NOTION 8 Years Follow-Up: Long-Term Follow-Up After Medtronic TAVI Versus SAVR In Patients At Lower Surgical Risk

Published: 19 Jan 2021

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In this video, you will understand the long-term outcome of the randomized NOTION trial comparing TAVI and SAVR in low risk patients.


  • Appreciate how supra-annular valve position can impact on long-term valve durability
  • Recognise the importance of transvalvular gradients and opening area on valve performance and structural valve deterioration
  • Understand the difference between various interpretations of structural valve deterioration
    (SVD vs. modified SVD vs. bioprosthetic valve failure)


Introduction and Objectives

Long-term follow-up after TAVI versus SAVR in patients at lower surgical risk –

The NOTION trial
Trial objectives
Patient demographics
Outcome data (mortality, combined endpoint, hemodynamics)
SVD, modified SVD and bioprosthetic failure

Discussion Point 1: Impact of supra-annular valve position on long-term valve performance
Discussion Point 2: Differences in SVD, modified SVD, biprosthetic valve failure
Discussion Point 3: Impact of patient prosthesis mismatch on surgical outcome / bioprosthetic valve sizes
Discussion Point 4: Surgical view on long-term NOTION data, differences between supra-annular and intra-annular devices

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