A Peek into the Future – Repair and Replacement of the Mitral and Tricuspid Valves with the Edwards Portfolio: On-demand Programme

Published: 19 March 2021

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This on-demand version of the broadcast 'A Peek into the Future – Repair and Replacement of the Mitral and Tricuspid Valves with the Edwards Portfolio' comprises an internationally-respected faculty, as they review the PASCAL platform focusing on the recently CE mark approved PASCAL Ace implant system for the treatment of mitral and tricuspid regurgitation. Under the stewardship of programme Chair, Prof Nicolas van Mieghem, Erasmus Medical Center, Rotterdam, this programme examines the role of the PASCAL platform the the treatment of MR, the PASCAL Ace Implant System in the treatment of TR, valve replacement with EVOQUE, and includes a live procedure from Heidelberg University Hospital to best enhance practical learnings.


Pipeline products for tricuspid transcatheter replacement from Edwards Lifesciences will be shown and briefly discussed.

This programme was supported by

Learning objectives

  • Outline the pathogenic nature and clinical risk of extended exposure to elevated LDL-C
  • Describe the clinical challenges in achieving guideline-based LDL-C goals
  • Compare and contrast LDL-C lowering therapies


  • Interventional Cardiologists
  • General Cardiologists
  • Heart Failure Specialists
  • Echocardiographers
  • Nurses

More from this programme

Part 1

Introduction – A Peek into the Future Repair and Replacement of the Mitral & Tricuspid Valves With the Edwards Portfolio

Prof Van Mieghem provides a brief introduction to proceedings, and examines the impact of Atrio-Ventricular Valve Regurgitation, the limitations of surgery in functional / secondary MR and TR, and the potential of transcatheter repair.

Part 2

The PASCAL Platform – Successfully and Confidently Treat MR

In this presentation, Prof Peter Ludike reviews the PASCAL repair system as a novel and differentiated therapy for patients, and examines the results of the CLASP study at one-year follow-up, in addition to real world experience.

Part 3

The PASCAL Ace Implant System – Therapy to Successfully Treat TR

In this presentation, Prof Philipp Lurz reviews the PASCAL repair system, concluding that it is both a novel and differentiated therapy for patients with TR. He discusses both first-in-human and single centre experience.

Part 4

Looking into the Future – Valve Replacement with the EVOQUE

In this overview of EVOQUE Valve replacement system for TR, Dr RS von Bardeleben​ notes that it utilises an entirely percutaneous approach for TTVR, and examines first-in-human experience.

Part 5

Case – PASCAL Ace Implant System for the Treatment of TR

Prof Philip Raake and colleagues present a case from University Hospital of Heidelberg, Germany.

Faculty Biographies

Philip Raake

Philip Raake

Head, HFU Centre, Department of Cardiology, Heidelberg University Hospital, Germany

Prof Philip Raake is a senior physician who leads the HFU centre at the Department of Cardiology at Heidelberg University Hospital. He also runs the Interventional HF programme.

Prof Philip Raake attended medical school at the Ludwig-Maximilians University in Munich. Between 2006 and 2008, Prof Raake worked at the Center for Translational Medicine, under the direction of Prof Walter Koch, at the Thomas Jefferson University, Philadelphia.

In 2008 Prof Raake returned to Germany, where his established the first university Advanced Heart Failure Unit in Germany focusing on optimised care in advanced HF. He has authored or co-authored several papers in leading peer-reviewed journals on HF basic molecular mechanisms, and clinical aspects of advanced HF. He serves on several working groups for the German Society for Cardiology and the German Federal Physicians Association.

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