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4m 6sPart 1 | Session 2 STEMI-DTU – Door-to-Unload Strategy in STEMI
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5m 31sPart 1 | Session 3 CHIP-BCIS3 – Mechanical Support in High-Risk PCI
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4m 28sPart 1 | Session 4 CHAMPION-AF – LAAO vs NOACs in Atrial Fibrillation
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3m 10sPart 1 | Session 5 SPIRIT-HF – Interventional Strategies in Heart Failure
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3m 21sPart 1 | Session 6 ALL-RISE & FAST III – Renal Denervation and Blood Pressure Control
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2m 21sPart 1 | Session 7 OPTIMAL – Imaging-Guided PCI
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3m 2sPart 1 | Session 8 DKCRUSH VIII – Modern Bifurcation Techniques
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3m 15sPart 1 | Session 9 ORBITA-CTO – Sham-Controlled CTO PCI
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4m 38sPart 1 | Session 10 PRO-TAVI – Optimising TAVI Pathways
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3m 57sPart 1 | Session 11 PROTECT H2H – Head-to-Head Embolic Protection
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4m 55sPart 1 | Session 12 TRILUMINATE, TRI-FR & TRISCEND II – Transcatheter Tricuspid Interventions
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4m 37sPart 1 | Session 13 SURVIV – Cardiogenic Shock and Very High-Risk Patients
Prof Nicolas Van Mieghem & Dr Azeem Latib unpack HI‑PEITHO, the pivotal trial comparing ultrasound‑facilitated, catheter‑directed thrombolysis using the EKOS system plus anticoagulation with anticoagulation alone in intermediate–high‑risk pulmonary embolism. They highlight the significant reduction in early clinical deterioration, the reassuring bleeding profile and the very selective nature of the enrolled population. The discussion focuses on where ultrasound‑facilitated thrombolysis sits alongside large‑bore thrombectomy and systemic lysis, and which PE patients in your service might genuinely benefit from this approach.
ACC.26 late‑breaking trials, explained in one place.
In this focused highlights series, Prof Nicolas Van Mieghem (Erasmus University, Rotterdam) and Dr Azeem Latib (Montefiore Medical Center, New York) break down the key interventional trials from ACC.26 and turn them into clear, practical takeaways for daily practice across Europe and the US.
From HI‑PEITHO, STEMI‑DTU and CHIP‑BCIS3 to CHAMPION‑AF, SPIRIT‑HF, PRO‑TAVI, PROTECT H2H and the latest tricuspid data (TRILUMINATE, TRI‑FR, TRISCEND II), each chapter reviews trial design, results and real‑world impact on patient selection, device strategy and heart‑team decision‑making.
Each short chapter reviews trial design, main results and how the data should influence patient selection, device strategy and heart‑team decision‑making. Browse the chapters below to jump straight to the late‑breaking trial most relevant to your practice.
Editor: Mirjam Boros
Videographer: Mike Knight
This independent series is produced by Radcliffe Cardiology.
More from this programme
Part 1
ACC.26 Late-breaking Wrap Up
Faculty Biographies
Nicolas M Van Mieghem
Full Professor of Interventional Cardiology
Prof Van Mieghem initially intended to train as a cardiac surgeon but decided to specialise in interventional cardiology instead, following advice from a mentor. This decision was cemented when he read the first-in-human case report of transcatheter aortic valve implantation (TAVI) in Circulation by Alain Cribier in 2002. Prof Van Mieghem believes that great cardiologist genuinely cares for their patients. He names Gary Roubin, Dr Manu Malbrain and Professor Patrick Serruys among his mentors.
Academic History
Prof. Nicolas M. Van Mieghem completed his medical training at the Catholic University of Leuven (Belgium), where he earned both his medical degree and his specialist degree in cardiology. During his time in Leuven, he developed a strong interest in cardiovascular medicine, particularly in the emerging field of minimally invasive cardiac interventions. After finishing his core medical and cardiology training, he pursued multiple advanced…
Azeem Latib
Section Head of Interventional Cardiology
Dr Mohamed Azeem Latib was born and raised in South Africa, where he also completed his early medical training. He later advanced his clinical and professional career internationally. He now resides in New York City, where he serves as the Section Head and Director of Interventional Cardiology and the Director of Structural Heart Interventions at the Montefiore-Einstein Center for Heart & Vascular Care. His career has spanned multiple countries and premier cardiovascular institutions.
Academic History
Dr Latib earned his Bachelor of Medicine, Bachelor of Surgery (MB BCh) from the University of the Witwatersrand in Johannesburg, South Africa, in 1995. He completed a fellowship with the College of Physicians of South Africa in 2002 and received his certificate in cardiology in 2005.
He pursued advanced subspecialty training in Europe, completing a Master’s degree in Interventional Cardiology at the San Raffaele Scientific Institute and University…
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