Spotlight on EAS: Precision Lipid Management

Spotlight on EAS: Precision Lipid Management

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About the episode

Prof Erik Stroes provides an update on Lp(a) as an important cardiovascular risk factor, reviews current management strategies, and highlights ongoing clinical development of Lp(a)-lowering therapies, with a focus on the Phase 3 Lp(a) HORIZON trial.

Overview

This programme provides a focused spotlight on the latest developments and data presented at the European Atherosclerosis Society (EAS) Congress. Through a series of sessions, recorded at EAS and contributed by various faculty members, each offers concise analysis of late-breaking trial data, sub-analyses, and the clinical implications shaping contemporary lipid management.

 

Key Learning Objectives

  • Identify suitable patients for ApoC-III initiation using validated scoring parameters
  • Recall the most recent guidance for the use of ApoC-III inhibitor therapy
  • Discuss emerging clinical evidence of TG-lowering therapies across important trial sub-populations

Target Audience

  • Cardiologists
  • Lipidologists
  • Gastroenterologists
  • Endocrinologists
  • Other specialists associated with the management of familial chylomicronaemia syndrome (FCS)

More from this programme

Part 1

A Deep Dive Into the Data: Targeting ApoC-III Special Populations

The burden of hypertriglyceridemia (HTG) spans a broad and diverse patient population, from rare genetic disorders such as familial chylomicronaemia syndrome (FCS) to mixed hyperlipidaemia and familial dyslipidaemias. Current treatment strategies, including statins and fibrates, remain limited in their ability to adequately control triglyceride levels in many patients, highlighting the need for education around emerging therapeutic classes. ApoC-III–targeted therapies are demonstrating significant TG-lowering potential and are increasingly being evaluated across a wider range of patient populations, including those with FCS.


In this video, Dr Erin Michos (Johns Hopkins University School of Medicine, Baltimore, US) provides a deep dive into data presented at EAS 2026, targeting APOC-III in special populations.

 

This session is supported by an unrestricted educational grant from Arrowhead Pharmaceuticals.

Part 2

In Context: A Peer-To-Peer Discussion on ApoC-III in Special Populations and Other Emerging Data

The burden of hypertriglyceridemia (HTG) spans a broad and diverse patient population, from rare genetic disorders such as familial chylomicronaemia syndrome (FCS) to mixed hyperlipidaemia and familial dyslipidaemias. Current treatment strategies, including statins and fibrates, remain limited in their ability to adequately control triglyceride levels in many patients, highlighting the need for education around emerging therapeutic classes. ApoC-III–targeted therapies are demonstrating significant TG-lowering potential and are increasingly being evaluated across a wider range of patient populations, including those with FCS.

 

In this video, Dr Michos (Johns Hopkins University School of Medicine, Baltimore, US) is joined by Dr Christie Ballantyne (Baylor College of Medicine, Houston, US) for an in-depth discussion on real-world implications and clinical decision-making around applying emerging guidance and evidence in severe hypertriglyceridemia and FCS. They review evolving guidelines and what emerging data tells us about managing complex patient populations.

 

This session is supported by an unrestricted educational grant from Arrowhead Pharmaceuticals.

Faculty Biographies

Erik  Stroes

Erik Stroes

Chairman of the lipid clinic

Prof Erik Stroes is Chairman of the lipid clinic at Amsterdam University Medical Center (UMC) in the Netherlands. Prof Stroes is a vascular internist with a longstanding track of research in the field of lipidology, inflammation and atherosclerosis. His current research foci encompass the use of CT-angiography as a guide to tailored treatment regimens, pathophysiology of Lp(a) in atherogenesis and anti-inflammatory strategies in high cardiovascular risk patients. He has co-authored more than 540 peer-reviewed articles in the field of atherogenesis, (familial) hypercholesterolemia and cardiovascular treatment. He is Chair of the Dutch foundation aiming to optimise screening for familial hypercholesterolemia (LEEFH) and involved in several landmark trials in the cardiovascular arena.

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