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Reversal Agents

Reversal Strategies For Non-Vitamin K Antagonist Oral Anticoagulants
Specific Antidotes For Bleeding Associated With Direct Oral Anticoagulants
Single-Dose Ciraparantag Safely And Completely Reverses Anticoagulant Effects Of Edoxaban
Managing Reversal Of Direct Oral Anticoagulants
Reversal Strategies For Non-Vitamin K Antagonist Oral Anticoagulants
Specific Antidotes For Bleeding Associated With Direct Oral Anticoagulants
Single-Dose Ciraparantag Safely And Completely Reverses Anticoagulant Effects Of Edoxaban
Managing Reversal Of Direct Oral Anticoagulants

Reversal Agents - Selected Papers

  • A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial Demonstrating Reversal of Edoxaban-Induced Anticoagulation in Healthy Subjects By Andexanet Alfa (PRT064445), a Universal Antidote for Factor Xa (fXa) Inhibitors
    Crowther M, Levy GG, Lu G, et al. Blood 2014;124:4269.
  • Reversal of Direct Oral Anticoagulants: Current Status and Future Directions
    Weitz JI. Semin Respir Crit Care Med 2017;38:40–50.
  • Managing reversal of direct oral anticoagulants in emergency situations
    Ageno W, Buller HR, Falanga A, et al. Thromb Haemost 2016;116:1003–10.
  • When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH
    Levy JH, Ageno W, Chan NC, et al. J Thromb Haemost 2016;14:623–7.
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