David S Rosenbaum, MD, is Director and Chief of the Heart and Vascular Research Center at the MetroHealth Campus of Case Western Reserve University, Cleveland, Ohio. He is also Professor of Medicine, Biomedical Engineering, Physiology, and Biophysics at Case Western. He is a member of the American Association for the Advancement of Science, International Society for Heart Research, Central Society for Clinical Research, Cardiac Electrophysiology Society, and the Heart Rhythm Society. His primary research interests have focused on devising novel mechanistic understanding leading to improved methods for detection and treatment of cardiac arrhythmias. As a physician-scientist, he is best known for his work in high-resolution optical mapping with voltage sensitive dyes, translational approaches investigating mechanisms of electrical heterogeneity in the heart, and mechanisms of arrhythmias in heart failure. He has also been on the forefront in development of novel risk stratification tools such as microvolt T wave alternans, to identify patients at risk for sudden cardiac death.