Unlocking the Challenges of Uncontrolled Hypertension

Published: 28 June 2024

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    Thomas Weber, Bryan Williams, Erika SW Jones
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The long term clinical implications of uncontrolled hypertension are well documented, but almost half of those with hypertension remain inadequately treated. In this symposium, our panel of three leading hypertension experts, Prof Thomas Weber (Klinikum Wels-Grieskirchen, Wels, AT), Prof Bryan Williams (University College London, London, UK) and Prof Erika Jones (University of Cape Town, Cape Town, SA), examine the current state of medical therapy, the barriers to optimal treatment and the underlying mechanisms driving uncontrolled hypertension, including the pivotal role played by aldosterone.


Presented, and recorded, at ESH 2024, in Berlin, DE. 

This symposium is supported by an unrestricted educational grant from AstraZeneca who had no involvement in the content.

Learning Objectives

  • Describe the long-term clinical impact of uncontrolled hypertension
  • Apply guideline-directed management to a patient case study
  • Evaluate the challenges and limitations of current management options for uncontrolled hypertension
  • Describe the role of aldosterone in uncontrolled hypertension

Target Audience

  • Hypertension (Htn) Specialists
  • Cardiologists / Internists
  • Nephrologists
  • GPs with an Interest in Htn

More from this programme

Part 1

Clinical Impact of Uncontrolled Htn and Case Presentation

In this first part, Prof Williams presents a patient case of a 56 year old male with a 20+ year history of hypertension. He presents the primary investigations and following this the panel discuss what is driving the uncontrolled hypertension, the clinical risk and current guideline-directed options. 

Part 2

Current Treatment Barriers and Limitations

Following presentation of the secondary investigations, the panel further discuss the underlying cause. Prof Weber then runs two audience polls to understand the significant cause of uncontrolled hypertension and barriers for currently available drugs to treat uncontrolled hypertension in your clinical practice. Following this, the panel discuss issues with the current Htn standard of care. 

Part 3

What Drives Uncontrolled Hypertension?

Prof Jones presents on other contributing factors for uncontrolled hypertension. She discusses adherence, the pathophysiology of hypertension, second line therapy and pheontyping patients. 

Part 4

Audience Q&A

The session closes with an engaging audience Q&A.

Faculty Biographies

Thomas  Weber

Thomas Weber

Associate Professor

Dr Thomas Weber is an Austrian cardiologist. He is Deputy Director of the Cardiology Department at the Klinikum Wels-Grieskirchen, in Wels, Austria. 

His clinical interests cover interventional cardiology, heart failure and hypertension while his scientific interests are pulsatile hemodynamics, arterial stiffness, vascular aging, 24-hour hemodynamics, heart failure, coronary artery disease, hypertension, aortic disease and renal denervation.

During his scientific career, he has authored 80 original articles, 61 review articles, 15 editorials, 14 international and national guidelines and consensus papers and 10 book chapters.

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Bryan  Williams

Bryan Williams

Chair of Medicine

Bryan Williams is Chair of Medicine at UCL and Chief Scientific and Medical Officer at the British Heart Foundation. He is also a Consultant Physician at University College London Hospitals (UCLH) where he was previously Director of the NIHR UCLH/UCL Biomedical Research Centre and Director of Research for UCLH (2014-2023).

Prof Williams research and specialist clinical practice is in the field of hypertension in which he is recognised as one of the world's leading authorities and is credited with driving changes in clinical practice globally. He has been a NHS Consultant Physician in front line care for 40 years. He has received numerous national and international awards and was the recipient of the Times Higher Education University award, for “Outstanding Innovation and Technology” 2011 and the Sleight Award (2014) by the European Society of Hypertension for his "outstanding contribution to research, education and clinical practice in the field of…

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Erika SW Jones

Erika SW Jones

Nephrology and Hypertension Specialist

Erika Jones is Associate Professor in the Division of Nephrology and Hypertension at the University of Cape Town and Groote Schuur Hospital in Cape Town, SA. 

Dr Jones interests are particularly in hypertension, having done her PhD in this area. One of the aspects of hypertension that she is studying currently and which is of major concern to nephrologists in Cape Town, is the rising incidence of young hypertensives with end stage renal disease in relation to methamphetamine usage.


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