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6m 37sPart 4 | Session 13 Pooled MACE Data for Obicetrapib
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8m 9sPart 4 | Session 14 STRIDE: Outcomes by Sex
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4m 27sPart 4 | Session 15 The SEMA-VR CardioLink-15 Trial
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7m 20sPart 4 | Session 16 The CARUSO Trial: Carotid Plaques Stabilisation and Regression with Evolocumab
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3m 38sPart 4 | Session 17 EMORI-HCM: Electromagnetically Optimised Right Ventricular Pacing for oHCM
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47m 54sPart 1 | Session 1 View from the Thoraxcenter: ESC 25 Late-breaking Science Wrap-Up
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36m 33sPart 1 | Session 2 View from the Thoraxcenter: What's Hot at ESC 25?
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11m 8sPart 2 | Session 1 Day 4 Wrap-Up with Dr Alasnag and Dr Al-Shaibi
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19m 8sPart 2 | Session 2 Day 3 Wrap-Up with Dr Alasnag and Dr Al-Shaibi
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13m 11sPart 2 | Session 3 Day 2 Wrap-Up with Dr Alasnag and Dr Al-Shaibi
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14m 10sPart 2 | Session 4 Day 1 Wrap-Up with Dr Alasnag and Dr Al-Shaibi
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13m 4sPart 3 | Session 1 VICTOR: Vericiguat in Heart Failure
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12m 24sPart 3 | Session 2 DIGIT-HF: Cardiac Glycosides in HFrEF
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12m 36sPart 3 | Session 3 BETAMI-DANBLOCK: Beta-blockers after MI
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14m 3sPart 3 | Session 4 ESC 25 Guidelines Discussion: Management of Dyslipidaemias
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14m 30sPart 3 | Session 5 2025 ESC/EACTS Guidelines for the Management of Valvular Heart Disease
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27m 8s
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4m 15sPart 4 | Session 1 TRISCEND II Trial: TTVR Outcomes by Baseline TR Severity
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3m 52sPart 4 | Session 2 The VICTOR & VICTORIA Pooled Analysis
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5m 10s
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7m 42sPart 4 | Session 4 ESVM Guidelines on Interventional Treatment of Venous Thromboembolism
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7m 12s
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6m 54sPart 4 | Session 6 STEEER-AF Cluster Randomised Trial by the ESC and EHRA
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10m 5sPart 4 | Session 7 NEWTON-CABG CardioLink-5: Evolocumab and Saphenous Vein Graft Patency
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7m 43s
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6m 35sPart 4 | Session 9 SWEDEPAD 1 and 2: Drug-Coated Devices in Peripheral Arterial Disease
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5m 6sPart 4 | Session 10 Lifetime Benefits of Combination Therapy in HFpEF
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3m 53sPart 4 | Session 11 REBOOT-CNIC: Beta-blockers After Infarction with LVEF Greater Than 40%
ESC Congress 2025 - ODYSSEY-HCM finds no improvements in patients with non-obstructive cardiomyopathy when treated with mavacamten.
Dr Milind Desai (Cleveland Clinic, US) joins us to discuss findings from the ODYSSEY-HCM trial, evaluating the safety, tolerability, and efficacy of mavacamten in patients with symptomatic non-obstructive hypertrophic cardiomyopathy.
The ODYSSEY-HCM study was a randomised, double-blind, placebo-controlled trial examining mavacamten compared with placebo in participants with symptomatic non-obstructive hypertrophic cardiomyopathy (nHCM). This parallel assignment study evaluated specified doses of mavacamten against placebo over 48 weeks, with primary outcome measures including change from baseline in Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-23 CSS) and peak oxygen consumption (pVO2) at Week 48.
Findings showed no significant differences in the primary endpoint with mavacamten compared to placebo at 48 weeks.
Interview Questions:
- What was the rationale behind ODYSSEY-HCM?
- What was the study design and patient population?
- What were your key findings?
- How might these results change the treatment landscape for patients with non-obstructive hypertrophic cardiomyopathy?
- What are the next steps for mavacamten development in this patient population based on these ODYSSEY-HCM results?
Recorded on-site at ESC Congress 2025, Madrid.
Editors: Jordan Rance, Yazmin Sadik.
Videographers: Mike Knight, Dan Brent, Oliver Miles, Tom Green, David-Ben-Harosh.
Support: This is an independent interview produced by Radcliffe Cardiology.
Dive into our coverage of ESC Congress 2025 for groundbreaking trial results and discussions with expert faculty.
- Watch our View From the Thoraxcenter series for practice-focused reviews of the most anticipated trials from interventional experts, Prof Nicolas Van Mieghem and Dr Joost Daemen.
- Watch our Wrap-Up series led by Dr Mirvat Alasnag summarising the key take-aways from each day of the congress.
- For clinical trial data from principal investigators, keep up with Dr Harriette Van Spall's Late-Breaker Discussion series.
- Our concise, accessible Expert Interviews will focus on the current data and it's impact on clinical practice.
- Don't miss the Highlights series to stay ahead of the curve in each field.
- In the Journal Discussions series, authors of ECR Journal explore their special focuses in depth.
More from this programme
Part 1
View from the Thoraxcenter: What's Hot at ESC 25?
Part 2
Daily Wrap Ups with Dr Mirvat Alasnag
Part 3
Hot-line Discussions with Dr Harriette Van Spall
Part 4
Expert Interviews
Part 5
Highlights
Faculty Biographies
Milind Y Desai
Professor of Medicine
Dr Milind Desai works as the Director of the Hypertrophic Cardiomyopathy Center at the Heart, Vascular and Thoracic Institute at Cleveland Clinic. He also serves as a Professor of Medicine at the Cleveland Clinic Lerner College of Medicine.
Alongside holding the Haslam Family Endowed Chair in Cardiovascular Medicine, Dr Desai has dual appointments in the Departments of Cardiovascular Medicine, within the Section of Cardiovascular Imaging, and Radiology. He is also a visiting professor at the University of Oxford, UK.
Dr Desai's clinical interests are heart valve disease, hypertrophic cardiomyopathy, aortic disorders, complex coronary artery disease, pericardial disease, and radiation heart disease. Dr Desai has a special interest in multimodality cardiovascular imaging, including echocardiogram, computed tomography (CT) scan and magnetic resonance imaging (MRI).
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