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Author(s): Alexandre FR Stewart , Robert Roberts Added: 3 years ago
Coronary artery disease (CAD) remains the most common disease and the leading cause of death, with a strong genetic risk. Clinical trials have documented that modification of known risk factors can prevent 30–40 % of CAD.1 However, epidemiologic studies have shown that genetic risk accounts for approximately 50 % of CAD.2 If the aim is to prevent CAD in this century, it will require comprehensive… View more

Vascular Disease and Surgery

Prevention & Chronic Conditions
Author(s): A John Camm , Bernard J Gersh , Demosthenes G Katritsis Added: 3 years ago
Inherited arrhythmias comprise a group of disorders with inherited susceptibility to arrhythmias and conduction disturbances due to mutations in genes mainly encoding the Na+, and K+ channels, and other arrhythmogenic mechanisms such as those linked to Ca++ transport (Table 1).1 The majority of heritable cardiomyopathies and channelopathies are associated with disease-susceptibility genes… View more

Electrophysiology & Arrhythmia
Author(s): Hillel A Steiner , Yonathan Hasin Added: 3 years ago
Sudden cardiac death (SCD) remains a public health problem of immense magnitude, afflicting an estimated 300,000 persons per year in the US.1 SCD, defined as death occurring within one hour from symptom-onset, is associated with ischemic heart disease in 80% of cases. Approximately one-third of cases are the result of an acute occlusion of an epicardial coronary artery.2 Some 50% of the mortality… View more

Electrophysiology & Arrhythmia

Prevention & Chronic Conditions
Author(s): Saagar Mahida Added: 3 years ago
Atrial fibrillation (AF) is a highly prevalent arrhythmia that represents an important burden on healthcare systems. The presence of AF is associated with an increased risk of conditions such stroke, heart failure and dementia. Further, AF is associated with increased mortality. Over the past half century, significant advances have been made in understanding the pathobiology of AF. Important… View more

Electrophysiology & Arrhythmia
Ethnic Differences in the Management of Angina
Author(s): Jack C Barton , Juan Carlos Kaski Added: 2 years ago

Prevention & Chronic Conditions
Author(s): Demosthenes G Katritsis , Bernard J Gersh , A John Camm Added: 3 years ago
Early repolarisation pattern is defined electrocardiographically by a distinct J wave or J-point elevation that is either a notch or a slur of the terminal part of the QRS entirely above the baseline, with or without ST-segment elevation. The peak of the notch or slur (Jp) should be ≥0.1 mV in two or more contiguous leads, excluding leads V1 to V2 (see Figure 1).1,2 Early repolarisation syndromes… View more

Electrophysiology & Arrhythmia
Preclinical Diagnosis and Risk Assessment of Atherosclerosis
Author(s): Giuseppe Gullace , Hassan Khalaf Added: 3 years ago
The endothelium, which was initially considered to be a semipermeable barrier separating lumen from vessel wall, is now recognised as a complex endocrine organ responsible for a variety of physiological processes vital for vascular homeostasis. These include the regulation of vascular tone, luminal diameter and blood flow; haemostasis and thrombolysis; platelet and leucocyte vessel-wall… View more

Prevention & Chronic Conditions

Demographic
AI in Cardiac Imaging and IC
Author(s): Karthik Seetharam , Sirish Shrestha , Partho P Sengupta Added: 2 years ago

Imaging & Diagnostics

Digital Health
Author(s): Dario DiFrancesco Added: 3 years ago
HCN4 (hyperpolarisation-activated, cyclic nucleotide gated 4) channels, the pore-forming α–subunits of ‘funny’ channels originally described in pacemaker cells of the sinoatrial node (SAN),1 are responsible for the early phase of diastolic depolarisation in these cells and are key determinants of pacemaker generation and control of heart rate.2–5 HCN4 channels are selectively expressed in the SAN… View more

Electrophysiology & Arrhythmia