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3 years ago
Acute coronary syndromes (ACS) are a major cause of morbidity and mortality. Despite the use of optimal medical therapy and revascularisation there remains a significant risk of vascular events. Registry data indicates a persistent risk even in patients who are event free in the first year following ACS, with as many as 1 in 5 patients suffering a vascular event in the subsequent 3 years.1
The…
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3 years ago
Non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) include unstable angina (UA) and NSTE myocardial infarction (NSTEMI), and account for one and a half million hospitalisations in the US annually. Patients with ACS are typically managed by initial medical stabilisation followed by an early invasive approach, whereby cardiac catheterisation is performed, usually within 24 hours of…
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3 years ago
Effective translation of reperfusion therapy to mortality reductions in ST-segment elevation myocardial infarction (STEMI) remains both time-critical in its implementation and dependent on optimal antithrombotic therapy. Innumerable clinical studies have explored several antithrombin and antiplatelet therapies in the immediate management of STEMI. With the wide array of the therapies now…
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The Impact of Haemorrhagic Complications on Mortality in Acute Coronary Syndromes—Implications for…
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3 years ago
Article
Added:
3 years ago
Non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) include unstable angina (UA) and NSTE myocardial infarction (NSTEMI), and account for one and a half million hospitalisations in the US annually. Patients with ACS are typically managed by initial medical stabilisation followed by an early invasive approach, whereby cardiac catheterisation is performed, usually within 24 hours of…
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3 years ago
Balloon percutaneous transluminal coronary angioplasty expands the arterial lumen, stretching and disrupting the atherosclerotic plaque and vessel wall and redistributing the atherosclerotic plaque along its longitudinal axis. The subsequent elastic recoil of the vessel wall and intimal hyperplasia may lead to restenosis in 10–30% of cases, and in about 5–6% of patients the initial balloon…
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3 years ago
Haemostasis is a complex phenomenon defined as the chain of mechanisms able to maintain the integrity of a closed, high-pressure circulatory system after vascular damage.1 Thrombogenesis represents the main process assuring haemostasis at each level of the vascular system, and its accurate regulation guarantees the correct balance between blood flow and damage repair. An uncontrolled thrombin…
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3 years ago
The spectrum of acute coronary syndromes (ACS) encompasses a broad array of clinical characteristics and risk strata, ranging from unstable angina (UA) and non-ST-segment elevation myocardial infarction (NSTEMI) to ST-segment elevation myocardial infarction (STEMI) and sudden cardiac death (SCD). In this article, UA and NSTEMI will be considered together as non-ST-segment elevation acute coronary…
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3 years ago
There has been a significant evolution in the management of patients with acute coronary syndromes (ACS), largely driven by advances in pharmacological therapy. Increased implementation of evidence-based antithrombotics and antiplatelet agents has led to improved patient outcomes.1,2 Additionally, management algorithms favouring early invasive intervention in high-risk patients are gaining…
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3 years ago
Valvular heart disease (VHD) is encountered in approximately 1% of pregnancies, significantly increasing both maternal and foetal risk.1,2 Rheumatic VHD remains the most common form in non-Western countries, whereas congenital heart disease dominates in the Western world.3,4 As increasing numbers of women with congenital heart disease are reaching childbearing age, the prevalence of women of…
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