Optimal Management of Cardiac Implantable Electronic Device Infections

Published: 21 February 2023

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Although rare, the occurrence of a pacemaker or a defibrillator infection is an important complication which can and must be treated fast and effectively. On a weekly basis the story unfolds: how to best manage cardiac implantable electronic device (CIED) patients when their device becomes infected and gather insights from physicians with different specialties in an interactive setting.  


Click here to listen to the podcast versions.

This series is supported by

Learning Objectives:

  • What CIEDs are, what benefits they bring to a patient and potential complications
  • How to manage a CIED patient and which signs to look out for
  • Why antibiotics are ineffective against CIED infection
  • Which steps to take once a CIED infection is suspected
  • The procedure of lead extraction and its safety profile
  • The emotional journey for patients if referral is delayed
  • How to improve the patient care pathway
  • How one can help prevent CIED infection

Target Audience:

  • Physicians who manage patients with a CIED
  • Key departments include cardiology, infectiology, renal, emergency department and care of elderly

More from this programme

Part 1

Episode 1: What is a CIED?

Patients with a cardiac implantable electronic device (CIED), like a pacemaker or a defibrillator, can be of all ages and have different types of implants. You have probably encountered at least one of these in your everyday practice. In this episode, Angelo Auricchio and Archie Rao, both specialists in this area, will discuss types of CIEDs and what they do. They will highlight potential complications with focus on infection. CIED infection is frequently under-recognised and potentially life-threatening. The good news is, it is treatable.

Part 2

Episode 2: How to Recognise and Treat CIED Infection

Although rare, infection of a pacemaker or a defibrillator is an important complication which must and can be treated effectively. Cardiac electronic implantable device (CIED) infection is a Class I indication for extraction but recent data has demonstrated that less than 2 in 10 patients receive appropriate treatment. Prof Carina Blomström-Lundqvist, Swedish Professor of Cardiology, and Dr Archie Rao, British consultant cardiologist, are both passionate about this topic. Carina Blomström-Lundqvist is the lead author of the European CIED infection guidelines and Archie Rao has led a gap analysis into the knowledge of CIED infection and treatment. They explain how to recognise a patient at risk and what to do to provide best outcomes for your patient.

Part 3

Episode 3: Why Do Antibiotics Fail With CIED Infection?

Although rare, cardiac implantable electronic device (CIED) infections may occur at any timepoint in the lifecycle. It is important to remain alert and recognise signs early. Traditionally, antibiotics alone are used to treat infection. But for CIED infections, when treated with antibiotics only, the relapse rate varies between 50 and 100 percent. But why is that? Dan Atar, Editor-in-Chief of the scientific journal ‘Cardiology’, and infectiologist Stefan Hagel, not only challenge the traditional point of view but tear down the decades of belief which surround it. Why are antibiotics not doing the job? What are the consequences? What is the solution? Why are infections sometimes overlooked and what is the action to change that in your practice?

Part 4

Episode 4: Lead Extraction is the Solution to Treat CIED Infection

Infection of a cardiac electronic implantable device (CIED) is a rare, but serious complication. We now know that, because of the appearance of biofilm on implants, these infections cannot be treated by antibiotics alone. As such, Worldwide Cardiac Society guidelines recommend complete system removal of all hardware, including the leads, when an infection is present. Although the guidelines are clear, too many patients continue to not get the appropriate treatment. Why is that? Mauro Biffi and Carina Blomström-Lundqvist, both experts in the field of lead extraction, see a lot of patients fall through the cracks. They discuss why and what the consequences are of not extracting in time but also: what is the recommended care pathway to improve the outcomes.

Part 5

Episode 5: Procedure of Lead Extraction

Infection of a cardiac electronic implantable device (CIED) is a rare, but serious, complication. When this happens, the removal of the entire system, generator and leads, is the only correct way to treat the infection. What happens during a procedure with lead extraction? Brigitte Osswald, an expert in the field who has performed more than 3,500 lead extraction procedures, talks to Nicola Montano, a physician in internal medicine, about the fundamentals of the procedure and explains why and how this is lifesaving for her patients.

Part 6

Episode 6: Patients Stories of a CIED Infection

When the pacemaker or the defibrillator of a patient becomes infected, and if it's not immediately treated correctly, it can be a very emotional journey for the patient. Prof Biffi and Prof Ferreira have treated many CIED infection patients and often see cases where treatment was inappropriate or unnecessarily delayed. They share two touching patient stories with Prof Nicola Montano, physician in internal medicine. They discuss how these patients fell through the cracks of the diagnostic and therapeutic pathway and the devastating consequences for the patient.

Part 7

Episode 7: How to Improve the Care Pathway

An infection can have serious consequences for patients with a pacemaker or defibrillator when not treated appropriately. In this episode, Angelo Auricchio and Archie Rao explore which practical changes can be made to your clinical setting to improve these patients’ pathway.

Part 8

Episode 8: How Can CIED Infection Be Prevented?

Patients with a pacemaker or defibrillator have a risk of having a device-related infection. Discover in this episode which actions can be taken to reduce the risk for infection. From pre-procedure planning to post-operative care, Dan Atar, Editor-in-Chief of the scientific journal ‘Cardiology’, and Carina Blomström-Lundqvist, lead author on the international consensus document addressing this topic, will discuss preventative measures for CIED infection.”

Faculty Biographies

Mauro Biffi

Mauro Biffi

Clinical Cardiologist and Director of Electrophysiology

Dr Mauro Biffi is a Clinical Cardiologist and Director of Electrophysiology at Sant’Orsola-Malpighi Polyclinic, Bologna, IT. He is also a tutor at the Cardiology School of Bologna University and at several European training facilities.

His main areas of interest are arrhythmias and heart failure. Dr Biffi has participated in international clinical trials of pharmacological and non-pharmacological treatments (Dofetilide study of ventricular tachycardia suppression, B-LEFT study, ALSYNC trial, SOLVE CRT study, WRAP-IT trial, REVIVENT left ventricular reconstruction study, ADAPT-RESPONSE trial, ECG-BELT trial, ARTESIA study, ESC-EHRA EORP-AF registry and EV ICD Pivotal study).

He is focused on upstream prevention of complications associated to implantable cardiac devices therapy. Dr Biffi is the Clinical Coordinator of several multicenter studies (OPTIMIND Registry, ESSENTIAL Registry, DECODE Registry, CRT- Next randomized trial), and has co-authored more than…

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Carina Blomström-Lundqvist

Carina Blomström-Lundqvist

Professor of Cardiology

Dr Carina Blomström-Lundqvist is Professor of Cardiology at the Department of Cardiology, Institution of Medical Science, Uppsala, SE and Senior Consultant and Professor at the Department of Cardiology and Medical Science, Örebro University Hospital, Örebro, SE.

Dr Blomström-Lundqvist graduated in medicine in 1976, she went on to specialise in cardiology and internal medicine, and started research on haemodynamics and myocardial metabolism in patients with dilated cardiomyopathy. With the developments in electrophysiology she switched her research interest towards arrhythmias and after 3 years she defended her PhD thesis on the diagnostic and prognostic implications of arrhythmogenic right ventricular dysplasia in 1987 in Gothenburg, Sweden.

At Uppsala, Dr Blomström-Lundqvist has become research leader for the arrhythmia unit, mainly focusing on research related to atrial fibrillation (AF). In collaboration with the Department of Thoracic Surgery, procedures for…

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