Prof Patrono’s main research interest is in the study of platelet activation and inhibition in atherothrombosis and colorectal cancer. His research has characterised the human pharmacology of aspirin as an inhibitor of platelet cyclooxygenase (COX)-1, and provided the basis for the development of low-dose aspirin as an antithrombotic agent. During the past decade, Prof Patrono has contributed to characterising the human pharmacology of COX-2 inhibitors and evaluating their cardiovascular effects in different clinical settings.
His international experience includes working for 4 years in academic institutions in the USA (Mount Sinai School of Medicine, New York, and University of Pennsylvania School of Medicine, Philadelphia), and in the UK (Royal Postgraduate Medical School, London).
His current international collaborations include the Clinical Trials Unit of the UK Medical Research Council in London (Prof Ruth Langley), the Clinical Trials Service Unit of the University of Oxford (Prof Colin Baigent) and the Institute for Translational Medicine and Therapeutics of the University of Pennsylvania (Prof Garret FitzGerald).
He is an elected member of the Association of American Physicians, Royal College of Physicians, European Society of Cardiology, Academia Europaea and Accademia dei Lincei.
He has received the Alexander B Gutman award from the Mount Sinai School of Medicine, the Distinguished Award in Neuroscience from the Louisiana State University, the 1998 International Aspirin Award from Bayer AG, the 2007 John Vane Award from the William Harvey Research Institute of the University of London, the 2011 Outstanding Achievement Award of the Eicosanoid Research Foundation (shared with Garret FitzGerald), the 2013 Grand Prix Scientifique awarded by the Institut de France (shared with Garret FitzGerald) and the 2013 Lifetime Achievement Award of the European Association for Clinical Pharmacology and Therapeutics (shared with Sir Michael Rawlins).
He is a Section Editor of the Journal of the American College of Cardiology, and a member of the scientific advisory boards of the Dutch Heart Foundation, William Harvey Research Institute and International Aspirin Foundation.
Prof Patrono has published over 220 research articles with over 49,000 citations and an H-index of 95.