Pulmonary Arterial Hypertension
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Pulmonary arterial hypertension (PAH) is a chronic and life-threatening disease characterised by progressive vascular remodelling that leads to increased pulmonary vascular resistance, right ventricular heart failure and death.
Load morePulmonary arterial hypertension (PAH) is a chronic and life-threatening disease characterised by progressive vascular remodelling that leads to increased pulmonary vascular resistance, right ventricular heart failure and death.
PAH is defined by >25 mmHg increase in pulmonary arterial blood pressure and a pulmonary capillary wedge pressure of 15 mmHg. If left untreated, PAH is fatal; it has a survival rate of just 34% after 5 years. Current therapies include stimulating the nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP) axis, improving the prostacyclin pathway or inhibiting the endothelin pathway.
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Julia Sikorska, James UprichardEuropean Cardiology Review 2017;12(1):40–5.DOI: https://doi.org/10.15420/ecr.2017:11:2
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Jelena Celutkiene, Mindaugas Balčiūnas, Denis Kablučko, et alCardiac Failure Review 3(1):56–61.DOI: https://doi.org/10.15420/cfr.2016:23:2
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Rebecca L Attridge, Rebecca D Moote, Deborah J Levine, et alUS Cardiology Review 2016;10(2):78–84DOI: https://doi.org/10.15420/usc.2016:2:2
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A Practical Clinical Approach to the Diagnosis and Treatment of Patients with Pulmonary HypertensionBrendan P MaddenEuropean Cardiology Review 2015;10(2):102–7DOI: https://doi.org/10.15420/ecr.2015.10.2.102
