Optimising Treatment of HF

Published: 21 April 2021

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Overview

Full programme

Part 5 of 5

PART 5 – How Will SGLT2 Inhibition Provide the Greatest Impact on HF-REF?

Martin R Cowie, Javed Butler, Shelley Zieroth, Giuseppe Rosano

Overview

Following recent changes to guidelines in light of the publication of Phase III data with SGLT2 inhibitors in patients with HFrEF, with and without type 2 diabetes, this programme brings together a leading faculty to best inform of the latest clinical evidence and real-world application for optimising treatment strategies in heart failure.

 

Prof Martin Cowie (Imperial College London, UK), moderates the proceedings, that comprises a number of insightful presentations and a panel discussion, with contributions from Prof Giuseppe Rosano (St George's Hospitals NHS Trust, London, UK), Dr Javed Butler (University of Mississippi, US), and Dr Shelley Zieroth (University of Manitoba, Canada).

Intended for healthcare professionals only. This IME programme is supported by an unrestricted educational grant from AstraZeneca, who has had no involvement in its organisation. Views and opinions expressed in the programme belong to the authors (faculty and delegates) and not necessarily to that of AstraZeneca.

Learning objectives

  • Recall recent changes to guidelines following the publication of Phase III data with SGLT2 inhibitors in patients with HFrEF, with and without type 2 diabetes
  • Describe the type and extent of clinical benefit observed when SGLT2 inhibitors are added to standard HF therapy in patients with HFrEF
  • Assimilate prevailing hypotheses and insights from key thought leaders on optimal therapeutic sequencing of the ‘five pillars’ of HF therapy
  • Apply newly gained knowledge on therapeutic sequencing to surrogate patient cases

Audience

  • Heart Failure Specialists
  • General Cardiologists
  • Nurses
  • Allied Health Professionals

More from this programme

Part 1

PART 1 – Introduction – Optimising Treatment of HF

Prof Martin Cowie introduces the topic, and reviews the learning objectives of the programme.

Part 2

PART 2 – A Review of Recent SGLT2 Inhibitor Data

Prof Giuseppe Rosano reviews recent SGLT2 trial data, including DAPA – HF, and Emperor Reduced.

Part 3

PART 3 – New HFrEF: When and How Should We Initiate an SGLT2 Inhibitor?

Dr Javed Butler presents a case, and considers available treatment strategies, and the optimal approach for HFrEF medications.

Part 4

PART 4 – Existing HF-REF: Augmenting the SOC

Dr Shelley Zieroth reviews how guideline-directed medical therapy for HFrEF has evolved, and notes that further changes are coming to practice.

Part 5

PART 5 – How Will SGLT2 Inhibition Provide the Greatest Impact on HF-REF?

Prof Cowie moderates a discussion with the faculty.

Faculty Biographies

Martin R Cowie

Martin R Cowie

Professor of Cardiology

Martin Cowie is Professor of Cardiology at King's College London, and Honorary Consultant Cardiologist at the Royal Brompton Hospital, London, UK. Prof Cowie chairs the Clinical Practice Committee of the British Cardiac Society and sits on the UK Department of Health’s Primary Care and Heart Failure Implementation Board. 

Prof Cowie's research interests focus on health technology assessment and delivery of efficient and effective care for patients with heart failure, with a focus on diagnostics, drugs, and devices. He has had a longstanding interest in evaluating remote monitoring and other digital technologies in heart failure.

Prof Cowie’s studies and reviews have been published in a variety of peer-reviewed journals, including The Lancet, European Heart Journal, British Medical Journal, Heart and International Journal of Cardiology. He is a member of the editorial boards of Heart, The British Journal of Diabetes and…

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Javed Butler

Javed Butler

Professor of Medicine

Dr Javed Butler is President, Baylor Scott and White Research Institute, Dallas, TX and Professor of Medicine, University of Mississippi, Jackson, MS, US. He is board certified in cardiovascular medicine and advanced heart failure and transplant medicine. His research interests focus on clinical trials in patients with heart failure. He has authored more than 900 peer-reviewed publications.

 

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Shelley Zieroth

Shelley Zieroth

University of Manitoba, Canada

Dr Shelley Zieroth is at SBH Heart Failure and Transplant Clinics and serves as Head of the Medical Heart Failure Program, WRHA Cardiac Sciences Program, and as Associate Professor of the Section of Cardiology at the University of Manitoba, Canada.

Dr Zieroth attended medical school at the University of Manitoba, where she went on to train in internal medicine and cardiology. She completed her postdoctoral clinical fellowship, specializing in advanced heart failure and cardiac transplant, at Toronto General Hospital. Dr Zieroth has lectured internationally on the subject of heart failure.

Dr Shelley Zieroth is an Editorial Board member of Cardiac Failure Review.

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Giuseppe Rosano

Giuseppe Rosano

Consultant Cardiologist and Professor of Cardiology (Hon)

Giuseppe Rosano is Consultant Cardiologist and Professor of Cardiology at St George’s, University of London where he is also the director of MSc Heart Failure.

After obtaining his MD in Medicine and Surgery at the La Sapienza University of Rome, Prof Rosano obtained his specialisation in cardiology from the same University before attaining his PhD in Medical Sciences from Imperial College London. His research interests focus on experimental and clinical pharmacology, heart failure, cardiac metabolism, diabetes and gender differences in cardiovascular diseases.

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