Device Management in HFpEF and HFmrEF: Insights From the REDUCE LAP-HF II Trial

Published: 24 January 2022

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HF with preserved ejection fraction (HFpEF) remains an unmet need, however new therapeutic strategies are emerging to improve quality of life and clinical outcomes. Although medical therapy is the cornerstone of treatment for individuals with EF ≥40%, there is a considerable need for approaches that extend these benefits to individuals who remain symptomatic following medical therapy. 


The following videos aim to educate physicians in the changing landscape of the device management of HFpEF.

This programme was supported by an unrestricted educational grant from Corvia Medical

Learning Objectives

  • Explain the clinical rationale behind an atrial shunt in HFpEF
  • Recall overall and pre-specified sub-group results from the REDUCE LAP-HF II trial
  • Describe the clinical features of likely responders and non-responders to an atrial shunt
  • Identify which HFpEF patients are likely to benefit from the use of an atrial shunt
  • Discuss the utility of cardiac interventions for the future treatment of HFpEF

Target Audience

  • Heart Failure Specialists
  • General Cardiologists

More from this programme

Part 1

Data Presentation

Dr Barry Borlaug presents a brief overview of the device and how it gains benefit in HFpEF.

Part 2

Roundtable Discussion

Prof Andrew Coats, Dr Barry Borlaug, Dr Sanjiv Shah and Prof Gerd Hasenfuß review the trial findings and discuss what the data means to the HF community and the wider cardiovascular community, alongside discussing why this data is important.

Faculty Biographies

Andrew JS Coats

Andrew JS Coats

Professor of Cardiology

Prof Andrew Coats is President of the Heart Failure Association and Professor of Cardiology, University of Warwick, UK. Head of Cardiology of Imperial College, London and Associate Medical Director and Director of Cardiology of the Royal Brompton and Harefield Hospitals, London. He is an Australian-British academic cardiologist as well as a successful fundraiser, university administrator and inventor. Prof Coats' main interest is heart failure.

Prof Coats is Editor-in-Chief of the Cardiac Failure Review editorial board. He has published over 20 patents and more than 650 full research papers and more than 100,000 career citations, with a personal H-index of 135. Andrew was elected to the Presidential Trio of the Heart Failure Association of the ESC in 2018 and will serve at its president 2020-2022.

From 2012 to 2017 he was Director of the Monash-Warwick Alliance, and before that…

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Barry Borlaug

Barry Borlaug

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Gerd Hasenfuß

Gerd Hasenfuß

Professor of Internal Medicine, Director of the Department of Cardiology and Pulmonology

Prof Gerd Hasenfuß is a Professor of Internal Medicine, Director of the Department of Cardiology and Pulmonology, Georg-August-Universität Göttingen; Chairman of the Heart Center and the Herzforschungszentrum Göttingen; Head of Internal Medicine, Clinic and Rehabilitation Center Lippoldsberg gGmbH.

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Sanjiv Shah

Sanjiv Shah


Dr Sanjiv Shah’s clinical expertise and research program are focused on HFpEF and in 2007, Dr Shah started the first dedicated HFpEF program in the world at Northwestern University. 

His research, which spans basic research in animal models, clinical physiologic studies, human clinical trials, and population-based epidemiology studies, has highlighted the heterogeneity and systemic nature of the HFpEF syndrome, and has improved the understanding of the risk factors, pathogenesis, and pathophysiology of HFpEF. 

He is an internationally recognised leading authority on HFpEF and routinely lectures at international cardiology meetings, continuing medical education meetings, and academic institutions.

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