Controversies Regarding Subclinical Leaflet Thrombosis After TAVR

Published: 25 February 2021

  • Views:

    Views Icon 1184
  • Likes:

    Heart Icon 7
  • episode_image
    Now Playing
    Part 3 | Session 2 of 3
    Renate B Schnabel
    Up Next
  • episode_image
    11m 57s
    Part 3 | Session 3 Panel discussion & Audience Questions
    Jolanta Siller-Matula, Mamas A Mamas, Poonam Velagapudi, Kimberly Atianzar, Renate B Schnabel
  • episode_image
    10m 22s
    Part 2 | Session 1 PRO Mamas A Mamas
  • episode_image
    10m 45s
    Part 2 | Session 2 CONTRA Poonam Velagapudi
  • episode_image
    11m 47s
    Part 3 | Session 1 PRO Kimberly Atianzar
Average (ratings)
No ratings
Your rating


A substantial number of patients develop a subclinical leaflet thrombosis (SLT) after transcatheter aortic valve replacement (TAVR).

The thrombus forms on the leaflets, which can lead to valve dysfunction and possibly to early valve degeneration. Multidetector computed tomography is the most sensitive imaging technique at detecting SLT.

Patients on antiplatelet drugs are at higher risk to develop SLT as compared to those on anticoagulants. During the live debate, the experts in the field will discuss controversies concerning SLT, including the routine use of oral anticoagulants and CT exams after TAVR.

Learning Objectives

  • To learn about the natural history, incidence and clinical implications of SLT
  • To learn about the mechanisms that may lead to SLT
  • To understand the diagnostic criteria SLT
  • To discuss the prevention and treatment options for SLT


  • Interventional cardiologists with focus on TAVR procedures
  • Cardiac Imaging specialists (Echocardiography, Computer Tomography)
  • General cardiologists
  • Specialists interested in management of antithrombotic therapies after TAVR

More from this programme

Part 1

Subclinical leaflet thrombosis after TAVR: Numbers and facts

Part 2

Debate: Patients should receive routine CT screening after TAVR to exclude subclinical valve thrombosis

Part 3

Debate: Patients should be routinely discharged on oral anticoagulants for prevention of subclinical valve thrombosis after TAVR

Faculty Biographies

Renate Schnabel

Renate Schnabel

Consultant in Cardiology

Renate Schnabel is a consultant in cardiology at University Heart Centre Hamburg, Germany. She graduated from medical school in Mainz, Germany in 2002. After a research fellowship at the Framingham Heart Study, Boston University, she moved to Hamburg. She works with clinical and population cohorts and leads national and EU-funded international consortia. She is PI of the German Centre for Cardiovascular Research. Her research interest is in digital cardiology, atrial fibrillation and heart failure, and omics for cardiovascular risk assessment. Very active within professional organizations, she is member on councils of the European Society of Cardiology, American Heart Association and the German Cardiac Society.

View full profile