EuroPCR 25 - Real-world registry findings show transcatheter edge-to-edge repair (TEER) is associated with improved prognosis in patients with atrial functional mitral regurgitation (AFMR).

We are joined by Dr Tomohiro Kaneko (Juntendo University Graduate School of Medicine, Tokyo, JP) to discuss outcomes from a retrospective cohort study analysing data from two large-scale Japanese registries, the REVEAL-AFMR and OCEAN-Mitral registries, to investigate the impact of TEER on prognosis in patients with AFMR. 507 patients with AFMR were extracted from the OCEAN-Mitral registry and 718 patients with moderate-to-severe AFMR were identified from the REVEAL-AFMR registry. The final analysis compared 441 patients in the TEER group and 640 patients in the medically treated group.

Findings showed patients receiving TEER had a significantly lower risk of heart failure hospitalisation and all-cause mortality compared to the medication group, this was most prominently observed in patients with well controlled mitral regurgitation after the procedure.

Interview Questions:
1. What are the current unmet needs in AFMR management, and what is the reasoning behind the registry-based study?
2. What was the study design and patient population?
3. What were the key findings, and were there any unexpected results?
4. What are the next steps?

Recorded at EuroPCR 2025, Paris, France.

Editors: Yazmin Sadik, Jordan Rance
Videographer: Dan Brent, Oliver Miles

Support: This is an independent interview produced by Radcliffe Cardiology.