01

Oct

2020

18:00

BST

Webinar

Impacting MR and TR Patient Outcomes with the PASCAL Repair System

Overview

This studio-based interactive broadcast will bring together a world-leading faculty for a series of presentations, engaging discussions and a live case, led by Prof Lurz from the renowned Heart Center Leipzig, in which he will demonstrate the PASCAL repair system for the treatment of Mitral Regurgitation. Whilst the focus will be on MR treatment, our faculty will also offer expert insight to TR treatment.

Moderated by Prof Nicolas Van Mieghem, from Erasmus Medical Center, Rotterdam, this dynamic event will keep its audience central to proceedings with the chance to engage with the faculty throughout with live Q&As, and polls to share the latest audience insights to the challenges, opinions and approaches in mitral and tricuspid valve disease repair.

Pipeline products from Edwards Lifesciences will also be shown.

This webinar is supported by:

Agenda

Presentation: Where are We Now with the Treatment of Mitral & Tricuspid Regurgitation?

Prof van Mieghem

Presentation: Residual MR Matters

Dr Praz

Presentation: 1-year CLASP Study Outcomes and Real World Experience with the PASCAL Repair System for MR

Dr Lubos

Discussion

All

Presentation: Leveraging the PASCAL Repair System Technology to Treat TR

Dr von Bardeleben

Presentation: Clinical Evidence with the PASCAL Repair System on the Treatment of TR

Dr von Bardeleben

Discussion

All

Presentation: PASCAL Repair System for TR - Case Presentationss

Dr Markovic

Discussion

All

LIVE Case - PASCAL Mitral

Prof Lurz

Summary - Session evaluation and key learnings

Prof van Mieghem

Learning Objectives

  • To show latest evidence and developments on what is new in mitral and/or tricuspid valve disease repair
  • To discuss the clinical evidence of PASCAL repair system in the treatment of MR and TR
  • To learn from case examples how PASCAL repair system improves outcomes of patients with TR
  • To enhance practical learning through a step-by-step LIVE demonstration of percutaneous mitral leaflet repair with PASCAL repair system

Faculty Biographies


Fabien Praz

Fabien Praz

Dr Fabien Praz is an interventional cardiologist at Bern University Hospital, Switzerland. His top areas of expertise are Mitral Valve Regurgitation, Tricuspid Regurgitation, Mitral Stenosis, and Aortic Valve Stenosis.

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Dr Sinisa Markovic

Dr Sinisa Markovic

University Clinic Ulm, Germany

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Dr Edith Lubos

Dr Edith Lubos

University Medical Center Hamburg-Eppendorf, Germany

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Ralph Stephan von Bardeleben

Ralph Stephan von Bardeleben

Prof Ralph Stephan von Bardeleben is the Head of the Centre of Structural Heart Disease Interventions and the Heart Valve Centre in Mainz, Germany. 

Prof Bardeleben is Past-President of the German working group on Echocardiography of the German Society of Cardiology and a member of several medical societies. He serves on the Clinical Program commission and at your region program of the ESC and is a reviewer for several peer-reviewed journals. Newly elected co-editor-in-chief of Echocardiography Journal.

He participates as PI, steering committee member and core laboratory in several medical device trials, including a German Federal Institute for Drugs and Medical Devices (BfArM)-approved first- or early-in-human medical device implant trials.

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Philipp Lurz

Philipp Lurz

Prof Philipp Lurz is Deputy Head of the Department at Heart Center Leipzig, Germany, a position he has held since 2018. Previously, Prof Lurz was a Clinical Research Fellow at Great Ormond Street Hospital for Children NHS Foundation Trust. He completed his education at the University of Leipzig, and is a member of the German Society of Cardiology. Prof Lurz is widely published in leading international peer-reviewed journals.

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Nicolas M Van Mieghem

Nicolas M Van Mieghem

Personal History

From an early age, Professor Nicolas Maria Van Mieghem decided to pursue a career that would help others. “I enjoy the feeling of being able to help someone or do something important for them. I wanted to enter a profession that would channel my energy— I was always a busy child,” he says. 

A budding athlete, he was a member of Belgium’s national swimming team but soon realized that medicine was his true calling. His father was a general cardiologist and one of his biggest influences early in his career.

Professor Van Mieghem initially intended to train as a cardiac surgeon but decided to specialise in interventional cardiology instead, following advice from a mentor. This decision was cemented when he read the first-in-human case report of transcatheter aortic valve implantation (TAVI) in Circulation by Alain Cribier in 2002. 

His mantra is mens sana in corpore sano (a healthy mind in a healthy body). He remains an avid swimmer and cyclist and follows a number of professional sports. “Like all Belgians, I love to watch the big cycling events—the classic cycle races, the Tour de France, the Giro d’Italia, the Vuelta a España,” he says. 

Van Mieghem believes that a great cardiologist genuinely cares for their patients. He names Gary Roubin, Dr Manu Malbrain and Professor Patrick Serruys among his mentors. 


 

Academic History

 

In 2007, Professor Van Mieghem obtained his medical and cardiology degrees at the Catholic University of Leuven, Belgium. He completed fellowships in interventional cardiology in Ziekenhuis Oost-Limburg Genk, Belgium, Lenox Hill Hospital, New York, US and Erasmus Medical Center, Rotterdam, the Netherlands.2 His PhD focused on transcatheter valve therapies.3

His current research focuses on cerebral embolic protection during TAVI and the search for improved large bore closure devices. He works actively in expanding TAVI indications, most notably TAVI as a means to further unload the left ventricle in heart failure patients with moderate aortic stenosis (the TAVR UNLOAD trial). Professor Van Mieghem is also involved in the development and dispersion of mechanical circulatory support (MCS) devices as well as transcatheter mitral and tricuspid repair techniques. In terms of imaging and preprocedural planning, his research has covered computed tomography (CT)-derived 3D modelling and printing.

Professor Van Mieghem has received institutional research grant support from Abbott Vascular, Boston Scientific, Edwards Lifesciences, Medtronic, Daiichi-Sankyo, PulseCath BV and Abiomed.7

 

Career Overview

After his fellowships, Professor Van Mieghem joined the department of interventional cardiology at the Thorax Centre, Erasmus Medical Center, as a senior staff member in February 2010. He is now working there as a Full Professor of Interventional Cardiology.2

As well as his involvement in the percutaneous coronary interventions and structural heart programs, he has published and co-authored over 350 scientific papers in peer-reviewed journals.4 Professor Van Mieghem is a principal investigator and steering committee member in multiple ongoing international trials, evaluating various coronary and transcatheter valve technologies.3 He is a Fellow of the European Society of Cardiology (FESC) and is currently Medical Director of the department of Interventional cardiology at the Thorax Centre.3

 

Career Timeline

  • 2008 - 2009: Fellow, Interventional Cardiology, Lenox Hill Hospital
  • 2010: Joined the senior staff, Interventional Cardiology, Thorax Centre, Erasmus MC
  • 2014: Clinical Director, Interventional Cardiology, Erasmus MC
  • 2019 - Present: Full Professor, Interventional Cardiology, Erasmus MC
  • Present: Medical Director, Interventional Cardiology, Thorax Centre 

 

Areas of Speciality4

  • Interventional Cardiology
  • Transcatheter Heart Valve Interventions

 

Sources

  1. https://cardiovascularnews.com/nicolas-van-mieghem/
  2. https://esc365.escardio.org/Person/418700-dr-van-mieghem-nicolas 
  3. https://www.radcliffecardiology.com/authors/nicolas-m-van-mieghem 
  4. https://www.ecri-trials.com/faculty/nicolas-van-mieghem/ 
  5. https://www.cardialysis.com/core-lab/supervising-cardiologists/ 
  6. https://www.worldcat.org/title/transcatheter-aortic-valve-therapies-from-cutting-edge-to-mainstream-catheter-gebonden-aortaklep-implantatie/oclc/892053833 
  7. https://www.jacc.org/doi/pdf/10.1016/j.jcin.2020.12.021 

 

 Prof Van Mieghem is on the ICR3 Editorial Board.

 

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