Novel Oral Anticoagulants at 10: An Assessment of their Safety and Contemporary Use in Atrial Fibrillation

Published: 04 March 2021

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In this virtual roundtable, our expert panel reflect on the clinical trials and real world data supporting the use of NOACs in atrial fibrillation – almost ten years since they entered the clinic.

Moderated by Prof John Eikelboom, the panel offer their analyses via a series of presentations and discussions covering a range of topics, with a special focus on their use in Japan.

This activity has been supported via an educational grant from Boehringer Ingelheim

Learning Objectives

  • Identify which individuals with atrial fibrillation should be initiated on NOAC therapy without delay
  • Interpret safety and cardiovascular data from RCTs in the context of real-world experience
  • Select appropriate treatment strategies with NOACs in atrial fibrillation patients in need of further ablation or intervention
  • Review the reversal options open to individuals experiencing a bleeding event whilst on treatment with a NOAC

Target Audience

  • Cardiologists
  • Interventional Cardiologists

More from this programme

Part 1

When to Initiate a NOAC and Patient Suitability (data presentation)

An overview of current guidelines

Part 2

Overview of Safety and Cardiovascular Data

a. Safety and cardiovascular data from RCTs b. Real-world and meta-analyses

Part 3

Dealing with Complications:

Major bleeding events and reversal

Part 4

Discussion on Safety Rates and Patient Suitability (Panel Discussion Session)

Panel recommendations of NOAC choice according to different patient populations

Part 5

NOAC Use with Ablation and Intervention

a. Guideline recommendations and current trends b. Use of NOACs with ablation in Japan: clinical data

Part 6

Discussion on the Current Use of NOACs in Japan

a. Use in elderly/very old pts b. Under-dosing of NOACs c. Current unmet needs

Faculty Biographies

John Eikelboom

John Eikelboom

Associate Professor

Dr John Eikelboom is an Associate Professor in the Department of Medicine at McMaster University in Hamilton , Ontario . 

Dr Eikelboom earned his MBBS degree at the University of Western Australia Medical School, Australia and he completed training in Internal Medicine and Haematology at Royal Perth Hospital , Australia and trained in Epidemiology and Thrombosis Medicine at McMaster University . 

Dr Eikelboom’s current research focuses on variable response to antiplatelet therapy, antithrombotic therapy in atrial fibrillation, and mechanisms and prognosis of bleeding. He has published more than 150 peer-reviewed papers. He is a member of the Editorial Board for Stroke and on the Advisory Board for the Journal of Thrombosis and Haemostasis.

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Ken Okumura

Ken Okumura

Prof. Ken Okumura served as a Professor of Medicine at Hirosaki University School of Medicine from 1996 to 2016. He also served as a President of the Japanese Heart Rhythm Society (JHRS) from 2012 to 2016. He is now working at Saiseikai Kumamoto Hospital Cardiovascular Center, Japan, while providing the latest interventional treatments for cardiac arrhythmias especially catheter ablation of AF. His main interests include pharmacological and non-pharmacological treatments of cardiac arrhythmias, catheter ablation of persistent AF, and oral anticoagulant therapy for stroke prevention in AF especially in the elderly AF patients.

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Jan Steffel

Jan Steffel

Senior Consultant in Electrophysiology and Devices

Professor Jan Steffel is a Cardiologist and Senior Consultant in Electrophysiology and Devices at the Hirslanden Clinic in Zurich and Professor of Cardiology at the University of Zurich.

He has over 150 publications in international and national journals and is board-certified in Internal Medicine and Cardiology.  He was Associate Editor for the European Heart Journal from 2012 and became Deputy Editor in 2017. He is a member of the Foederatio Medicorum Helveticorum (FMH), Swiss Society for General Internal Medicine (SGAIM), Swiss Society for Cardiology (SGK) and European Society of Cardiology (ESC).

Since 2012, Prof Steffel has been involved with the

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Stefan H Hohnloser

Stefan H Hohnloser

Professor of Medicine and Cardiology

Stefan H Hohnloser is Professor of Medicine and Cardiology at the Johann Wolfgang Goethe University in Frankfurt, Germany, where he is the Head of the Department of Electrophysiology. His primary research interests include sudden cardiac death and its prevention by device therapy.

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