SGLT-2 Inhibitors in Heart Failure: Putting the Evidence Into Practice

Published: 27 August 2021

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Following the release at ESC 2021 of updated guidelines for the diagnosis and treatment of acute and chronic heart failure, Prof Andrew Coats (Monash University, Australia and University of Warwick, UK) and Prof Giuseppe Rosano (St George's, University of London, UK) discuss the implications for treatment strategies.


This three-part series provides comprehensive update on some of the most important developments in HFrEF management including addressing key considerations of where SGLT-2 inhibitors fit into the new guidelines for HFrEF, when and how to initiate SGLT-2 inhibitors, and making evidence-based choices in the selection of SGLT-2 inhibitor.

This programme is supported by an unrestricted educational grant from AstraZeneca

Learning Objectives

  • Recall the latest recommendations and levels of evidence supporting the use of SGLT-2 inhibitors in heart failure (HF)
  • Consider the impact of delaying the adoption of all guideline-directed foundational therapies in existing HF
  • Make an evidence-based choice when selecting an SGLT-2 inhibitor in HF

Target Audience

  • Heart failure specialists
  • Cardiologists
  • Referring physicians
  • Allied health professionals

Series overview

Part 1

Where Do SGLT-2 Inhibitors Fit Into the New Guidelines for HFrEF?

Part 2

When and How to Initiate SGLT-2 Inhibitors in HFrEF

Part 3

Choosing an SGLT-2 Inhibitor – Making an Evidence-based Choice

Faculty Biographies

Andrew JS Coats

Andrew JS Coats

Director of the Monash Warwick Alliance and Academic Vice-President

Prof Andrew Coats is President of the Heart Failure Association and Professor of Cardiology, University of Warwick, UK. He is an Australian-British academic cardiologist and inventor. Prof Coats' main interest is heart failure.

From 2012 to 2017 he was Director of the Monash-Warwick Alliance, and before that served as Deputy Vice-Chancellor and Dean of Medicine of the University of Sydney.

He is an Australian-British academic cardiologist as well as a successful fundraiser, university administrator and inventor.

Prof Coats is Editor-in-Chief of the Cardiac Failure Review editorial board. 


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Giuseppe Rosano

Giuseppe Rosano

Consultant Cardiologist and Professor of Cardiology (Hon)

Giuseppe Rosano is Consultant Cardiologist and Professor of Cardiology at St George’s, University of London where he is also the director of MSc Heart Failure.

After obtaining his MD in Medicine and Surgery at the La Sapienza University of Rome, Prof Rosano obtained his specialisation in cardiology from the same University before attaining his PhD in Medical Sciences from Imperial College London. His research interests focus on experimental and clinical pharmacology, heart failure, cardiac metabolism, diabetes and gender differences in cardiovascular diseases.

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