Immediate Impact Without the Need for Thrombolytics in the Treatment of Acute Pulmonary Embolism

Published: 27 September 2022

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Overview

Pulmonary Embolism is a common disease with a challenging diagnosis. It is the third leading cause of cardiovascular mortality after heart attack and stroke. Despite high mortality rates, anticoagulation alone remains the mainstay treatment for nearly half of the patients diagnosed with PE. 20-50% of them have residual thrombus after receiving conservative treatment, developing life limiting complications after PE and increasing risk of adverse events, including recurrent VTE, heart failure, CTEPH development and death. Furthermore, today’s risk stratification does not include all proven predictors for mortality such as large and/or central clot burden, cardiogenic shock and concomitant DVT.


Why has the status quo in the treatment of acute PE not been challenged so far? How to advance the treatment and care PE patients? Watch the discussion between Professor Felix Mahfoud and Professor Nils Kucher on the current challenges and treatment options for Acute Pulmonary Embolism.

 

References:
Giri J, Sista AK, Weinberg I, et al. Interventional Therapies for Acute Pulmonary Embolism: Current Status and Principles for the Development of Novel Evidence: A Scientific Statement From the American Heart Association. Circulation 2019;140:e774–801.
Dzikowska-Diduch O, Kostrubiec M, Kurnicka K, et al. "The post-pulmonary syndrome - results of echocardiographic driven follow up after acute pulmonary embolism". Thromb Res 2020;186:30–5. 
Barnes GD, Muzikansky A, Cameron S, et al. Comparison of 4 Acute Pulmonary Embolism Mortality Risk Scores in Patients Evaluated by Pulmonary Embolism Response Teams. JAMA Netw Open 2020;3:e2010779.
Ginanjar E, Sjaaf AC, Alwi I, et al. CODE STEMI Program Improves Clinical Outcome in ST Elevation Myocardial Infarction Patients: A Retrospective Cohort Study. Open Access Emerg Med 2020;12:315–21.
Jørgensen HS, Nakayama H, Raaschou HO, et al. The effect of a stroke unit: reductions in mortality, discharge rate to nursing home, length of hospital stay, and cost. A community-based study. Stroke 1995;26:1178–82. 
Wendelboe AM, McCumber M, Hylek EM, et al. Global public awareness of venous thromboembolism. J Thromb Haemost 2015;13:1365–71.
Mathai SC, Ghofrani HA, Mayer E, et al. Quality of life in patients with chronic thromboembolic pulmonary hypertension. Eur Respir J 2016;48:526–37.
Sista AK, Miller LE, Kahn SR, Kline JA. Persistent right ventricular dysfunction, functional capacity limitation, exercise intolerance, and quality of life impairment following pulmonary embolism: Systematic review with meta-analysis. Vasc Med 2017;22:37–43. 
Cohen AT, Agnelli G, Anderson FA, et al. Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb Haemost 2007;98:756–64.
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After watching, you will be able to answer:

  • What are the biggest challenges with the current treatment of acute pulmonary embolism?
  • Do the current guidelines for acute Pulmonary Embolism provide an adequate tool for risk stratification?
  • Why is there a need for new treatments in acute Pulmonary Embolism?
  • What are the benefits of having a PE treatment pathway setup and PERT in your hospital?

Target Audience

  • Cardiologists
  • Interventional Cardiologists
  • Angiologists
  • Hematologists
  • Pulmonologists
  • Cardiovascular Surgeons
  • Intensive Care Medicine

More from this programme

Faculty Biographies

Felix Mahfoud

Felix Mahfoud

Associate Professor and Senior Physician

Professor Felix Mahfoud is an Associate Professor and senior physician of Internal Medicine and Cardiology at Saarland University Hospital, and Affiliate/Visiting Professor Harvard-MIT Biomedical Engineering, Institute of Medical Engineering and Science, Cambridge, US. Professor Mahfoud completed training in Cardiology and Interventional Cardiology at the Department for Internal Medicine III, Saarland University Hospital, Germany in 2014. Since 2017, he has served as Vice Chairman of the ‘Working Group on Interventional Hypertension Treatment’ for the European Society of Hypertension, and as a Committee Member of the 2018 Hypertension Guidelines.

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Nils Kucher

Nils Kucher

Professor of Angiology / Director University Clinic of Angiology

Prof Nils Kucher is a Professor of Angiology and Director University Clinic of Angiology at University Hospital Zürich, Zürich, CH.

He specialises in minimally invasive endovascular treatment of acute pulmonary embolism, acute deep vein thrombosis, and the post-thrombotic syndrome.

From 2016-2017 he was Chief Physician of Angiology at University Hospital Bern, where earlier he fulfilled the position of Staff Physician, Angiology & Cardiology, and Staff Physician, Interventional Cardiology.

Between 1999-2005 he undertook numerous fellowships both in Switzerland and the United States (Harvard Medical School). His research focuses on venous thromboembolism with more than 130 published articles.

 

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