Superiority data in DES – are all stents non-inferior?

Published: 14 September 2021

  • Views:

    Views Icon 266
  • Likes:

    Heart Icon 7

Overview

In the field of drug eluting stents, we have grown used to non-inferiority studies. Two recent publications highlight that one stent may offer real clinical benefits over other contemporary DES. Listen to the trial investigators talk about these two new studies with the potential to change our understanding of the DES landscape. 

 

“The history of drug eluting stents has taught us that we cannot really talk about class effect when we are addressing the results of one single drug eluting stent, because the DES is unique in that it has a specific platform, polymer, and drug. Therefore, if some results apply to one kind of drug eluting stent, they do not necessarily apply to DES that have some similar components.” Dr. Tullio Palmerini

 

BIOSTEMI RCT  is the first direct comparison between two newer generation DES in patients with acute ST-segment elevation myocardial infarction (STEMI). Learn about the superiority of Orsiro in STEMI  regarding Target Lesion Failure at 24 months.

 

The Network Meta-Analysis  on Target Lesion Failure With Current Drug-Eluting Stents conducted by Taglieri et. al. analyzed 99’039 patients in 77 randomized controlled trials (RCT) comparing Orsiro and 9 other currently used DES. See the key learnings and find out more about Orsiro having the highest probability (70.8%) to rank as the best stent, based on SUCRA (Surface Under the Cumulative Ranking Curve) score.

 

Dr. Juan F. Iglesias (Co-Principal Investigator of the BIOSTEMI RCT, Geneva University Hospitals, Geneva, Switzerland), presents the clinical data results at 24 months and speaks about the superiority in STEMI patients and its benefits for Orsiro DES. 

 

Dr. Tullio Palmerini (Principal Investigator of the Taglieri et a. Network Meta-Analysis, Policlinico S. Orsola, Bologna, Italy) presents the outcome of the recent network meta-analysis on Target Lesion Failure With Current Drug-Eluting Stents . 

 

Dr. David Kandzari reviews the long-term outcomes of the BIOFLOW-V randomized controlled trial, comparing the outcomes of Orsiro ultrathin-strut DES to the Xience thin-strut DES. As principal investigator, he shares his insights from the trial and its implications to everyday practice.

 

Intended for healthcare professionals only. This program is supported by BIOTRONIK. Views and opinions expressed in the program belong to the authors and speakers.  Allied Health Professionals

This video series is sponsored by

More from this programme

Part 1

BIOSTEMI RCT – Superiority in STEMI

Dr Juan F. Iglesias presents the 24-month results

Part 2

Network Meta-Analysis on Target Lesion Failure With Current Drug-Eluting Stents (Taglieri et. al.)

Dr Tullio Palmerini speaks about the key findings of the network meta-analysis of 77 RCTs and more than 99’000 patients

Part 3

Final 5-year Outcomes from the Randomized BIOFLOW-V Trial

Dr David Kandzari reviews the long-term outcomes of the BIOFLOW-V randomized controlled trial, comparing the outcomes of Orsiro ultrathin-strut DES to the Xience thin-strut DES. As principal investigator, he shares his insights from the trial and its implications to everyday practice.

Faculty Biographies

Juan F Iglesias

Juan F Iglesias

MD

Dr Juan F. Iglesias is an interventional cardiologist at Geneva University Hospitals and Privat Docent at the University of Geneva, Switzerland. He obtained his medical degree at Lausanne University Hospitals in Switzerland and completed his general and interventional cardiology training at the same institution, at the London Chest Hospital (Barts Health NHS Trust, London, United Kingdom) and at Hammersmith Hospital (Imperial College Healthcare NHS Trust, London, United Kingdom). He is board certified in general cardiology at Lausanne University Hospital and specialized in interventional cardiology with a focus on complex and high-risk percutaneous coronary interventions including chronic total occlusions, intravascular imaging, and invasive coronary physiology. Dr Iglesias works as a consultant in interventional cardiology at Geneva University Hospitals. He is fellow of the European Society of Cardiology (FESC) and the American College of Cardiology (FACC). Having…

View full profile
Tullio Palmerini

Tullio Palmerini

Policlinico S.Orsola, Bologna, Italy

Dr Tullio Palmerini is an interventional cardiologist at Policlinico S.Orsola, Bologna, Italy.

He graduated in Medicine in 1992 at “La Sapienza University”, in Rome; Italy, and got the specialty in Cardiology in 1996 at “Alma Mater University”, in Bologna, Italy.

He did a research fellowship in 1998 at Mount Sinai Hospital, New York and a clinical fellowship in coronary intervention in 2009 and structural heart disease in 2015 at Columbia University, New York.

He is author or coauthor of more than 170 publications in major medical journals such as Lancet, Journal of American College of…

View full profile