Although atrial fibrillation typically occurs in elderly subjects and particularly in those with longstanding hypertension or heart failure, younger individuals may be affected as well.1 In the latter population, a genetic basis has long been suspected.2 Hui-Nam Pak and colleagues from the Yonsei University Health System in Seoul, South Korea remind us that genetic susceptibility loci for atrial fibrillation identified by genome-wide association studies in a European database showed ethnic differences in the Asian population. They therefore explored novel atrial fibrillation susceptibility variants in Korean patients with early-onset atrial fibrillation, i.e. at age 60 or younger, who underwent catheter ablation. They report the results of their genome-wide association study performed in 672 cases and 3700 controls in their article ‘Koreanatrial fibrillationnetwork genome-wide association study...
Lüscher TF et al. Eur Heart J. 2017;38:2573-2575.