Can Renal Denervation Benefit Patients with Hypertension?
Hypertension remains a major burden and presents acute challenges in patient care. Sympathetic renal denervation (RDN) emerged as a therapeutic option for patients with resistant hypertension, until Symplicity HTN-3. However, more recently three sham-controlled trials have shed new light on RDN. In this Independent Medical Education webinar, four leading authorities discuss the scientific basis for RDN, the implications of data from SPYRAL OFF, RADIANCE SOLO and SPYRAL ON, its durability, safety and the considerations in patient selection, and look at what lies ahead.
Andrew SP Sharp
This webinar is supported by
Key Learning Objectives
- Hypertension – the burden and current unsolved challenges in patient care
- Sympathetic modulation and the scientific basis for renal denervation
- Early data on the use of catheter-based renal denervation
- Symplicity HTN-3. Where and why did it all go wrong?
- The comeback! What do the three sham-controlled trials recently published tell us about the state of play in RDN?
- So RDN works. What do we need to know now?
- Outcomes and future need
- Interventional cardiologist
- Hypertension specialists
- Interventional Fellows
- Registrars with an interest in interventional cardiology
Andrew SP Sharp
Prof Andrew Sharp is a Consultant Cardiologist at the University Hospital of Wales, Cardiff, UK. Andrew qualified from Edinburgh Medical School in 1998. He was appointed as a Consultant Cardiologist at the Royal Devon and Exeter Hospital in 2011 and Honorary Associate Professor by the University of Exeter in 2018 before moving to the University Hospital of Wales in Cardiff in the summer of 2019.
Andrew conducted his early training at the Royal Infirmary of Edinburgh, before moving to London for his senior clinical training, completing the prestigious Milan-Imperial Interventional Cardiology Fellowship programme. Dr Sharp was awarded an MD postgraduate research degree from the University of Edinburgh for his work on the hypertensive heart and his current research interests include device-based treatments for hypertension, pulmonary embolism, intracoronary imaging and coronary physiology.
Andrew's specialist interests include the pharmacological and interventional treatment of resistant hypertension (including renal denervation); intra-coronary physiology to assess the causes of chest pain; complex angioplasty and stenting of coronary artery disease and CT coronary angiography.
Dr Andrew Sharp is Deputy Editor (Development) of Interventional Cardiology: Reviews, Research, Resources (ICR3)
Dr Indranil Dasgupta is a Consultant Nephrologist at Heart of England NHS Foundation Trust, and is an Honorary Senior Lecturer at the University of Birmingham, UK. His research interests include treatment resistant hypertension. Dr Dasgupta is Clinical Research Lead Division 2 for Renal, Stroke, CVD, Diabetes and Metabolic Diseases for the West Midlands in NIHR Clinical Research Network, Honorary Secretary of the Renal Association UK, and a member of the research working party for the British and Irish Hypertension Society. Dr Dasgupta also serves as an expert adviser for the National Institute for Health and Care Excellence.
Prof Felix Mahfoud is an Associate Professor and senior physician of Internal Medicine and Cardiology at Saarland University Hospital, and Affiliate/Visiting Professor Harvard-MIT Biomedical Engineering, Institute of Medical Engineering and Science, Cambridge, US. Prof Mahfoud completed training in Cardiology and Interventional Cardiology at the Department for Internal Medicine III, Saarland University Hospital, Germany in 2014. Since 2017, he has served as Vice Chairman of the ‘Working Group on Interventional Hypertension Treatment’ for the European Society of Hypertension, and as a Committee Member of the 2018 Hypertension Guidelines.
Dr Atul Pathak is a Pharmacologist and Cardiologist. He is leading a clinical research team focusing on cardiovascular pathophysiology and clinical pharmacology and is affiliated to INSERM (National Institute of Medical Research).
Dr Pathak has been awarded by the ESC (Young Investigator Award), by the British Pharmacological Society and the French Society of Cardiology. He is also member of the French Association of Pharmacologists, the French Society of Hypertension and Cardiology, the American Society for Heart Failure. He is elected President of the Cardiovascular Pharmacology Working Group of the French Society of Cardiology. He has both academic and institutional commitments, among them participation at advisory board at AFSSAPS (French FDA) and HAS for the review of clinical trials protocol, assessment of benefit /risk ratio of drugs (marketed or under development) and medico-economic issues (regarding lipid or blood pressure lowering drugs).