SELUTION DeNovo: Latest Evidence and Expert Insights On DeNovo And ISR Lesions

  • Published:  13 January 2026
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    20m 37s
    Part 1 | Session 3 Discussion
    Peter O’Kane, Simon Eccleshall, Kalpa De Silva, Tom Johnson, Pitt Lim
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    Andrew Vanezis, Eltigani Abdelaal, Helen Routledge, Peter O’Kane, Jonathan Hinton, Simon Eccleshall
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    Andrew Vanezis, Eltigani Abdelaal, Helen Routledge, Peter O’Kane, Jonathan Hinton, Simon Eccleshall
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    Part 5 | Session 3 Bifurcations
    Andrew Vanezis, Eltigani Abdelaal, Helen Routledge, Peter O’Kane, Jonathan Hinton, Simon Eccleshall
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    Part 6 | Session 1 Acute Occlusions
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    17m 37s
    Part 6 | Session 2 Chronic Occlusions
    Karim Ratib, Andrew Ladwiniec, Elliot Smith, David Hildick-Smith, Jehangir Din
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    8m 35s
    Part 7 | Session 2 Left Main
    Peter O’Kane, Simon Eccleshall
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    Part 8 | Session 1 Discussion
    David Hildick-Smith, Nick Curzen, Peter O’Kane, Andrew Ladwiniec, Fraser Witherow

SELUTION DeNovo: Latest Evidence and Expert Insights On DeNovo And ISR Lesions

  • Published:  13 January 2026
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About the episode

Welcome to the World of Metal Free PCI

 

Faculty: Dr Peter O'Kane and Dr Simon Eccleshall

 

Panel: Dr Kalpa De Silva, Prof Tom Johnson and Dr Pitt Lim

 

Overview

This programme provides a practical, evidence-led review of drug-coated balloons in DeNovo coronary lesions. It examines the latest clinical data supporting DCB use and translates findings into decision-making for everyday PCI.

 

The content builds procedural confidence in DCB-based PCI, with emphasis on lesion preparation, intracoronary imaging techniques and optimal device delivery. Faculty also explore the main drivers of success, including drug formulation, balloon technology and procedural strategy.

 

Through expert-led discussion and real-world case studies, the programme addresses hybrid and stentless approaches for complex coronary anatomies. Participants will leave with clear, actionable insights to improve outcomes and standardise best practice.

This event is supported by Cordis

Learning Objectives

  • Analyse the latest clinical evidence supporting the use of drug-coated balloons in de novo coronary lesions
  • Enhance procedural proficiency in DCB-based PCI, with focus on lesion preparation, intracoronary imaging techniques and optimal device delivery
  • Identify key success drivers, including drug formulation, balloon technology and procedural strategy
  • Apply hybrid and stentless approaches in complex coronary anatomies using real-world case insights

Target Audience

  • Interventional cardiologists
  • General cardiologists with an interest in PCI
  • Cardiology fellows and trainees
  • Catheterisation laboratory clinicians involved in coronary interventions

More from this programme

Part 2

Statistical Analysis of SELUTION DeNovo

Part 3

Methods: Practical Tools - Lesion Preparation

Part 4

Methods: Practical Tools - Lesion Assessment

Part 5

Results: Clinical Cases that Met inclusion Criteria

Part 6

Results: Clinical Cases That Met Exclusion Criteria

Part 7

Evidence-based Strategies Recommended for Managing Challenging Coronary Lesions With DCB Where Stenting is Usually Considered?

Part 8

The Great Debate: The House That Believes That DCB PCI Should Become the Dominant Destination Therapy

Faculty Biographies

Peter O’Kane

Peter O’Kane

Consultant Interventional Cardiologist

Dr Peter O'Kane has been Editor-in-Chief of Interventional Cardiology: Reviews, Research, Resources (ICR3) since July 2021.

Dr Peter O’Kane was appointed as a consultant interventional cardiologist at Royal Bournemouth Hospital in July 2007 and has performed more than 7000 PCI cases. He has extensive experience with coronary physiology and intra-coronary imaging to guide intervention and the many tools and techniques to manage bifurcations, calcification and chronic occlusions.

Dr O'Kane has given his permission to be contacted here.

 

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Simon Eccleshall

Simon Eccleshall

Consultant Cardiologist

Dr Simon Eccleshall is a consultant cardiologist at Spire Norwich Hospital. Dr Eccleshall's cardiology practice and research are focused on the major health issue of coronary artery disease. 

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Kalpa De Silva

Kalpa De Silva

Consultant Interventional Cardiologist

Dr Kalpa De Silva has been a consultant interventional cardiologist at Guy's and St Thomas' NHS Foundation Trust since 2020. Previously he was a consultant interventional cardiologist at the Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust. He specialises in the management of coronary artery disease, looking after patients with chest pain, angina and those who have suffered heart attacks.

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Tom Johnson

Tom Johnson

Consultant Cardiologist

Prof Johnson is fully trained in percutaneous coronary intervention and all aspects of general cardiology including hypertension, cardiovascular risk assessment, valvular heart disease, heart failure and arrhythmia.

He qualified from St Mary's Hospital (Imperial College, London) in 1998 and prior to commencing specialist training in the South West he undertook a period of research studying novel treatment strategies to prevent re-narrowing of stented coronaries and bypass grafts, culminating in the award of an MD. Additionally, he spent one year as Interventional Fellow at the world renowned Greenlane Cardiovascular Unit in New Zealand.

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Pitt  Lim

Pitt Lim

Cardiologist

Dr Lim completed his MBBS at the University of Newcastle-upon-Tyne Medical School in 1990. He then undertook higher specialist training cardiovascular medicine at Ninewell University Hospital and Medical School, Dundee from 1994 to 2000. During this period he completed his MD in hypertensive heart disease and contributed to the development of the “Dundee Step Test” and 20 peer reviewed publications.

Dr Lim was appointed as consultant in cardiology at St George’s Hospital in 2005. Since taking up his post at St George’s he has introduced radial approach coronary interventions to the Trust and is currently the clinical lead for cardiac intervention.

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