Aortic Stenosis and TAVI: New Trials, Devices and Data

Published: 02 October 2023

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Overview

In this video series, first presented at the ESC Congress 2023 held in Amsterdam, Prof Roxana Mehran, Dr Antoinette Neylon, Dr Martin Swaans, Prof Raphael Rosenhek and Prof Haim Danenberg discuss the Expand II TAVR pivotal trial design and the rational for investigating the treatment of moderate aortic stenosis patients with Evolut™ TAVI, provide practical Echo imaging recommendations to improve aortic stenosis diagnosis in challenging cases, as well as presenting the latest TAVI clinical data on durability, including an outlook of new evidence to expect next and the innovative Evolut™ FX TAVI system.

 

Click here to watch the NOTION: Nordic Aortic Valve Intervention ESC 2023 Wrap-up.

 

This programme is supported by

Learning Objectives

  • Learn more about the benefits of detecting aortic stenosis earlier and discover the rationale for the Expand II TAVR pivotal trial
  • Appreciate a case-based discussion to enhance your Echo diagnosis of aortic stenosis in challenging patients and anatomies
  • Discover new TAVI trials, devices and data on durability and indications

Target Audience

  • General Cardiologists
  • Interventional Cardiologists

More from this programme

Part 1

Welcome and Introduction

Welcome and introduction of the presenters and learning objectives by Prof Mehran and Dr Neylon.
 

Part 2

Treating Aortic Stenosis Earlier – What You Need to Know

Dr Swaans presents the rational for considering the treatment of moderate aortic stenosis patients and the Expand II TAVR pivotal trial design.

Part 3

Panel Discussion – Treating Aortic Stenosis Earlier – What You Need to Know

Panel discussion about moderate aortic stenosis and the challenges to identify the symptomatic patients, as well as questions about the Expand II TAVR pivotal trial design.

Part 4

Overcoming Echo Acquisition Challenges in Aortic Stenosis

Prof Rosenhek presents practical echo imaging tips on how to enhance the echo diagnosis of aortic stenosis in challenging patients.

Part 5

Panel Discussion – Overcoming Echo Acquisition Challenges in Aortic Stenosis

Panel discussion addressing questions on how to avoid the underdiagnosis of patients, especially in women and the importance of calcium scoring as well as the pencil probe to see the jet easier. Furthermore the panel discuss which patients we expect to be seeing in the Expand II TAVR pivotal trial for moderate aortic stenosis patients.

Part 6

TAVI Evolut-ion – Data and New Devices

Prof Danenberg presents hot off the press, new TAVI data including the sub analysis of the 3 year results of the Evolut Low Risk trial of patients below 75 years of age. He explains the differences of existing TAVI valve devices and how their design variances lead to equally different durability outcomes known so far. Furthermore he presents the new Evolut™ FX TAVI system and prospective TAVI data coming up.

Part 7

Panel Discussion – TAVI Evolut-ion – Data and New Devices

Panel discussion about the treatment of younger patients and which valve to consider, Prof Danenbergs’ experience with the new Evolut™ FX TAVI system and the importance of the commissural alignment and other innovations to help improve TAVI patient treatment outcomes.

Part 8

Take Home Message

Dr Neylon summarises the scientific session and shares the take home messages.
 

Faculty Biographies

Roxana Mehran

Roxana Mehran

Professor of Medicine, Cardiology and Professor of Population Health Science and Policy

Roxana Mehran is Professor of Medicine, Cardiology and Professor of Population Health Science and Policy at the Icahn School of Medicine at Mount Sinai in New York. She is also Director of Interventional Cardiovascular Research and Clinical Trials at The Zena and Michael A Weiner Cardiovascular Institute at Mount Sinai Hospital where, over the past 5 years, she has led the development of a globally respected data and clinical coordination centre to support large, multicentre, multinational clinical trials designed to help improve outcomes and quality of life for patients undergoing interventional cardiovascular procedures. In recent years, her work has had a special emphasis on gaining a deeper understanding of anticoagulation and antiplatelet regimens post angioplasty and transcatheter valve replacement; and collection and interpretation of sex-specific data in cardiovascular clinical trials.

Roxana serves on editorial board of multiple peer reviewed journals, including …

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Antoinette Neylon

Antoinette Neylon

Interventional Cardiologist

Dr Antoinette Neylon is an Interventional Cardiologist at Cardiovascular Institute Paris Sud, Massy, FR.

She acquired her title of Bachelor of Medicine and Bachelor of Surgery in National University of Ireland.

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