Diabetes
CV Outcomes in Diabetes
Risk reduction with antihyperglycaemic therapies
Cardiovascular (CV) disease remains the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D).
The opportunity for CV disease prevention in patients with T2D has recently expanded with antihyperglycaemic agents demonstrating significant reductions in the risk of major adverse cardiovascular events (MACE). Although the exact mechanisms of CV benefit remain uncertain, they appear to be unrelated to the direct glucose-lowering effects. These agents have triggered a shift beyond glucose control, to a broader strategy of comprehensive CV risk reduction.
CV specialists are well-positioned to play a key role in managing patients with T2D, including screening, aggressively treating CV risk factors, and incorporating the use of antihyperglycaemic agents into routine practice.
In this section
The Radcliffe diabetes and CVD risk program is supported by an educational grant from Novo Nordisk.
Section advisor
Professor Mikhail N Kosiborod
Saint Luke's America Heart Institute, Kansas City, MO, US
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Clinical publications
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Clinical trials
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Congress Updates
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Guidelines
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American Diabetes Association. Diabetes Care 2021;44(Suppl 1):S125–50.
American Diabetes Association. Diabetes Care 2021;44(Suppl 1):S111–24.
London: NICE; 2021.
Ongoing trials
Lo R, Kalantar-Zadeh K, Rhee C. ACC Expert Analysis 22 April 2020.
Rhee JJ, Jardine MJ, Chertow GM, Mahaffey KW. Diabetes Obes Metab 2020;22(Suppl 1):46–54.
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Gerstein HC, Branch K, Heenan L, et al. Diabetes Obes Metab 2021;23:318–23.
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Review articles
Cardiac Failure Review 2019;5(3):169–72.
European Cardiology Review 2014;9(1):37–42
Cardiac Failure Review 2015;1(1):8–10
Cardiac Failure Review 2017;3(1):52–5.
Cardiac Failure Review 2017;3(2):83–5.
US Cardiology Review 2018;12(1):17–21.
European Cardiology Review 2018;13(1):42–5.
European Cardiology Review 2019;14(1):23-32
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