A Peek into the Future – Repair and Replacement of the Mitral and Tricuspid Valves with the Edwards Portfolio: On-demand Programme

Published: 19 March 2021

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This on-demand version of the broadcast 'A Peek into the Future – Repair and Replacement of the Mitral and Tricuspid Valves with the Edwards Portfolio' comprises an internationally-respected faculty, as they review the PASCAL platform focusing on the recently CE mark approved PASCAL Ace implant system for the treatment of mitral and tricuspid regurgitation. Under the stewardship of programme Chair, Prof Nicolas van Mieghem, Erasmus Medical Center, Rotterdam, this programme examines the role of the PASCAL platform the the treatment of MR, the PASCAL Ace Implant System in the treatment of TR, valve replacement with EVOQUE, and includes a live procedure from Heidelberg University Hospital to best enhance practical learnings.


Pipeline products for tricuspid transcatheter replacement from Edwards Lifesciences will be shown and briefly discussed.

This programme was supported by

Learning objectives

  • Outline the pathogenic nature and clinical risk of extended exposure to elevated LDL-C
  • Describe the clinical challenges in achieving guideline-based LDL-C goals
  • Compare and contrast LDL-C lowering therapies


  • Interventional Cardiologists
  • General Cardiologists
  • Heart Failure Specialists
  • Echocardiographers
  • Nurses

More from this programme

Part 1

Introduction – A Peek into the Future Repair and Replacement of the Mitral & Tricuspid Valves With the Edwards Portfolio

Prof Van Mieghem provides a brief introduction to proceedings, and examines the impact of Atrio-Ventricular Valve Regurgitation, the limitations of surgery in functional / secondary MR and TR, and the potential of transcatheter repair.

Part 2

The PASCAL Platform – Successfully and Confidently Treat MR

In this presentation, Prof Peter Ludike reviews the PASCAL repair system as a novel and differentiated therapy for patients, and examines the results of the CLASP study at one-year follow-up, in addition to real world experience.

Part 3

The PASCAL Ace Implant System – Therapy to Successfully Treat TR

In this presentation, Prof Philipp Lurz reviews the PASCAL repair system, concluding that it is both a novel and differentiated therapy for patients with TR. He discusses both first-in-human and single centre experience.

Part 4

Looking into the Future – Valve Replacement with the EVOQUE

In this overview of EVOQUE Valve replacement system for TR, Dr RS von Bardeleben​ notes that it utilises an entirely percutaneous approach for TTVR, and examines first-in-human experience.

Part 5

Case – PASCAL Ace Implant System for the Treatment of TR

Prof Philip Raake and colleagues present a case from University Hospital of Heidelberg, Germany.

Faculty Biographies

Ralph von Bardeleben

Ralph von Bardeleben

Head of the Centre of Structural Heart Disease Interventions and the Heart Valve Centre

Prof Ralph Stephan von Bardeleben is the Head of the Center of Structural Heart Disease Interventions and the Heart Valve Center in Mainz, Germany 

Prof Bardeleben is Past-President of the German working group on Echocardiography of the German Society of Cardiology and a member of several medical societies. He serves on the Clinical Program commission and at your region program of the ESC and is a reviewer for several peer-reviewed journals. Newly elected co-editor-in-chief of Echocardiography Journal.

He participates as PI, steering committee member and core laboratory in several medical device trials, including a German Federal Institute for Drugs and Medical Devices (BfArM)-approved first- or early-in-human medical device implant trials.

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