CCM® Around the World








This live online webinar is an educational program designed to share the latest updates on a breakthrough device-based therapy for the treatment of moderate to severe heart failure. While cardiac contractility modulation using the Optimizer® device has been well-studied, published and widely available in Europe for a number of years, it was only recently approved in the US. The use of CCM® therapy continues to expand rapidly – which makes now a perfect time to bring the world's most experienced investigators and providers with extensive clinical experience together to discuss the current and future place CCM® may take in the treatment of heart failure.

Moderated By:

Thomas M Helms

Thomas M Helms

Karl-Heinz Kuck

Karl-Heinz Kuck

William T Abraham

William T Abraham

Daniel Burkhoff

Daniel Burkhoff

Frieder Braunschweig

Frieder Braunschweig

Jürgen Kuschyk

Jürgen Kuschyk

This webinar is supported by:


6:00pm CEST

Opening - Dr Thomas M Helms, Hamburg, Germany

6:05pm CEST

A look behind the scientific curtain - clarifying the core operating principles of CCM® therapy (HFpEF/HFrEF) – Dr William T Abraham, Columbus, OH, US

6:20pm CEST

What's next for CCM® therapy and how might it influence our work? – Prof Daniel Burkhoff, New York, NY, US

6:30pm CEST

Finding the fit for CCM® therapy - Ensuring appropriate patient identification and selection? – Prof Frieder Braunschweig, Stockholm, Sweden

6:40pm CEST

Case studies – real world observations of CCM® in action – PD Dr Jurgen Kuschyk, Mannheim, Germany

6:55pm CEST

Closing – Prof Dr Karl-Heinz Kuck, Hamburg, Germany

Learning Objectives

  • Become aware of the history of Impulse Dynamics and it's founding by a renowned scientist inventor.
  • Appreciate the extensive scientific endeavours that resulted in the outcomes that have driven approval by the various regulatory authorities.
  • Learn about the mode of action that underpins CCM® therapy.
  • Understand the clinical path forward for CCM® therapy.
  • Gain an understanding of appropriate patient identification and selection.
  • Share patient experiences via case studies presented by the physician with the most extensive clinical experience in the world.

Faculty Biographies

Thomas M Helms

Thomas M Helms

Hamburg, DE (Co-Chair)
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Karl-Heinz Kuck

Karl-Heinz Kuck

Prof Karl-Heinz Kuck is the Medical Director at LANS Cardio Hamburg. For many years, he was head of the Department of Cardiology at the Asklepios Klinik St. Georg in Hamburg. In addition, Prof Kuck was President of the European Heart Rhythm Association and President of the German Society for Cardiology. 

He has earned several prizes for his work, including the Science Prize of the Gertrud Spitz Foundation and a silver badge of honor from the German Society for Cardiology – Heart and Circulatory Research. Prof Dr Kuck is also Section Editor –  Clinical Electrophysiology and Ablation at Arrhythmia & Electrophysiology Review.

Prof Kuck is on the AER editorial board.

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William T Abraham

William T Abraham

Personal History

Dr William Tober Abraham was born in 1959. He is a renowned Professor of Internal Medicine at Ohio State University College of Medicine and the Chief Medical Officer at V-Wave Ltd, an Israel-based MedTech company that focuses on developing implantable technologies for patients with heart failure.4  

He lives in Powell, Ohio, USA with his wife, Darcy Kristine Abraham. He has been practicing medicine for 35 years and is fluent in English, Spanish and French.10 

Academic History

After graduating magna cum laude from the University of Pittsburgh in 1982, Dr Abraham received his MD from Harvard Medical School in 1986.5, 11 He then completed his residency in internal medicine and fellowships in cardiology and heart failure/cardiac transplantation at the University of Colorado Health Sciences Center in 1990.5 

His areas of research include the role of the kidney in heart failure, neurohormonal mechanisms in heart failure, sleep-disordered breathing in heart failure and clinical drug and device trials in heart failure and cardiac transplantation.8 Dr Abraham’s research has led to the approval and adoption of new heart failure therapies including beta-blockers, natriuretic peptides, cardiac resynchronization therapy, ultrafiltration, implantable hemodynamic monitoring, transvenous phrenic nerve stimulation, cardiac contractility modulation, baroreflex activation therapy and mitral valve repair. 

Career Overview

At the Ohio State University College of Medicine, Dr Abraham is a Professor of Internal Medicine (Physiology and Cell Biology). His previous roles at the institution include Chief of the Division of Cardiovascular Medicine, Deputy Director of the Dorothy M Davis Heart and Lung Research Institute, Associate Dean for clinical research and Medical Director of the Clinical Trials Management Office at the Medical Center.3

After over 16 years as Director of the Division of Cardiovascular Medicine, he joined early-stage MedTech company V-Wave Ltd as Chief Medical Officer.3 V-Wave is developing an implantable interatrial shunt device for treating advanced heart failure (HF) and pulmonary arterial hypertension (PAH).3 Dr Abraham is a key member of this team, bringing his vast clinical trial experience with drugs and devices for heart failure to the ongoing project.

He has held faculty and leadership positions at the University of Colorado, the University of Cincinnati and the University of Kentucky and has Board Certifications in Internal Medicine, Cardiovascular Medicine, Advanced Heart Failure and Transplant Cardiology.2, 6 

He is co-editor of the leading textbook Heart Failure: A Practical Approach to Treatment which was originally published in 2007.2 The author of more than 1,000 original papers, abstracts, book chapters and review articles, he is also an editorial board member of several major journals including Congestive Heart Failure and Journal Watch Cardiology.

He has received grants from the National Institutes of Health (NIH), the American College of Cardiology (ACC) and the Aetna Quality Care Foundation.6 Dr Abraham has also participated as Principal Investigator in more than 100 multicenter clinical drug and device trials.3

Career Timeline

  • 1987 - 1990: Residency in Internal Medicine at the University of Colorado Health Sciences Center 
  • 1990 - 1993: Fellowship in Cardiovascular Disease at the University of Colorado Health Sciences Center 
  • 2002 - Present: The Ohio State University Wexner Medical Center
  • 2002 - 2019: Director, Division of Cardiovascular Medicine
  • 2009 - 2019: Chair of Excellence in Cardiovascular Medicine
  • 2012 - 2019: Medical Director, Clinical Trials Management Office
  • 2014 - 2019: Associate Dean for Clinical Research
  • 2016 - Present: College of Medicine Distinguished Professor
  • 2002 - Present: Professor of Medicine, Physiology and Cell Biology
  • 2012 - Present: Board Member at Respicardia Inc
  • 2019 - Present: Chief Medical Officer at V-Wave
  • 2021 - Present: Board Member at Scpharmaceuticals Inc


  • Castle Connolly Regional Top Doctors: 1st Edition
  • Columbus Monthly: One of the ‘Best Doctors in America’ for 18 consecutive years
  • Top 1% on the Highly Cited Researchers list by Clarivate Analytics (formerly Thomson Reuters)
  • Named One of The World’s Most Influential Scientific Minds by Clarivate Analytics
  • 2016 Ohio State College of Medicine Distinguished Professor
  • 2017 Distinguished Scientist Award from the American College of Cardiology
  • Among the top 10% of physicians nationally in patient satisfaction

Areas of Speciality

  • Cardiovascular
  • Heart Failure7
  • Heart Disease2




Dr William T Abraham is an Editorial Board member of Cardiac Failure Review.

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Daniel Burkhoff

Daniel Burkhoff

New York, NY, US

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Frieder Braunschweig

Frieder Braunschweig

Stockholm, SE
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Jürgen Kuschyk

Jürgen Kuschyk

Mannheim, DE
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