A Peek into the Future – Repair and Replacement of the Mitral and Tricuspid Valves with the Edwards Portfolio: On-demand Programme

Published: 19 March 2021

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This on-demand version of the broadcast 'A Peek into the Future – Repair and Replacement of the Mitral and Tricuspid Valves with the Edwards Portfolio' comprises an internationally-respected faculty, as they review the PASCAL platform focusing on the recently CE mark approved PASCAL Ace implant system for the treatment of mitral and tricuspid regurgitation. Under the stewardship of programme Chair, Prof Nicolas van Mieghem, Erasmus Medical Center, Rotterdam, this programme examines the role of the PASCAL platform the the treatment of MR, the PASCAL Ace Implant System in the treatment of TR, valve replacement with EVOQUE, and includes a live procedure from Heidelberg University Hospital to best enhance practical learnings.


Pipeline products for tricuspid transcatheter replacement from Edwards Lifesciences will be shown and briefly discussed.

This programme was supported by

Learning objectives

  • Outline the pathogenic nature and clinical risk of extended exposure to elevated LDL-C
  • Describe the clinical challenges in achieving guideline-based LDL-C goals
  • Compare and contrast LDL-C lowering therapies


  • Interventional Cardiologists
  • General Cardiologists
  • Heart Failure Specialists
  • Echocardiographers
  • Nurses

More from this programme

Part 1

Introduction – A Peek into the Future Repair and Replacement of the Mitral & Tricuspid Valves With the Edwards Portfolio

Prof Van Mieghem provides a brief introduction to proceedings, and examines the impact of Atrio-Ventricular Valve Regurgitation, the limitations of surgery in functional / secondary MR and TR, and the potential of transcatheter repair.

Part 2

The PASCAL Platform – Successfully and Confidently Treat MR

In this presentation, Prof Peter Ludike reviews the PASCAL repair system as a novel and differentiated therapy for patients, and examines the results of the CLASP study at one-year follow-up, in addition to real world experience.

Part 3

The PASCAL Ace Implant System – Therapy to Successfully Treat TR

In this presentation, Prof Philipp Lurz reviews the PASCAL repair system, concluding that it is both a novel and differentiated therapy for patients with TR. He discusses both first-in-human and single centre experience.

Part 4

Looking into the Future – Valve Replacement with the EVOQUE

In this overview of EVOQUE Valve replacement system for TR, Dr RS von Bardeleben​ notes that it utilises an entirely percutaneous approach for TTVR, and examines first-in-human experience.

Part 5

Case – PASCAL Ace Implant System for the Treatment of TR

Prof Philip Raake and colleagues present a case from University Hospital of Heidelberg, Germany.

Faculty Biographies

Nicolas M Van Mieghem

Nicolas M Van Mieghem

Medical Director

Prof Nicolas Maria Van Mieghem is an Interventional cardiologist at Thoraxcenter, Erasmus MC, Rotterdam, NL decided to pursue a career that would help others. “I enjoy the feeling of being able to help someone or do something important for them". His father was a general cardiologist and one of his biggest influences early in his career.

Prof Van Mieghem initially intended to train as a cardiac surgeon but decided to specialise in interventional cardiology instead, following advice from a mentor. This decision was cemented when he read the first-in-human case report of transcatheter aortic valve implantation (TAVI) in Circulation by Alain Cribier in 2002. Prof Van Mieghem believes that great cardiologist genuinely cares for their patients. He names Gary Roubin, Dr Manu Malbrain and Professor Patrick Serruys among his mentors. 

His current research focuses on cerebral embolic protection during TAVI and the search for improved…

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