Radial Artery Dilatation to Improve Access and Lower complication rates during coronary angiography (RADIAL): A Randomized Controlled Trial



To explore the use of prolonged occlusion flow mediated dilatation (PO-FMD) to dilate the radial artery prior to cannulation to increase cannulation success, reduce puncture attempts and reduce access site complications in transradial coronary angiography.


1156 patients undergoing transradial coronary angiography were randomized into PO-FMD and sham PO-FMD groups. PO-FMD was achieved by a 10 minute inflation of a blood pressure cuff on the arm to above systolic pressure, followed by deflation with resultant radial artery dilation. In the sham PO-FMD group the cuff was not inflated. Operators were blinded to the intervention. 580 patients were randomized to the sham PO-FMD group and 576 to the PO-FMD group. Cannulation failure was reduced with PO-FMD with cannulation failure rates of 2.7% in the PO-FMD group and 5.8% in the sham PO-FMD group (p=0.01).The number of puncture attempts were reduced with the use of PO-FMD, with a median of 1 attempt in the PO-FMD group and 2 in the sham PO-FMD group (p<0.001). Radial artery pulsation loss (RAPL) was reduced with PO-FMD with 1.4% in the PO-FMD group and 3.8% in the sham PO-FMD group (p=0.02).


PO-FMD reduces cannulation failure rates, decreases puncture attempts, and decreases RAPL during transradial coronary angiography.

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Doubell J, et al EuroIntervention 2019. (Epub ahead of print).