apical hypertrophic cardiomyopathy

Hughes RK, Knott KD, Malcolmson J, et al. JACC Cardiovasc Imaging 2020;13:624–30.

Clinical outcomes in adult athletes with hypertrophic cardiomyopathy: a 7-year follow-up study

Pelliccia A, Caselli S, Pelliccia M, et al. Br J Sports Med 2020;54:1008–12.

Development of a novel risk prediction model for sudden cardiac death in childhood hypertrophic cardiomyopathy (HCM Risk-Kids)

Norrish G, Ding T, Field E, et al. JAMA Cardiol 2019;4:918–27.

Association of race with disease expression and clinical outcomes among patients with hypertrophic cardiomyopathy

Eberly LA, Day SM, Ashley EA, et al. JAMA Cardiol 2020;5:83–91.

Mortality among referral patients with hypertrophic cardiomyopathy vs the general European population

Lorenzini M, Anastasiou Z, O’Mahony C, et al. JAMA Cardiol 2020;5:73–80.

Association of obesity with adverse long-term outcomes in hypertrophic cardiomyopathy

Fumagalli C, Maurizi N, Day SM, et al. JAMA Cardiol 2020;5:65–72.

Undetermined stroke genesis and hidden cardiomyopathies determined by cardiac magnetic resonance

Fonseca AC, Marto JP, Pimenta D, et al. Neurology 2020;94:e107–13.

Study design and rationale of EXPLORER-HCM: evaluation of mavacamten in adults with symptomatic obstructive hypertrophic cardiomyopathy

Ho CY, Olivotto I, Jacoby D, et al. Circ Heart Fail 2020;13.

Risk stratification in cardiomyopathy

Sinagra G, Carriere C, Clemenza F, et al. Eur J Prev Cardiol 2020;27:52–8.

Access and outcomes among hypertrophic cardiomyopathy patients in a large integrated health system

Thomas A, Papoutsidakis N, Spatz E, et al. J Am Heart Assoc 2020;9.

Myocardial contraction fraction predicts mortality for patients with hypertrophic cardiomyopathy

Liao H, Wang Z, Zhao L, et al. Sci Rep 2020;10:17026.

Left ventricular global function index by magnetic resonance imaging — a novel marker for differentiating cardiac amyloidosis from hypertrophic cardiomyopathy

Huang S, Xu HY, Diao KY, et al. Sci Rep 2020;10:4707.

Implantable cardioverter defibrillators in patients with electrical heart disease and hypertrophic cardiomyopathy: data from the German device registry

Frommeyer G, Reinke F, Andresen D, et al. Clin Res Cardiol 2020;109:508–12.

Hypertrophic cardiomyopathy - a heterogeneous and lifelong disease in the real world

Kitaoka H, Kubo T, Doi YL. Circ J 2020;84:1218–26.

Comparison of expected and observed outcomes for septal myectomy in hypertrophic obstructive cardiomyopathy

Geske JB, Driver CN, Yogeswaran V, et al. Am Heart J 2020;221:159–64.

Sex-specific cardiac phenotype and clinical outcomes in patients with hypertrophic cardiomyopathy

Lu DY, Ventoulis I, Liu H, et al. Am Heart J 2020;219:58–69.

Addis DR, Townsley MM. J Cardiothorac Vasc Anesth 2022;36:2143–53.

Saito C, Minami Y, Haruki S, et al. J Am Soc Echocardiogr 2022;35:469–76.

Recommendations for multimodality cardiovascular imaging of patients with hypertrophic cardiomyopathy

Nagueh SF, Phelan D, Abraham T, et al. J Am Soc Echocardiogr 2022;35:533–69.

Zegkos T, Tziomalos G, Parcharidou D, et al. Hellenic J Cardiol 2022;63:15–21.

Process of care and a practical toolkit for evaluating and managing arrhythmic risk in the cardiogenetic pregnant patient

Cheung CC, Roston TM, Davies B, et al. Can J Cardiol 2021;37:2001–13.

Comparing clinical performance of current implantable cardioverter-defibrillator implantation recommendations in arrhythmogenic right ventricular cardiomyopathy

Bosman LP, Nielsen Gerlach CL, Cadrin-Tourigny J, et al. Europace 2022;24:296–305.

2021: The American Association for Thoracic Surgery Expert Consensus Document: coronary artery bypass grafting in patients with ischemic cardiomyopathy and heart failure

Bakaeen FG, Gaudino M, Whitman G, et al. J Thorac Cardiovasc Surg 2021;162:829–50.e1.

The wait is over: the 2020 American Heart Association/American College of Cardiology (AHA/ACC) hypertrophic cardiomyopathy guidelines have arrived

Semsarian C, Davis L. Heart Lung Circ 2021;30:465–8.

Recommendations of the current guidelines for implantable cardioverter-defibrillator implantation in patients with hypertrophic cardiomyopathy: debate still exists

Aminorroaya A, Vasheghani-Farahani A, Masoudkabir F, Roayaei P. J Interv Card Electrophysiol 2021;60:1–7.

Guidelines on the verge of a more evidence-based era for hypertrophic cardiomyopathy

Ho CY. Circulation 2021;143:295–7.

Writing Committee Members, Ommen SR, Mital S, et al. J Thorac Cardiovasc Surg 2021;162:e23–106.

Writing Committee Members, Ommen SR, Mital S, et al. Circulation 2020;142:e533–57.

Clarification of the Australian heart failure guideline recommendation for primary prevention defibrillator implantation in non‐ischaemic cardiomyopathy

Kistler PM, Atherton JJ, Jennings G. Med J Aust 2020;212:509–510.e1.

Genetic testing for inherited cardiovascular diseases: a scientific statement from the American Heart Association

Musunuru K, Hershberger RE, Day SM, et al. Circ Genom Precis Med 2020;13:e000067.

Targeting the sarcomere in inherited cardiomyopathies

Lehman SJ, Crocini C, Leinwand LA. Nat Rev Cardiol 2022;19:353–63.

Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus

Raman B, Bluemke DA, Lüscher TF, Neubauer S. Eur Heart J 2022;43:1157–72.

Hypertrophic cardiomyopathy: new concepts and therapies

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Foreword

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Novel Aspects of Classification, Prognosis and Therapy in Takotsubo Syndrome

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Diagnosis and Therapy of Cardiac Sarcoidosis: A Clinical Perspective

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Diabetic Cardiomyopathy: Five Major Questions with Simple Answers

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Chagas Disease and Heart Failure: An Expanding Issue Worldwide

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