Explore the challenges and outcomes of TAVI in bicuspid aortic stenosis with Prof Ole De Backer (Rigshospitalet, Copenhagen, Denmark).

This presentation, part of a comprehensive two-part series on complex cases in interventional cardiology, examines the unique anatomical considerations and clinical evidence when treating bicuspid valve disease with transcatheter techniques.

Prof De Backer addresses the critical question of TAVI versus surgery in bicuspid patients, highlighting the distinct anatomical challenges including enlarged annular dimensions, excessive calcification, and complex root geometry. Drawing from the NOTION-2 trial and EVOLUT bicuspid registry data, the presentation reveals important insights about procedural outcomes and long-term durability. Key findings demonstrate the importance of bicuspid phenotype classification, with particular emphasis on valve under-expansion and its impact on leaflet thrombosis rates.

The presentation concludes with practical guidance for patient selection and procedural planning, emphasizing that while TAVI shows promise in carefully selected bicuspid cases, meticulous case-by-case evaluation remains essential for optimal outcomes in this challenging patient population.

Stay tuned for more content from the Complex Cases track of Women As One’s CLIMB® 2025 Skills Training Program.

About Women As One

Women As One is a global organization dedicated to empowering women in cardiology. They offer a variety of resources and programs, including the CLIMB Skills Training Program and the Women As One Talent Directory, a global community of women in cardiology.

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