Where Do Potent P2Y12 Inhibitors Fit Into Current Practice? - Balancing Risk Post-PCI

Published: 13 October 2022

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This broadcast series 'Where Do Potent P2Y12 Inhibitors Fit Into Current Practice?' will reappraise potent P2Y12 inhibitors, as evidence accumulates to support their broader use. At this juncture, there is still some uncertainty around patient selection, initiation and long-term management.


The third broadcast in this series, focused on Balancing Risk Post-PCI. In this on-demand version of the live broadcast, Radcliffe Medical Education brings together a global faculty of experts in the field to look at current guidance, the landmark data, gaps in evidence and seeks to provide practical guidance.


Prof Roxana Mehran (Mount Sinai Hospital, New York, US) chairs the proceedings, and is joined by Prof Dominick Angiolillo (University of Florida College of Medicine-Jacksonville, US), Prof Marco Valgimigli (Instituto Cardiocentro Ticino, Lugano, CH) and Prof Pascal Vranckx (University of Hasselt, BE) for a series of insightful presentations and discussions.


You can also catch up on other broadcasts in this series:


This broadcast series is supported by an unrestricted educational grant from AstraZeneca.

Key Learning Objectives

Following the completion of this programme, physicians will be in a position to:

  • Apply the use of validated bleeding risk tools across a wide range of patients
  • Use guidelines and clinical judgement to select antiplatelet therapy regimens in patients at elevated bleeding risk
  • Recall the clinical significance of trial data assessing truncated periods of DAPT
  • Prescribe confidently in patients judged to be at elevated bleeding risk
  • Recall the safety profiles of different P2Y12 inhibitors

Target Audience

  • General Cardiologists
  • Interventional Cardiologists
  • Nurses and any other allied HCPs

More from this programme

Part 1

Clinical Vignette and Panel Discussion

Prof Marco Valgimigli opens this broadcast on balancing bleeding and ischaemic risk post percutaneous coronary intervention, by presenting a high-risk case.

Part 2

Assessing Bleeding Risk Post-PCI

Prof Roxana Mehran discusses optimal strategies for calculating and weighing-up bleeding and ischaemic risk post-PCI, then applies this to our case study which was presented in part one.

Part 3

Optimum Duration of DAPT: Overview of Current Data

Prof Dominick Angiolillo reviews current guidance and evolving clinical data to highlight different antithrombotic strategies to reduce bleeding risk, including shortening dual anti-platelet and single anti-platelet approaches.

Part 4

Bleeding Risk Mitigation - Safety in Clinical Practice and Panel Discussion

Prof Pascal Vranckx explores patient-tailored anti-thrombotic options for subgroups within high bleeding risk and high ischaemic risk patients, tying this in with a forthcoming network meta-analysis and European consensus statement. The panel then bring the discussion back to the case presented at the start, and have an interactive discussion, answering questions from the audience.

Faculty Biographies

Marco Valgimigli

Marco Valgimigli

Deputy Chief of Cardiology

Prof Marco Valgimigli is an Interventional Cardiologist and Deputy Chief of Cardiology at the Cardiocentro Ticino Institute in Lugano, Switzerland.

He obtained his medical degree from the University of Bologna, and completed his training in internal medicine at the same university. He received a degree in cardiological sciences at the University of Ferrara and a PhD in interventional cardiology at Erasmus Medical Center in Rotterdam.

Prof Valgimigli’s areas of research are wide ranging and include high-risk percutaneous interventions (PCI); invasive treatment of myocardial ischaemia (MI); reparative medicine with adult stem cells during MI and heart failure; antithrombotic therapy during and after PCI; and prognostic stratification during acute coronary syndromes and MI.

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Roxana Mehran

Roxana Mehran

Professor of Medicine, Cardiology and Professor of Population Health Science and Policy

Roxana Mehran is Professor of Medicine, Cardiology and Professor of Population Health Science and Policy at the Icahn School of Medicine at Mount Sinai in New York. She is also Director of Interventional Cardiovascular Research and Clinical Trials at The Zena and Michael A Weiner Cardiovascular Institute at Mount Sinai Hospital where, over the past 5 years, she has led the development of a globally respected data and clinical coordination centre to support large, multicentre, multinational clinical trials designed to help improve outcomes and quality of life for patients undergoing interventional cardiovascular procedures. In recent years, her work has had a special emphasis on gaining a deeper understanding of anticoagulation and antiplatelet regimens post angioplasty and transcatheter valve replacement; and collection and interpretation of sex-specific data in cardiovascular clinical trials.

Roxana serves on editorial board of multiple peer reviewed journals, including …

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Dominick J Angiolillo

Dominick J Angiolillo

Professor & Chief

Dr Dominick Angiolillo graduated from the Catholic University of the Sacred Heart Medical School in Rome, Italy and pursued training in interventional cardiology at the Complutense University of Madrid in Spain and received his Ph.D. in cellular and molecular cardiology. Dr Angiolillo is board-certified in internal medicine, cardiovascular disease and interventional cardiology.

In 2004, Dr Angiolillo joined the University of Florida College of Medicine in Jacksonville, where he is a professor of medicine, director of cardiovascular research and director of the interventional cardiology fellowship program. 

Dr Angiolillo has made major scientific contributions to many medical and cardiovascular journals, as well as cardiovascular medicine textbooks. He has authored more than 400 peer-reviewed articles, with nearly 30,000 citations and an H-index of 86. He has authored more than 30 book chapters and is the editor of his…

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Pascal Vranckx

Pascal Vranckx

Clinical Consultant in Interventional Cardiology and Medical Director of Cardiac Critical Care Services

Prof Pascal Vranckx is a Clinical Consultant in Interventional Cardiology and Medical Director of Cardiac Critical Care Services at the Hartcentrum Hasselt in Belgium, and Professor of Medicine at the University of Hasselt, Belgium.

Prof Vranckx is also board member of the European Cardiovascular Research Institute, in Rotterdam, The Netherlands. 

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