SCAI 2025 - Outcomes from prosthesis-patient mismatch (PPM) in patients undergoing transcatheter aortic valve implantation (TAVI) show higher rates of severe predicted and measured PPM in female patients compared to male patients; however, PPM did not affect the five-year survival in women.

Dr Karim Al-Azizi (Baylor Scott & White The Heart Hospital, Plano, US) joins us to discuss the incidence and gender-based comparison outcomes from a large, multi-site, retrospective study investigating PPM in 3,000 patients who underwent native valve TAVI from 2012 to 2021. The primary outcome measure was all-cause mortality at 5 years, and the secondary outcome measures were PPM incidence, severity and residual transvalvular gradient.

Interview Questions:
1. What is the background behind the study, and why is it important to look at a gender-based comparison when investigating prosthesis-patient mismatch in TAVI patients?
2. What was the study design?
3. What are your key findings?
4. Did these findings highlight any gender-based considerations that should be made when treating patients with PPM?
5. What are your take-home messages for practice?
6. What further research is needed, and what are the next steps?

Recorded remotely from Plano, 2025.

Editors: Jordan Rance, Yazmin Sadik
Videographers: David Ben-Harosh

Support: This is an independent interview produced by Radcliffe Cardiology.