EuroPCR 25 - Post-hoc anlysis outcomes from under-expansion of the ACURATE neo2 valve in severe aortic stenosis (AS) patients show under-expansion was associated with higher rates of death, stroke or rehospitalisation.

We are joined by Dr Raj Makkar (Cedars-Sinai Heart Institute, Los Angeles, US) to discuss findings from the post-hoc analysis of the ACURATE IDE study (NCT03735667; Boston Scientific Corporation), investigating valve under-expansion of the ACURATE neo2 Aortic Valve System using a core-laboratory analysis in patients with severe symptomatic AS undergoing transcatheter aortic valve replacement. The primary endpoint was death, stroke or rehospitalisation.

Findings showed that under-expansion of the ACURATE neo2 valve caused higher rates of the primary endpoint, and patients with a lower Doppler velocity index were more likely to experience under-expansion. A trend towards higher leakage rates in under-expanded valves was also observed.

Interview Questions:
1. What is the importance behind the post-hoc analysis?
2. Could you tell us more about the ACURATE neo2 Aortic Valve System?
3. What was the study design and patient population?
4. What were the key findings?
5. How should these findings impact clinical practice?
6. What further research is needed in this area?

Recorded at EuroPCR 2025, Paris, France.

Editors: Yazmin Sadik, Jordan Rance
Videographer: Dan Brent, Mike Knight

Support: This is an independent interview produced by Radcliffe Cardiology.