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12m 36sPart 3 | Session 3 BETAMI-DANBLOCK: Beta-blockers after MI
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14m 3sPart 3 | Session 4 ESC 25 Guidelines Discussion: Management of Dyslipidaemias
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14m 30sPart 3 | Session 5 2025 ESC/EACTS Guidelines for the Management of Valvular Heart Disease
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27m 8s
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4m 15sPart 4 | Session 1 TRISCEND II Trial: TTVR Outcomes by Baseline TR Severity
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3m 52sPart 4 | Session 2 The VICTOR & VICTORIA Pooled Analysis
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5m 10s
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7m 42sPart 4 | Session 4 ESVM Guidelines on Interventional Treatment of Venous Thromboembolism
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7m 12s
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6m 54sPart 4 | Session 6 STEEER-AF Cluster Randomised Trial by the ESC and EHRA
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10m 5sPart 4 | Session 7 NEWTON-CABG CardioLink-5: Evolocumab and Saphenous Vein Graft Patency
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7m 43s
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6m 35sPart 4 | Session 9 SWEDEPAD 1 and 2: Drug-Coated Devices in Peripheral Arterial Disease
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5m 6sPart 4 | Session 10 Lifetime Benefits of Combination Therapy in HFpEF
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3m 53sPart 4 | Session 11 REBOOT-CNIC: Beta-blockers After Infarction with LVEF Greater Than 40%
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4m 31sPart 4 | Session 12 ODYSSEY-HCM: Mavacamten in Non-obstructive Hypertrophic Cardiomyopathy
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6m 37sPart 4 | Session 13 Pooled MACE Data for Obicetrapib
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8m 9sPart 4 | Session 14 STRIDE: Outcomes by Sex
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4m 27sPart 4 | Session 15 The SEMA-VR CardioLink-15 Trial
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7m 20sPart 4 | Session 16 The CARUSO Trial: Carotid Plaques Stabilisation and Regression with Evolocumab
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3m 38sPart 4 | Session 17 EMORI-HCM: Electromagnetically Optimised Right Ventricular Pacing for oHCM
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47m 54sPart 1 | Session 1 View from the Thoraxcenter: ESC 25 Late-breaking Science Wrap-Up
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36m 33sPart 1 | Session 2 View from the Thoraxcenter: What's Hot at ESC 25?
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11m 8sPart 2 | Session 1 Day 4 Wrap-Up with Dr Alasnag and Dr Al-Shaibi
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19m 8sPart 2 | Session 2 Day 3 Wrap-Up with Dr Alasnag and Dr Al-Shaibi
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13m 11sPart 2 | Session 3 Day 2 Wrap-Up with Dr Alasnag and Dr Al-Shaibi
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14m 10sPart 2 | Session 4 Day 1 Wrap-Up with Dr Alasnag and Dr Al-Shaibi
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13m 4sPart 3 | Session 1 VICTOR: Vericiguat in Heart Failure
ESC Congress 2025 - Digitoxin reduced the risk of all-cause mortality and hospitalisation in patients with worsening heart failure.
Dr Harriette Van Spall (McMaster University, CA) sits down with Prof Udo Bavendiek to explore the DIGIT-HF trial, investigating whether digitoxin can improve outcomes in patients with advanced chronic heart failure and reduced ejection fraction.
This landmark study randomizes 1212 patients with advanced chronic HFrEF across multiple centers, comparing digitoxin therapy (targeting serum concentrations of 8-18 ng/mL) against placebo, both administered alongside guideline-directed standard of care treatment. The trial focuses on patients with NYHA functional class III-IV symptoms and LVEF ≤40%, or those with NYHA class II and LVEF ≤30%.
Findings showed that digitoxin significantly reduced a composite of all-cause death and hospitalisation in patients with worsening heart failure.
Recorded on-site at ESC Congress 2025, Madrid.
Editors: Jordan Rance, Yazmin Sadik.
Video Specialists: Dan Brent, Tom Green, Mike Knight, Oliver Miles, David Ben-Harosh.
Support: This is an independent interview produced by Radcliffe Cardiology.
Dive into our coverage of ESC Congress 2025 for groundbreaking trial results and discussions with expert faculty.
- Watch our View From the Thoraxcenter series for practice-focused reviews of the most anticipated trials from interventional experts, Prof Nicolas Van Mieghem and Dr Joost Daemen.
- Watch our Wrap-Up series led by Dr Mirvat Alasnag summarising the key take-aways from each day of the congress.
- For clinical trial data from principal investigators, keep up with Dr Harriette Van Spall's Late-Breaker Discussion series.
- Our concise, accessible Expert Interviews will focus on the current data and it's impact on clinical practice.
- Don't miss the Highlights series to stay ahead of the curve in each field.
- In the Journal Discussions series, authors of ECR Journal explore their special focuses in depth.
More from this programme
Part 1
View from the Thoraxcenter: What's Hot at ESC 25?
Part 2
Daily Wrap Ups with Dr Mirvat Alasnag
Part 3
Hot-line Discussions with Dr Harriette Van Spall
Part 4
Expert Interviews
Part 5
Highlights
Faculty Biographies
Harriette Van Spall
Associate Professor of Medicine, Director of E-Health and Virtual Care
Dr Harriette Van Spall is an internationally-known cardiologist, research methodologist, and senior scientist. Trained at the University of Toronto and Harvard University, she has expertise in clinical trial design and execution. Her investigator-initiated research is well funded and has been recognised formally with the American Heart Association's Nanette Wenger Research Goes Red award and the Canadian Institutes of Health Research Mid-Career Lectureship award.
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