Cardiac Amyloidosis: Emerging Diagnostic and Treatment Approaches
Published: 08 February 2024
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Views:
13879
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Likes:
7
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Views:
13879
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Likes:
7
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7m 17s
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6m 56s
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5m 35s
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6m 7sPart 10 Echocardiography in Amyloidosis
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5m 35sPart 1 Cardiac and Non-Cardiac Features Philip Hawkins
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6m 16sPart 2 Cardiac Magnetic Resonance (CMR) in Amyloidosis Marianna Fontana
Overview
This micro-learning series focuses on the forefront of cardiac amyloidosis, a rapidly advancing field in healthcare. Providing a focussed and tailored update for key healthcare practitioners seeking to enhance their understanding of the latest developments in the diagnosis and treatment of cardiac amyloidosis and its consequences. Throughout this series, esteemed faculty delve into the intricate nature of amyloidosis, offering insights into the evolving management practices in cardiac amyloidosis. This educational journey navigates the nuances of diagnosing cardiac amyloidosis, emphasising the ability to distinguish between various types of the disease, addressing common pitfalls in assessment and underscoring the importance of a collaborative interdisciplinary approach.
Discover New Horizons in Amyloidosis (NHA)
Curious about the latest advancements in diagnosing and treating cardiac amyloidosis? New Horizons in Amyloidosis (NHA), a virtual conference which took place on February 28, 2024, is available to watch on-demand now.
Learning Objectives
- Understand the nature of amyloidosis and its effects on various organs, particularly the heart
- Distinguish between light-chain (AL) amyloidosis, wild type TTR amyloidosis and hereditary TTR amyloidosis in terms of their clinical manifestations and their different treatments
- Recognise the novel challenges of managing heart failure in cardiac amyloidosis, including both medical management and the role of devices
- Understand the critically important interaction between haematologists and cardiologists in the therapy of AL amyloidosis
- Develop an understanding of novel therapies currently in clinical trials of TTR and AL amyloidosis
- Identify their own roles and responsibilities in the management TTR and AL amyloidosis as part of a multidisciplinary team
Target Audience
- Cardiologists
- Imaging Specialists
- Electrophysiologists
- Primary care practitioners
- Haematologists
- Cardiac Nurse Practitioners
More from this programme
Part 1
An Overview of Amyloidosis:
In this video, Prof Philip Hawkins (University College London, London, UK), addresses some important key questions surrounding amyloidosis, a complex condition characterised by the abnormal accumulation of amyloid protein in tissues. He explores the nature of amyloid and the definition of amyloidosis, discussing its various forms and the significance of distinguishing among them. Join him as he unravels the importance of understanding the cardiac and non-cardiac manifestations of amyloidosis in clinical practice.
| 1 session | |
| Cardiac and Non-Cardiac Features | Watch now |
Part 2
Cardiac Magnetic Resonance (CMR) in Amyloidosis
In this video, Prof Marianna Fontana (Royal Free Hospital, London, UK) briefly discusses the role of cardiac magnetic resonance (CMR) in amyloidosis. She discusses techniques used for diagnosis, and measuring the cardiac amyloid burden, referring to European guidelines. She also discusses how to track treatment response.
Part 3
Light Chain (AL) Amyloidosis: The Importance of Early Diagnosis
In this video, Dr Paolo Milani (University of Pavia, Pavia, IT) discusses the importance of early diagnosis of AL Amyloidosis, the role of both the haematologist and cardiologist in diagnosis and treatment. Further, he highlights the importance of the wider multidisciplinary team and shares the approach adopted in Pavia.
Part 4
Hereditary TTR amyloidosis: Diagnosis and Treatment
In this video, Prof Julian Gillmore (University College London, London, UK) focuses on diagnosis and treatment principles for ATTR amyloidosis. He discusses the challenges faced in diagnosis and key differences between hereditary and non-hereditary TTR amyloidosis.
Part 5
How to Manage a Person With a Mutant TTR Gene and No Symptoms?
In this video, Dr Laura Obici (IRCCS Policlinico San Matteo Foundation, Pavia, IT) discusses the importance of early diagnosis and treatment for asymptomatic patients with a mutant TTR, highlighting recommendations and tests specific to both genotype and phenotype.
Part 6
Diagnosing Wild-Type TTR Amyloidosis (ATTRwt)
In this video, Dr Pablo Garcia-Pavia (Puerta de Hierro Majadahonda University Hospital, Madrid, ES) shares clinical clues which lead to diagnosis, appropriate screening and testing to diagnose the condition.
Part 7
Cardiac Amyloidosis: Non-pharmacologic Therapy (ICD Use)
In this video, Dr Carol Whelan (Royal Free Hospital, London, UK) discusses cardiac amyloidosis and non-pharmacologic therapy. She discusses atrial fibrilation, the role of ablation for atrial arrhythmias and the use of ICDS in cardiac amyloidosis, highlighting the need to further studies in many of these areas.
Part 8
Clinical Trials in Cardiac Amyloidosis: Targeting the Precursor Protein
In this video, Prof Julian Gillmore, (University College London, London, UK) presents some of the findings from recent and ongoing clinical trials in cardiac amyloidosis.
Part 9
PYP and DPD Imaging for the Diagnosis of Transthyretin Amyloidosis
Part 10
Echocardiography in Amyloidosis
| 1 session | |
| Echocardiography in Amyloidosis | Watch now |
About the episode
In this video, Dr Paolo Milani (University of Pavia, Pavia, IT) discusses the importance of early diagnosis of AL Amyloidosis, the role of both the haematologist and cardiologist in diagnosis and treatment. Further, he highlights the importance of the wider multidisciplinary team and shares the approach adopted in Pavia.
Faculty Biographies
Paolo Milani
Dr Paolo Milani works as a consultant in the Pavia Amyloidosis Research and Treatment Center at the Foundation “IRCCS Policlinico San Matteo” in Pavia, Italy. This is the national referral center for patients with amyloidosis in Italy, seeing over 200 newly-diagnosed patients with systemic AL amyloidosis every year. He is a member at large of the Board of Directors of the International Society of Amyloidosis.
Dr Milani currently works on all of the ongoing clinical trials at the Pavia Center and is the Principal Investigator of a clinical trial about the use of pomalidomide and daratumumab in relapsed/refractory patients with AL amyloidosis that is due to start. In addition, an important part of his research is the introduction and validation of surrogate endpoints (biomarkers-based) that could speed up enrolment and study termination, possibly also in drug registration trials. He is also involved in several laboratory projects with a specific focus on the…
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