The pivotal CIRCA-DOSE study was a randomized study that examined the AF burden in detail and changed how we conceptualise study endpoints when it published in Circulation back in 2019. Dr Dhiraj Gupta (Liverpool, UK) meets with the principal investigator of the study, Dr Jason Andrade (Vancouver, CA), who presents the data behind the original CIRCA-DOSE study and discusses the results from the recent secondary analysis examining the clinical definition of AF, which has recently been published in JAMA Open. They close by discussing how this research might influence clinical practice going forwards.