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Direct oral anticoagulants (DOACs) are increasingly used for prevention and treatment of venous thromboembolism and for prevention of stroke in patients with non-valvular atrial fibrillation.

Anticoagulant reversal should only be considered with life-threatening bleeds, with bleeds that fail to respond to usual measures, and in patients requiring urgent surgery.

Idarucizumab is licensed for dabigatran reversal. The Factor Xa inhibitor andexanet alfa has recently been licensed in the US for reversal of rivaroxaban, apixaban and edoxaban.

Related Articles

Articles

Complications in Anticoagulated Patients with AF

George D Katritsis, Demosthenes G Katritsis,

Citation: Arrhythmia & Electrophysiology Review 2017;6(4):167–78.

Oral Anticoagulants in Atrial Fibrillation

Antoni Martínez-Rubio, Mario DiazNuila-Alcazar, Anna Soria Cadena,

Published:

Citation: European Cardiology Review 2016;11(2):118–22

Cardiovascular Pharmacotherapies Focus: Are low doses of direct-acting…

Antoni Martínez-Rubio, Gheorghe-Andrei Dan,

Citation: European Cardiology Review 2016;11(2):115–7

NOACs: Monitoring their Anticoagulant Effects and Use of Antidotes

Nur A Rahmat, Gregory YH Lip,

Citation: Arrhythmia & Electrophysiology Review 2015;4(1):90–5