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Author(s): Jonathan S Steinberg , David Slotwiner Added: 3 years ago
Electrical Remodelling Evidence Supporting Atrial Remodelling The concept of electrical remodelling was first introduced in 1995 simultaneously by Wijffels et al.1 and Morillo et al.2 who demonstrated that once sustained atrial fibrillation (AF) was induced in goats, or rapid atrial pacing was performed in dogs, physiological changes occurred that favoured the maintenance of AF.3 This led to the… View more

Electrophysiology & Arrhythmia
Author(s): Niels Voigt , Dobromir Dobrev Added: 3 years ago
Atrial fibrillation (AF) is common and is associated with significant cardiovascular morbidity and mortality, with stroke being the most critical complication.1,2 Drugs presently used for AF therapy have major limitations, including incomplete efficacy and risks of life-threatening proarrhythmic events (antiarrhythmic drugs) and bleeding complications (anticoagulants).3 Non-pharmacological… View more

Heart Failure

Electrophysiology & Arrhythmia
AHA 21 SMART-CRT: Effects of AV Optimization on CRT Outcomes
Author(s): Michael R Gold Added: 2 years ago
In this video, Dr Michael R Gold (Medical University of South Carolina, Charleston, SC, US) shares the primary results of the Smart-CRT Trial. The study investigated the efficacy of an atrioventricular optimization algorithm to improve reverse remodeling among patients undergoing cardiac resynchronization therapy (CRT) in the presence of interventricular electrical delay. Discussion Points… View more

Electrophysiology & Arrhythmia
Atrial Fibrillation Structural Substrates: Aetiology, Identification and Implications
Author(s): Ahmed M Al-Kaisey , Ramanathan Parameswaran , Jonathan M Kalman Added: 3 years ago
AF is the most common sustained cardiac rhythm disorder and is associated with increased morbidity and mortality. Since the first description of AF initiation by triggers from pulmonary veins sleeves, pulmonary vein isolation (PVI) has become the standard ablation strategy in patients with AF.1 However, freedom from the arrhythmia, particularly in non-paroxysmal AF, remains suboptimal, and it is… View more

Electrophysiology & Arrhythmia
Obesity and AF
Author(s): Ahmed M Al-Kaisey , Jonathan M Kalman Added: 2 years ago

Electrophysiology & Arrhythmia

Prevention & Chronic Conditions
Author(s): Henry Chubb , John Whitaker , Steven E Williams , et al Added: 3 years ago
Atrial Septal Defects and Patent Foramen Ovale Nomenclature The atrial septum is a complex structure, with the true septum comprised of two layers containing a potential flap valve. The septum primum extends from caudal to cranial within the atria, on the left side of the septum secundum. The septum secundum is a crescent-shaped infolding of the atrial roof, extending from the anterosuperior… View more

Electrophysiology & Arrhythmia

Heterogeneous Populations
Author(s): Geoffrey F Lewis , Michael R Gold Added: 3 years ago
Since the introduction of CRT more than 20 years ago, its role in mild to severe systolic heart failure has become well established. CRT has been shown to decrease mortality, reduce heart failure hospitalisations and improve functional status in patients with NYHA class II–IV heart failure and QRS prolongation, most commonly with LBBB pattern.1 One of the major limitations of CRT implementation… View more

Heart Failure

Electrophysiology & Arrhythmia
Author(s): Jagmeet P Singh Added: 3 years ago
Cardiac resynchronisation therapy (CRT) has achieved widespread approval as a safe and efficient therapeutic strategy for medically refractory congestive heart failure (CHF). The standard indications for CRT include patients with advanced heart failure and evidence of systolic dysfunction (ejection fraction [EF] ≤35%), conduction tissue disease (QRS duration ≥120ms) and marked cardiac symptoms … View more

Heart Failure

Electrophysiology & Arrhythmia
Clinical Utility of Body Surface Potential Mapping in CRT Patients
Author(s): Ksenia Sedova , Kirill Repin , Gleb Donin , et al Added: 2 years ago

Imaging & Diagnostics

Heart Failure
Author(s): Philippe Chevalier Added: 3 years ago
Atrial fibrillation (AF), characterised by rapid and irregular activation of the atrium, is the most common arrhythmia in clinical practice, and 2.3 million people in North American and 4.5 million people in the EU are estimated to have paroxysmal or persistent AF.1 An estimated 0.4–1% of the general population are affected with AF,1 with prevalence increasing to nearly 10% in the octogenarian… View more

Electrophysiology & Arrhythmia