Incorporating GDMT and PRO Endpoints for Personalised Heart Failure Management
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6m 31sPart 1 | Session 2 Early Initiation and Better Clinical Outcomes
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4m 59sPart 1 | Session 3 Achieving Early Uptake of GDMT
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6m 24sPart 2 | Session 1 Initiating SGLT-2 Inhibitors
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6m 49sPart 2 | Session 2 Evolving the Management Approach - AEs and MDTs
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6m 23sPart 3 | Session 1 QoL and Functional Measures of Treatment Success
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7m 18sPart 3 | Session 2 Clinical Evidence
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5m 25sPart 3 | Session 3 Practically Implementing PROMs
This series of peer-to-peer discussions examines the practicalities of personalising heart failure management in the context of recent changes to international clinical practice guidelines.
At this exciting juncture, we now have two SGLT-2 inhibitors that offer clinical benefit across the spectrum of ejection fraction, and an increasing body of real-world and registry-based data showing the clear benefit of early guideline directed medical therapy (GDMT) adoption. Further, there is a clear move towards the use of patient reported outcomes (PROs) in addition to clinical endpoints. But how can we start to incorporate these changes in current practice?
In this series, our specially selected faculty of experts consider how we can be using these recent developments to personalise our management approach to heart failure and why it matters for better long-term patient outcomes.
Key Learning Objectives
- Review current GDMT in HFrEF and HFpEF
- Describe the relationship between initiation of GDMT and HF outcomes
- Prescribe GDMT according to current international recommendations
- Recall the elements of the Kansas City Cardiomyopathy Questionnaire
- Describe the clinical studies that support the use of functional and QoL measures in practice
- Initiate QoL and functional improvement measures in routine practice
- Initiate SGLT-2 inhibitors in patients presenting with De novo HF and in patients already on other GDMT
- Adopt shared decision making with HF patients
Target Audience
- Cardiologists
- Heart Failure Specialists
- Primary Care Physicians
- Nurses
- Pharmacists
- Other allied HCPs
More from this programme
Part 1
Optimising Clinical Success With Foundational Heart Failure Treatment
Prof Coats (Heart Research Institute, Sydney, AU) and Dr Kosiborod (Saint Luke’s Mid America Heart Institute, Kansas City, US) start by summarising current foundational heart failure therapy and how guidance has recently changed across the spectrum of ejection fraction. Following this, they explore recent evidence supporting initiation of GDMT and offer practical advice for the implementation of treatment, including possible solutions to the early uptake of GDMT.
Part 2
Personalising Your Approach to Heart Failure Treatment
Prof Rosano (St George’s University Hospital, University of London, UK) and Dr Bozkurt (Baylor College of Medicine, Texas, US) begin by discussing how one should be initiating SGLT-2 inhibitors across the continuum of ejection fraction and across patients who are treatment naïve versus those already on existing HF medications. Referring to the recent clinical practice guidelines, Dr Bozkurt advocates the early initiation of SGLT-2 inhibitors and goes on to provide practical advice on the monitoring and continual use of these agents for better long-term outcomes.
Part 3
Adopting Patient Reported Outcomes in Heart Failure Management
Dr Kosiborod (Saint Luke’s Mid America Heart Institute, US) and Dr Zieroth (St Boniface Hospital, Winnipeg, CA) discuss the adoption of PROs in clinical management of patients with HF. They start by discussing quality of life (QoL) measures and close by looking at practical implementation of tools, such as the Kansas City Cardiomyopathy Questionnaire (KCCQ), in clinical practice and HF management.
Faculty Biographies
Andrew JS Coats
Professor of Cardiology and Scientific Director
Professor Andrew Coats was born in Melbourne, Australia. He studied at St Catherine’s College, Oxford, where he earned a B.A. in Physiological Sciences with First-Class Honours, and then completed his medical degree (M.B. B.Chir.) at Clare College, Cambridge. He later obtained higher doctorates (D.M. and D.Sc.) in recognition of his substantial contributions to cardiovascular medicine, and he also completed an MBA at the London Business School. Professor Coats serves as Editor-in-Chief of the Cardiac Failure Review journal.
Career Overview
Andrew Coats is an internationally renowned academic cardiologist, inventor, and university leader with a career spanning more than three decades. He is currently the Scientific Director and CEO of the Heart Research Institute in Sydney, Australia. He also serves as Dean of the Royal Australasian College of Physicians, Affiliate Professor at Deakin University, and Emeritus Professor of Medicine at Monash University.
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Mikhail Kosiborod
Professor of Medicine
Dr Mikhail Kosiborod is a cardiologist based in the United States, where he serves as Senior Vice President, Late-stage Development, CVRM at AstraZeneca and Professor of Medicine at the University of Missouri…
Biykem Bozkurt
Dr Biykem Bozkurt is the Immediate Past President of the Heart Failure Society of America.
Dr Bozkurt is a Professor of Medicine, an advanced heart failure and cardiac transplantation specialist, Medical Care Line Executive (Medicine Department Chair) at the DeBakey VA Medical Center; W.A. “Tex” and Deborah Moncrief, Jr., Chair; Mary and Gordon Cain Chair; Vice-Chair of Department of Medicine; Director of the Winters Center for Heart Failure and Associate Director of Cardiovascular Research Institute at Baylor College of Medicine.
Giuseppe Rosano
Consultant Cardiologist and Professor of Cardiology (Hon)
Giuseppe Rosano was born and raised in Vibo Valentia, Italy, where he developed an early interest in medicine and cardiovascular science. While detailed information about his family and early childhood is not widely published, his Italian background and international academic career reflect strong cultural roots combined with global engagement in cardiovascular medicine.
Academic History
Professor Rosano obtained his Medical Degree in Medicine and Surgery with full honours from La Sapienza University of Rome in 1988. He subsequently completed his specialisation in Cardiology in 1992. Following his clinical training, he pursued advanced academic and research qualifications in the United Kingdom, earning both an MSc and a PhD in Medical Sciences from Imperial College London. His postgraduate research focused on cardiovascular physiology and pharmacology, forming the foundation of his future work in heart failure and cardiac metabolism.
Shelley Zieroth
Director, Heart Failure and Heart Transplant Clinics
Dr Shelley Zieroth is Professor at the College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, as well as Director of the Heart Failure and Heart Transplant Clinics at St Boniface Hospital in Winnipeg, Canada. She is also Head of the Medical Heart Failure Program for Cardiac Sciences Manitoba.
She is involved in several heart failure clinical trials as a PI, National Lead or Executive Committee member. She is the Past President of the Canadian Heart Failure Society and Co-Chair of the Canadian Cardiovascular Society Heart Failure Guidelines. She is co-chair of Canada’s largest annual heart failure meeting, HF Update, and Past President of the Federation of Medical Women of Canada.
Dr Shelley Zieroth is an Editorial Board member of Cardiac Failure Review.