Improving Atrial Fibrillation Treatment Outcomes With First Line Cryoablation







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The objective of this session is to discuss the significance of the 2020 ESC guidelines on atrial fibrillation (AF) and new evidence demonstrating the benefits of early rhythm control and first-line cryoablation. This online session will feature results from the EAST, CRYO-FIRST and STOP AF First, and EARLY AF trials.

To provide background information and maximise the learning potential of this session, we recommend attendees refer to the following videos in advance of the broadcast:

 A summary of the EARLY-AF, STOP AF First, and CRYO-FIRST clinical trials

 Highlights from the 2020 ESC guidelines on AF management

Attendees will be able to submit questions for the faculty in advance and throughout the broadcast.

Performed By:

Carina Blomström-Lundqvist

Carina Blomström-Lundqvist

Jason G Andrade

Jason G Andrade

Yassir Javaid

Yassir Javaid

Magnus Forsgren

Magnus Forsgren

Moderated By:

Paulus Kirchhof

Paulus Kirchhof

This webinar is supported by:


18:00 – 18:02

- Prof. Paulus Kirchhof

18:02 – 18:12

Highlights from the 2020 ESC Guidelines for the Diagnosis and Management of Atrial Fibrillation
- Prof Carina Blomström-Lundqvist

18:12 – 18:22

Early Rhythm Control Therapy Improves AF Patient Outcomes: Key Findings from the EAST Trial
- Prof Paulus Kirchhof

18:22 – 18:32

Safety & Effectiveness of First line Cryoablation: New Evidence: EARLY-AF, CRYO-FIRST, and STOP AF First trials
- Prof Jason Andrade

18:32 – 18:50

Optimising the AF Treatment Pathway
- Moderated Discussion, Dr Yassir Javaid & Dr Magnus Forsgren

18:50 – 18:58


18:58 – 19:00

Conclusion - Prof Paulus Kirchhof

Target Audience

  • This educational session primarily targets general cardiologists and primary care physicians.

Learning Objectives

  • AF progression and the importance of early treatment (e.g. EAST - AFNET trial)
  • Key updates to the ESC guidelines on AF management
  • New evidence on first line cryoablation: CRYO-FIRST, STOP AF First, and EARLY AF trials
  • Optimising the treatment pathway and improving the standard of care for AF patients

Faculty Biographies

Carina Blomström-Lundqvist

Carina Blomström-Lundqvist

Dr Carina Blomström-Lundqvist is Professor of Cardiology at the Department of Cardiology, Institution of Medical Science, Uppsala, Sweden.

Dr Blomström-Lundqvist graduated in medicine in 1976, she went on to specialize in cardiology and internal medicine, and started research on haemodynamics and myocardial metabolism in patients with dilated cardiomyopathy. With the developments in electrophysiology she switched her research interest towards arrhythmias and after 3 years she defended her PhD thesis on the diagnostic and prognostic implications of arrhythmogenic right ventricular dysplasia in 1987 in Gothenburg, Sweden.

At Uppsala, Dr Blomström-Lundqvist has become research leader for the arrhythmia unit, mainly focusing on research related to atrial fibrillation (AF). In collaboration with the Department of Thoracic Surgery, procedures for Maze surgery followed by thoracoscopy epicardial atrial fibrillation ablations were initiated.

Dr Blomström-Lundqvist has also served as scientific secretary to the Swedish Society of Medicine and is presently chair of the Heart Rhythm Group of the Swedish Society of Cardiology.

Dr Blomström-Lundqvist is a member of the AER editorial board.

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Jason G Andrade

Jason G Andrade

Dr Jason Andrade is a Cardiac Electrophysiologist at Vancouver General Hospital in Canada, with joint appointment at St Paul’s Hospital and the Montreal Heart Institute. He is an Associate Professor of Medicine at the University of British Columbia (UBC), and an Adjunct Professor at the Université de Montréal. Dr Andrade is the Director of the Electrophysiology Program at VGH, as well as Head of the Atrial Fibrillation Clinic at VGH. He also serves as co-chair of the Canadian Cardiovascular Society Atrial Fibrillation Guidelines committee, and serves as the medical lead for the atrial fibrillation care in the province of British Columbia. He previously served as chair of the education committee for the Canadian Heart Rhythm society.

Dr Andrade is the principal investigator of two ongoing multicenter clinical trials on cryoablation (the CIRCA-DOSE study and the EARLY-AF program). He has authored or co-authored over 120 scientific publications, predominantly in the domain of atrial fibrillation. He is also the author of a handbook of cardiac electrophysiology, a handbook of electrocardiogram interpretation, and several chapters related to atrial fibrillation ablation and cardiac cryoablation.

Dr Andrade is a graduate of McMaster University (BSc; Summa Cum Laude) and the University of Ottawa (MD, Magna Cum Laude). He completed his Internal Medicine residency and Cardiology fellowship training at the University of British Columbia and a clinical and research fellowship in Cardiac Electrophysiology at the Montreal Heart Institute.

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Yassir Javaid

Yassir Javaid

Dr Javaid qualified from Cambridge University and completed his GP VTS training in Northampton. He has an interest in cardiology and echocardiography and was a clinical lead in the Northamptonshire Community Cardiology service, which had a focus on patients with heart failure and valve disease.

Dr Javaid was named Pulse “GP of the Year” in 2015 for his work in reducing stroke emergency admissions in the East Midlands. He is also a council member of the British Heart Valve Society, accredited member of the British Society of Echocardiography and on the editorial board for the British Journal of Cardiology.

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Magnus Forsgren

Magnus Forsgren

Dr Magnus Forsgren, Head Physician, Cardiology Clinic, Falun Hospital, Sweden

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Paulus Kirchhof

Paulus Kirchhof

Prof Kirchhof is the Director of the Institute of Cardiovascular Sciences at the University of Birmingham. Prof Kirchhof research includes novel molecular mechanisms of heart disease that can be leveraged to develop personalised treatment approaches to common cardiovascular diseases.

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Key References

1. Andrade, J. et al., 2020. Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation. New England Journal of Medecine

2. Wazni et al., 2020. Cryoballoon Ablation as Initial Therapy for Atrial Fibrillation. New England Journal of Medecine

3. Hindricks, G. et al., 2020. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS). European Heart Journal. 00, 1-126

4. Kuniss et al. Presented at the German Cardiac Society conference DGK 2020

5. Chierchia, GB. et al., 2020. Quality of Life Measured in First-Line Therapy During the CRYO-FIRST Study: A Comparison Between Cryoballoon Catheter Ablation Versus Antiarrhythmic Drug Therapy. Poster presented at the 2020 ESC Congress – The Digital Experience

6. Hermida et al., 2020. Cryoballoon catheter ablation versus antiarrhythmic drugs as a first-line therapy for patients with paroxysmal atrial fibrillation: Rationale and design of the international Cryo-FIRST study. Am Heart J. 222:64-72

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