Risk factors and consequences of atrial fibrillation: genetics, blood pressure, working hours, and cognitive decline


Although atrial fibrillation typically occurs in elderly subjects and particularly in those with longstanding hypertension or heart failure, younger individuals may be affected as well.1 In the latter population, a genetic basis has long been suspected.2 Hui-Nam Pak and colleagues from the Yonsei University Health System in Seoul, South Korea remind us that genetic susceptibility loci for atrial fibrillation identified by genome-wide association studies in a European database showed ethnic differences in the Asian population. They therefore explored novel atrial fibrillation susceptibility variants in Korean patients with early-onset atrial fibrillation, i.e. at age 60 or younger, who underwent catheter ablation. They report the results of their genome-wide association study performed in 672 cases and 3700 controls in their article ‘Koreanatrial fibrillationnetwork genome-wide association study...

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Lüscher TF et al. Eur Heart J. 2017;38:2573-2575.