Discover the rapidly evolving therapeutic options transforming outcomes for cardiac amyloidosis patients with Dr Sarah Cuddy.

This comprehensive presentation, part of the Cardiomyopathies track, explores the dramatic advances in both TTR and AL amyloidosis treatment over the past decade. Dr Cuddy examines how modern therapeutic approaches have fundamentally shifted survival curves, particularly highlighting the revolutionary impact of daratumumab-based regimens in AL amyloidosis management.

The presentation covers cutting-edge developments including the promising phase III data for NNI-006 (now LXN-2200), an antibody therapy showing up to 20% reduction in extracellular volume within the myocardium. Dr Cuddy also discusses emerging therapies such as BCMA BiTE therapy, which has shown phenomenal results in recent studies.

Beyond disease-specific treatments, the discussion provides practical guidance on supportive care strategies, including the evolving evidence for SGLT-2 inhibitors and mineralocorticoid receptor antagonists. Dr Cuddy addresses the nuanced approach to traditional heart failure medications in amyloidosis patients, highlighting when to use and when to avoid specific drug classes based on the unique pathophysiology of infiltrative cardiomyopathy.

The presentation emphasizes the critical importance of rapid diagnosis and treatment initiation, particularly in AL amyloidosis where early intervention dramatically improves outcomes. Key insights focus on achieving rapid and complete light chain knockdown and the superior tolerability of newer regimens compared to historical high-dose chemotherapy approaches.

Stay tuned for more content from the Cardiomyopathies track of Women As One's CLIMB® 2025 Skills Training Program.

About Women As One

Women As One is a global organization dedicated to empowering women in cardiology. They offer a variety of resources and programs, including the CLIMB® 2025 Skills Training Program and the Women As One Talent Directory, a global community of women in cardiology.

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