TCT 2023 Late-Breaking Science Collection

Published: 09 January 2024

  • Views:

    Views Icon 250
  • Likes:

    Heart Icon 7
Average (ratings)
No ratings
Your rating


Stay up-to-date with our regular review series, View from the Thoraxcenter hosted by Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcenter, Erasmus MC, Rotterdam, NL). In this #TCT2023 edition they provide a short analysis of the most pertinent data from the late-breaking science presentations. 

Short, accessible Expert Interviews were conducted with investigators focusing on study design, key results and applicability of the latest data. 

About the episode

TCT 23 - We are joined by Dr Samir Kapadia (Cleveland Clinic, Cleveland, OH) to discuss the findings of the WATCH-TAVR Trial (NCT03173534).


WATCH-TAVR aimed to evaluate the safety and effectiveness of left atrial appendage occlusion with the WATCHMAN device to prevent stroke and bleeding in patients with atrial fibrillation (AF) who are undergoing transcatheter aortic valve replacement (TAVR). This is a prospective, multicenter, randomized trial, with 32 centers in the United States. 350 patients were enrolled, with 175 randomized to receive TAVR with medical therapy, and 175 to receive TAVR and WATCHMAN. 


Results showed that LAAO with the WATCHMAN 2.5 device at the time of TAVR is non-inferior to contemporary medical therapy for the composite endpoint of all-cause mortality, stroke and major bleeding at 2 years in patients with atrial fibrillation and severe asymptomatic aortic stenosis. In-hospital mortality was low (0.6%) in both groups with similar length of stay.


Interview Questions:

  1. What was the reasoning behind this trial?
  2. Could you tell us about the WATCHMAN device?
  3. What was the patient population and study design?
  4. What are the key findings?
  5. What are your take-home messages?
  6. What further study is still required, and what are the next steps?


Recorded remotely from Cleveland, 2023.

Editor: Jordan Rance
Video Specialist: Tom Green

Faculty Biographies

Samir R Kapadia

View full profile


You must be to comment. If you are not registered, you can register here.