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New Advances in the Management of Refractory Angina Pectoris
Author(s): Kevin Cheng , Ranil de Silva Added: 3 years ago
Refractory angina (RA) is defined as chronic angina-type chest pain (duration ≥ 3 months) associated with reversible ischaemia that persists despite optimal medical, interventional and surgical management.1 The clinical burden of RA is growing due to an ageing population and improved survival from coronary artery disease (CAD). Estimates suggest that in the US between 600,000 and 1.8 million… View more

Prevention & Chronic Conditions
Management of Refractory Angina Pectoris
Author(s): Kevin Cheng , Paul Sainsbury , Michael Fisher , et al Added: 3 years ago
Refractory angina (RA) is conventionally defined as a chronic condition (≥3 months in duration) characterised by angina in the setting of coronary artery disease (CAD), which cannot be controlled by a combination of optimal medical therapy, angioplasty or bypass surgery, and where reversible myocardial ischaemia has been clinically established to be the cause of the symptoms.1 In clinical… View more

Heart Failure

Prevention & Chronic Conditions
Conceptual Framework of Collateral-promoting Therapy for Coronary Artery Disease
Author(s): Masatoshi Fujita Added: 3 years ago
Despite remarkable advances in revascularisation procedures such as percutaneous coronary intervention (PCI) and coronary bypass graft surgery (CABG), a considerable number of patients with intractable angina are not candidates for these procedures. Coronary collateral circulation (CCC) is an alternative blood-conveying circuit to potentially ischaemic myocardium. Promotion of CCC is a… View more

Prevention & Chronic Conditions
Author(s): Udho Thadani Added: 3 years ago
Non-obstructive lesions are lipid-rich and soft in consistency and the endothelium overlying these lesions is prone to fissuring and disruption. The exact mechanism of plaque-endothelial surface disruption remains elusive. Several mechanisms, including an active inflammatory process, have been implicated. The fissured endothelium exposes the atheromatous material inside the vessel wall to the… View more

Prevention & Chronic Conditions
‘Primary’ Microvascular Angina
Author(s): Gaetano Antonio Lanza , Juan Carlos Kaski Added: 3 years ago
Obstructive coronary atherosclerosis and its complications (e.g. coronary thrombosis) are considered to be the most common causes of myocardial ischaemia. However, up to 50% of stable angina patients undergoing diagnostic coronary angiography and 10–15% of those presenting with acute coronary syndrome (ACS) are found to have normal or ‘near-normal’ coronary arteries.1,2 A large body of data… View more

Prevention & Chronic Conditions
Author(s): Philip A Poole-Wilson Added: 3 years ago
Angina pectoris is a symptom that is usually, in the developed world, caused by obstruction to the coronary arteries by the enlargement of atheromatous lesions; there are other causes. The symptom can limit lifestyle, but more importantly is a repetitive reminder to the patient of the presence of heart disease, causing continual anxiety because of the belief that angina is the portent of early… View more

Prevention & Chronic Conditions
Author(s): Philip A Poole-Wilson Added: 3 years ago
Angina pectoris is a symptom that is usually, in the developed world, caused by obstruction to the coronary arteries by the enlargement of atheromatous lesions; there are other causes. The symptom can limit lifestyle, but more importantly is a repetitive reminder to the patient of the presence of heart disease, causing continual anxiety because of the belief that angina is the portent of early… View more

Prevention & Chronic Conditions

MI/ACS
Author(s): Thomas J Povsic Added: 3 years ago
The potential of physiological regeneration offered by stem-cell-mediated therapy has captured the imagination of both the public and the scientific community. This is especially true for the cardiovascular and nervous systems, which have long been considered terminally differentiated and post-mitotic with minimal capacity for regeneration and repair. While the ability of embryonically derived… View more

Vascular Disease and Surgery

MI/ACS
Microvascular Angina: Diagnosis and Management
Author(s): Haider Aldiwani , Suzan Mahdai , Ghaith Alhatemi , et al Added: 2 years ago

Intervention