Pulmonary Arterial Hypertension
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Pulmonary arterial hypertension (PAH) is a chronic and life-threatening disease characterised by progressive vascular remodelling that leads to increased pulmonary vascular resistance, right ventricular heart failure and death.
Load morePulmonary arterial hypertension (PAH) is a chronic and life-threatening disease characterised by progressive vascular remodelling that leads to increased pulmonary vascular resistance, right ventricular heart failure and death.
PAH is defined by >25 mmHg increase in pulmonary arterial blood pressure and a pulmonary capillary wedge pressure of 15 mmHg. If left untreated, PAH is fatal; it has a survival rate of just 34% after 5 years. Current therapies include stimulating the nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP) axis, improving the prostacyclin pathway or inhibiting the endothelin pathway.
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Hiroshi WatanabeEuropean Cardiology Review 2018;13(1):35–7.DOI: https://doi.org/10.15420/ecr.2017:22:2
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Brett Wanamaker, Thomas Cascino, Vallerie V McLaughlin, et alArrhythmia & Electrophysiology Review 2018;7(1):43–8.DOI: https://doi.org/10.15420/aer.2018.3.2
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Saumil R Shah, Sergio Waxman, William H Gaasch, et alUS Cardiology Review 2017;11(2):72–4.DOI: https://doi.org/10.15420/ucs.2017:9:2
