The Bifurcation Center
Your center for bifurcation knowledge
Coronary bifurcations present complex challenges for interventional cardiologists.
The Bifurcation Center brings clarity, evidence and expert understanding to every step of bifurcation PCI.
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Welcome to The Bifurcation Center
Recent Videos
Prof Goran Stankovic speaks with Prof Bruno Scheller, a pioneer of DCB therapy, about the evolving role of DCB in left main and coronary bifurcation PCI.
In part 2, Prof Goran Stankovic and Prof Bruno Scheller review emerging evidence for blended and puristic DCB strategies in bifurcation PCI.
Coming soon: Prof Goran Stankovic and Prof Francesco Burzotta come together for a new conversation in this series, sharing perspectives and experience on coronary bifurcation treatment.
Coming soon: Prof Goran Stankovic and Prof Francesco Burzotta come together for a new conversation in this series, sharing perspectives and experience on coronary bifurcation treatment.
Key Congress Highlights
This symposium explores evolving best practices in coronary bifurcation treatment, highlighting drug-coated balloons, angio-based FFR and side-branch optimisation.
This EuroPCR 2025 session helps you decide when to use a drug-coated balloon instead of a stent, with practical insights on bifurcations, dissections and provisional PCI strategies.
Watch this EuroPCR 2025 session for concise insights on DCB vs DES in bifurcation lesions, the POT–kissing–POT technique and wire-free angio-based FFR – and what they mean for daily practice.
Chaired by Prof Goran Stankovic, this session combines Visible Heart Lab insights with clinical cases and emerging evidence for drug-coated balloons in coronary bifurcation treatment.
This EuroPCR 2024 session highlights provisional stenting with Resolute Onyx DES, beating-heart bifurcation techniques, and wire-free, hyperemia-free FFRangio for physiological lesion assessment.
Bifurcation Techniques
Provisional stenting is a treatment philosophy – rather than a technique – that meets the objective of bifurcation lesion treatment with a single stent whenever possible.
Guidance from the 16th EBC consensus1
- Single stent, less metal
- Keep it simple and safe
- Stepwise approach emphasising versatility based upon bifurcation lesion complexity
1 Albiero R, Burzotta F, Lassen JF, et al. Treatment of coronary bifurcation lesions, part I: implanting the first stent in the provisional pathway. The 16th expert consensus document of the European Bifurcation Club. EuroIntervention 2022;18:e362–76.
Explore more bifurcation techniques:
T and TAP in Practice | Culotte Overview | DK Crush | Visible Heart Lab
The T and small protrusion (TAP) technique is a modification of provisional T-stenting aimed at optimising implantation of a second stent in bifurcated coronary lesions treated using the provisional pathway.1
The stent from the SB is intentionally positioned with a small (1–2 mm) protrusion in the MV, to fully cover the ostium area and is deployed simultaneously with a balloon positioned in the MV.1
TAP- stenting was developed and reported by Burzotta et al in 2007, with the aim of improving the T-stenting technique to ensure full ostial coverage, where bifurcation geometry prevents perfect alignment of stents and to provide a strategy to facilitate final KBI.
1 Burzotta F, Džavík V, Ferenc M, et al. Technical aspects of the T And small Protrusion (TAP) technique. EuroIntervention 2015;11 Suppl V:V91-5.
Explore more bifurcation techniques:
Provisional Stenting | Culotte Overview | DK Crush | Visible Heart Lab
Culotte may be practiced in both intentional double-stenting procedures and in provisional procedures when a second stent is required. The main limitation of Culotte stenting is the possible presence of major mismatch between the size of the proximal MV and SB. Thus, two aspects are recognised as critical, the stent platform selection and the application of POT during the procedural flow.1
Culotte
- Is associated with high procedural success and relatively low risk of angiographic restenosis
- In bifurcations with narrow angles
- In bifurcations with similar diameters
1Lassen JF, Holm NR, Banning A, et al. Percutaneous coronary intervention for coronary bifurcation disease: 11th consensus document from the European Bifurcation Club. EuroIntervention 2016;12:38–46.
Explore more bifurcation techniques:
Provisional Stenting | T and TAP in Practice | DK Crush | Visible Heart Lab
This technique is a true intentional upfront two stent approach in the treatment of complex bifurcation lesions (CBL) with extensive side branch disease. It will always end with two stents and maximum metallic coverage of the bifurcation.
DK Crush belongs to the “S” family of the MADS-2 classification of bifurcation stenting techniques and is always finalised with 2 stents in the bifurcation. The first stent is implanted in the side branch.
Lassen JF, Albiero R, Johnson TW, et al. Treatment of coronary bifurcation lesions, part II: implanting two stents. The 16th expert consensus document of the European Bifurcation Club. EuroIntervention 2022;18:457–70.
Explore more bifurcation techniques:
Provisional Stenting | T and TAP in Practice | Culotte Overview | Visible Heart Lab
- Exclusive collaboration with Medtronic and ongoing partnerships with the world's leading bifurcation clubs including EBC, JBC, KBC and LATAM, and now emerging US
- Development of educational materials leveraging technique and our unique stent portfolio characteristics (Bifurcation Exploration, Speaker decks and Visible Heart footage)
- Unparalleled multi-modality imaging gives ICs never before seen looks into techniques they perform in their daily practice
Explore more bifurcation techniques:
Provisional Stenting | T and TAP in Practice | Culotte Overview | DK Crush
Webinar Series
This webinar replay lets you assess side-branch intervention in provisional stenting, review KISS trial implications and learn optimal KBI technique with insights from the Visible Heart lab model.
This webinar replay lets you review evidence for DCB in bifurcations, learn stepwise and hybrid DCB strategies, and understand vessel prep, delivery, and result assessment.
View this webinar on-demand to master bifurcation stenting using Visible Heart Lab insights, review pitfalls in provisional and two-stent techniques and learn complication prevention and management.
Watch this webinar to explore the evidence for DCB use in coronary bifurcations, learn vessel preparation and therapy delivery, and understand how to use angiography-based physiology to optimise bifurcation PCI.
Left Main Bifurcations
Watch this PCR Webinar on-demand to explore the EBC Main trial design and key findings, review representative cases and discuss the applicability of the results to everyday practice.
Access this PCR Webinar on-demand to review left main PCI complications, learn strategies to reduce risk and gain practical techniques for managing issues when they arise.
This webinar replay helps you assess left main 0,0,1 bifurcation morphology, understand treatment options for isolated ostial LCx lesions and learn optimisation using intracoronary imaging and physiology.
This webinar replay reviews optimal DK Crush steps, highlights potential pitfalls using Visible Heart and intracoronary imaging insights, and teaches complication prevention and management.
Watch this webinar on-demand to understand left main in-stent restenosis, explore treatment options and learn DCB use for bifurcation restenosis.
Key Trials
Percutaneous coronary intervention for bifurcation coronary lesions using optimised angiographic guidance: the 18th consensus document from the European Bifurcation Club
Burzotta F, Louvard Y, Lassen JF, et al. EuroIntervention 2024;20:e915–26.
The 17th expert consensus document of the European Bifurcation Club - techniques to preserve access to the side branch during stepwise provisional stenting
Pan M, Lassen JF, Burzotta F, et al. EuroIntervention 2023;19:26–36.
Treatment of coronary bifurcation lesions, part I: implanting the first stent in the provisional pathway. The 16th expert consensus document of the European Bifurcation Club
Albiero R, Burzotta F, Lassen JF, et al. EuroIntervention 2022;18:e362–76.
Treatment of coronary bifurcation lesions, part II: implanting two stents. The 16th expert consensus document of the European Bifurcation Club
Lassen JF, Albiero R, Johnson TW, et al. EuroIntervention 2022;18:457–70.
Explore more publications:
Drug-Coated Balloon Publications | Left Main Bifurcation Publications
Percutaneous coronary intervention for bifurcation coronary lesions: the 15th consensus document from the European Bifurcation Club
Burzotta F, Lassen JF, Lefèvre T, et al. EuroIntervention 2021;16:1307–17.
CTO and bifurcation lesions: an expert consensus from the European Bifurcation Club and EuroCTO Club
Lefèvre T, Pan M, Stankovic G, et al. JACC Cardiovasc Interv 2023;16:2065–82.
European Bifurcation Club white paper on stenting techniques for patients with bifurcated coronary artery lesions
Burzotta F, Lassen JF, Louvard Y, et al. Catheter Cardiovasc Interv 2020;96:1067–79.
Explore more publications:
Drug-Coated Balloon Publications | Left Main Bifurcation Publications
Drug-coated balloon angioplasty of the side branch during provisional stenting: the multicenter randomized DCB-BIF trial
Gao X, Tian N, Kan J, et al. J Am Coll Cardiol 2025;85:1–15.
Sirolimus-coated versus paclitaxel-coated balloons for bifurcated coronary lesions in the side branch: the SPACIOUS trial
Zhou Y, Hu Y, Zhao X, et al. EuroIntervention 2025;21:e307–17.
A prospective randomized open-label trial of sirolimus versus paclitaxel-coated balloons for the side branch of de novo coronary bifurcation lesion
Gao Q, Liu C, Xu G, et al. J Thorac Dis 2025;17:10869–79.
One-year clinical outcomes of stentless percutaneous coronary intervention using drug-coated balloon for true bifurcation lesions
Tanaka Y, Nozaki Y, Kitani S, et al. J Soc Cardiovasc Angiogr Interv 2025;4:103941.
Indications for use of drug-coated balloons in coronary intervention: Academic Research Consortium Position Statement
Fezzi S, Serruys PW, Cortese B, et al. J Am Coll Cardiol 2025;86:1170–202.
Explore more publications:
EBC Consensus Documents | Left Main Bifurcation Publications
Drug-coated balloon-based treatment of left main true bifurcation lesion
Her AY, Kim TH, Shin ES, et al. Catheter Cardiovasc Interv 2025;105:1024–31.
A comparison of a drug coated balloon with drug eluting stent strategy for treating coronary bifurcation lesions
Corballis N, Merinopoulos I, Bhalraam U, et al. Catheter Cardiovasc Interv 2026;107:3–14.
Bifurcation PCI with a hybrid strategy with drug- eluting balloons versus a stepwise provisional two- stent strategy: rationale and design of the hybrid DEB study
Dillen DMM, Vlaar PJ, Vermeer AJE, et al. Am Heart J 2023;266:168–75.
Drug-coated balloons for coronary bifurcation lesions
Fezzi S, Scheller B, Rissanen TT, et al. EuroIntervention 2025;21:e1177–97.
Drug-coated balloon treatment in coronary artery disease: recommendations from an Asia-Pacific Consensus Group
Her AY, Shin ES, Bang LH, et al. Cardiol J 2021;28:136–49.
Explore more publications:
EBC Consensus Documents | Left Main Bifurcation Publications
Drug coated balloons and their role in bifurcation coronary angioplasty: appraisal of the current evidence and future directions
Rathore S, Tehrani S, Prvulovic D, et al. Expert Rev Med Devices 2020;17:1021–33.
Drug-coated balloons for de novo non-aorto-ostial and coronary bifurcation lesions: a systematic review and meta-analysis
Mariscal ES, Slotwiner A, Karam B, et al. J Soc Cardiovasc Angiogr Interv 2025;4(12):103944.
Drug-coated balloons versus non-coated balloons for side branch treatment in bifurcation lesions: a systematic review and meta-analysis
Rocchetti M, Tua L, Cereda A, et al. Catheter Cardiovasc Interv 2025;106:530–9.
Application of drug-coated balloons in complex high risk and indicated percutaneous coronary interventions
Somsen YBO, Rissanen TT, Hoek R, et al. Catheter Cardiovasc Interv 2025;105:494–516.
Explore more publications:
EBC Consensus Documents | Left Main Bifurcation Publications
The European Bifurcation Club Left Main Study (EBC MAIN): rationale and design of an international, multicentre, randomised comparison of two stent strategies for the treatment of left main coronary bifurcation disease
Chieffo A, Hildick-Smith D. EuroIntervention 2016;12:47–52.
A large, prospective, multicentre study of left main PCI using a latest-generation zotarolimus-eluting stent: the ROLEX study
Tarantini G, Fovino LN, Varbella F, et al. EuroIntervention 2023;18:e1108–19.
Stepwise provisional versus systematic dual-stent strategies for treatment of true left main coronary bifurcation lesions
Arunothayaraj S, Egred M, Banning AP, et al. Circulation 2025;151:612–22.
Left main bifurcation stenting: impact of residual ischaemia on cardiovascular mortality
Wang HY, Zhang R, Dou K, et al. Eur Heart J 2023;44:4324–36.
Optimal minimal stent area and impact of stent underexpansion in left main up-front 2-stent strategy
Kim JH, Kang DY, Ahn JM, et al. Circ Cardiovasc Interv 2024;17:e013006.
Explore more publications:
EBC Consensus Documents | Drug-Coated Balloon Publications
Impact of calcification location in the left main coronary artery bifurcation on short-term prognosis after left main stenting
Sasaki K, Sawayama Y, Taninobu N, et al. Circ J 2025;89:1129–36.
OCT-guided distal left main bifurcation PCI: mid-term outcomes from a multicenter South-Asian registry
Kumar P, Najmy S, Rajendran M, et al. Catheter Cardiovasc Interv 2026;107:477–84.
Real-world experience and outcomes with percutaneous coronary intervention for protected versus unprotected left main coronary artery disease: insights from the Veteran Affairs Clinical Assessment Reporting and Tracking Program
Gonzalez PE, Hebbe A, Hussain Y, et al. Am J Cardiol 2024;222:39–50.
Long-term clinical outcomes of percutaneous coronary intervention for ostial left main coronary artery disease
Sui Y, Qian J, Guan C, et al. EuroIntervention 2023;18:1446–55.
Explore more publications:
EBC Consensus Documents | Drug-Coated Balloon Publications
Chinese guidelines for percutaneous coronary intervention in patients with left main bifurcation disease
Han Y. Eur Heart J 2023;44:709–10.
Antithrombotic therapy after percutaneous coronary intervention of bifurcation lesions
Zimarino M, Angiolillo DJ, Dangas G, et al. EuroIntervention 2021;17:59–66.
Definitions and standardized endpoints for treatment of coronary bifurcations
Lunardi M, Louvard Y, Lefèvre T, et al. EuroIntervention 2023;19:e807–31.
Physiological approach for coronary artery bifurcation disease: position statement by Korean, Japanese, and European Bifurcation Clubs
Lee HS, Kim U, Yang S, et al. JACC Cardiovasc Interv 2022;15:1297–309.
Comparison of stent geometry achieved by different side-branch ballooning techniques for bifurcation provisional stenting: The CRABBIS Trial
Bianchini F, Romagnoli E, Aurigemma C, et al. JACC Cardiovasc Interv 2025;18:1103–15.
Final kissing balloon dilatation in patients with coronary bifurcation lesions treated with an upfront provisional stenting strategy
De Filippo O, Kang J, Bruno F, et al. EuroIntervention 2025;21:e318–28.
Benefit of systematic "jailed wire" technique for bifurcation provisional stenting. A CABRIOLET substudy
Dérimay F, Mercier A, Aminian A, et al. Can J Cardiol 2025;41:871–7.
Jailed pressure wire technique for coronary bifurcation lesions: structural damage and clinical outcomes
Hidalgo F, González-Manzanares R, Ojeda S, et al. Rev Esp Cardiol (Engl Ed) 2023;76:531–8.
Multimodal comparisons of results achieved by different side branch ballooning techniques for bifurcation provisional stenting
Bianchini F, Cangemi S, DeVos A, et al. Circ Cardiovasc Interv 2023;16:e012908.
Proximal optimization technique and percutaneous coronary intervention for left main disease: POTENTIAL-LM
Volet C, Puricel S, Cook ST, et al. Catheter Cardiovasc Interv 2024;103:417–24.
Szabo 2-stent technique for coronary bifurcation lesions: procedural and short-term outcomes
Yang H, Qian J, Huang Z, Ge J. BMC Cardiovasc Disord 2020;20:325.
OCT or angiography guidance for PCI in complex bifurcation lesions
Holm NR, Andreasen LD, Neghabat O, et al. N Engl J Med 2023;389:1477–87.
OCT-guided vs angiography-guided coronary stent implantation in complex lesions: an ILUMIEN IV substudy
Ali ZA, Landmesser U, Maehara A, et al. J Am Coll Cardiol 2024;84:368–78.
Guiding intervention for complex coronary lesions by optical coherence tomography or intravascular ultrasound
Kang DY, Ahn JM, Yun SC, et al. J Am Coll Cardiol 2024;83:401–13.
Unintended deformation of stents during bifurcation PCI: an OCTOBER trial substudy
Andreasen LN, Neghabat O, Laanmets P, et al. JACC Cardiovasc Interv 2024;17:1106–15.
Impact of intravascular ultrasound for coronary bifurcations treated with last-generation stents: insights from the ULTRA-BIFURCAT registry
Bruno F, Choi KH, De Filippo O, et al. Eur Heart J Qual Care Clin Outcomes 2025;11:747–55.
Routine intracoronary imaging-guided left main coronary intervention
Murasato Y, Nakashima H, Sugino H, et al. Sci Rep 2025;15:9504.
Intravascular imaging for percutaneous coronary intervention on bifurcation and unprotected left main lesions: a systematic review and meta-analysis
Zito A, Burzotta F, Aurigemma C, et al. Open Heart 2025;12:e003026.
Computational simulations of coronary artery bifurcation stenting using realistic plaque distribution and materials
Wu W, Zhao S, Bhat RR, et al. Sci Rep 2025;15:34242.
Patient-specific computational simulation of coronary artery bifurcation stenting
Zhao S, Wu W, Samant S, et al. Sci Rep 2021;11:16486.
3D reconstruction of coronary artery bifurcations from coronary angiography and optical coherence tomography: feasibility, validation, and reproducibility
Wu W, Samant S, de Zwart G, et al. Sci Rep 2020;10:18049.
3D reconstruction of coronary artery bifurcations from intravascular ultrasound and angiography
Wu W, Oguz UM, Banga A, et al. Sci Rep 2024;14:6612.
Virtual 2-stent bifurcation percutaneous coronary intervention using the fractional flow reserve computed tomography planner
Ohashi H, Zivelonghi C, Seki R, et al. JACC Cardiovasc Interv 2023;16:863–4.
Impact of bifurcation lesions on outcomes after FFR-guided PCI or CABG
Burzotta F, Louvard Y, Lassen JF, et al. Circ Cardiovasc Interv 2025;18:e014610.
Development of a novel BifurcAID risk score to predict MACE following coronary true bifurcation intervention
Minatoguchi S, Koshy AN, Vengrenyuk Y, et al. JACC Cardiovasc Interv 2025;18:705–16.
A new scoring system predicting side-branch occlusion in patients undergoing left main bifurcation intervention: the LM V-RESOLVE score
He J, Cai Z, Wang HY, et al. Can J Cardiol 2024;40:1619–31.
Risk assessment of side branch compromise after coronary bifurcation stenting - a substudy of the 3D-OCT Bifurcation Registry
Akase H, Okamura T, Nagoshi R, et al. Circ J 2024;88:959–69.
Impact of bifurcation angle on side branch occlusion in provisional bifurcation percutaneous coronary intervention: analysis from the PROGRESS-BIFURCATION registry
Mutlu D, Selim Ser O, Strepkos D, et al. Am J Cardiol 2025;253:41–8.
Long-term prognosis after coronary bifurcation PCI-a nationwide observational study
Katona A, von Koch S, Andell P, et al. PLoS One 2025;20:e0317628.
Differential prognosis of true bifurcation lesions according to left main versus non-left main location and treatment strategy
Choi KH, Nam CW, Bruno F, et al. J Am Heart Assoc 2025;14:e037657.
Bifurcation functional significance score as predictor of mortality: a validating study
Vassilev D, Mileva N, Collet C, et al. Sci Rep 2021;11:24308.
One year clinical outcomes in patients with coronary bifurcation lesions: results from the Resolute Onyx bifurcation study
Price M, Boutis L, Kirtane A, et al. JACC 2021;77:965.
A technology evaluation of the Onyx Frontier drug-eluting stent
Leone PP, Assafin M, Scotti A, et al. Expert Opin Drug Deliv 2023;20:689–701.
Long-term outcomes of true versus nontrue coronary bifurcation lesions treated with bioresorbable polymer sirolimus-eluting ultimaster stent under intravascular imaging guidance
Matsuna N, Kuramitsu S, Tadano Y, et al. Am J Cardiol 2025;239:57–63.
Dedicated bifurcation stents for coronary bifurcation lesions: a systematic review and meta-analysis of randomized-controlled trials
Mohamed MO, Mamas MA, Nagaraja V, et al. J Invasive Cardiol 2019;31:E344–55.
Clinical outcome after percutaneous coronary intervention with drug-eluting stent in bifurcation and nonbifurcation lesions: a meta-analysis of 23 981 patients
Burzotta F, Annone U, Paraggio L, et al. Coron Artery Dis 2020;31:438–45.