ECR

Dilated Cardiomyopathy Risk in Patients with Coronavirus Disease 2019: How to Identify and Characterise it Early?

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This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.

The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a public health emergency of international concern.1 The pandemic is ongoing, and the world is faced with the urgent task of minimising the mortality associated with COVID-19.

Ethical Issues in Decision-making Regarding the Elderly Affected by Coronavirus Disease 2019: An Expert Opinion

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This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.

Nearly every country is now affected by the coronavirus disease 2019 (COVID-19) pandemic. The disease is spreading rapidly and is taxing the global healthcare system, particularly intensive care units (ICUs). Physicians are faced with ethical decisions regarding the allocation of these precious resources, especially ventilators. Although only a few of those infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) require admission to intensive care, the burden on healthcare systems is unprecedented.

A Multicentre, Open-Label, Randomised Controlled Clinical Trial to Assess the Efficacy and Safety of Appropriate Target Values for Lipid Management in Patients who Have Mild to Moderate Stenotic Lesions with High-Risk Plaques in Coronary Arteries: Study P

Open access
This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.

Aims: To investigate the efficacy of strict lipid management by secondary prevention high-risk criteria in preventing major cardiovascular events and progression of coronary artery stenosis in study subjects without proven history of coronary artery diseases (CAD) who have non-occlusive lesions with unstable plaques or severe calcification detected by coronary artery CT (CACT), in comparison with standard lipid management as per the primary prevention criteria.

Comorbidity Differentiation and Risk Stratification in the Elderly Patient with Polypharmacy: A Prospective Primary Care Registry on Oral Anticoagulation Therapy

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This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.

Objectives: Although polypharmacy is an accepted proxy for multi-morbidity, there has been limited attention for risk stratification among polypharmacy patients, especially in the elderly. We used the number of drug classes prescribed to determine the extent of co-morbidity and the risk of adverse outcome.

Impacts of Adipocytokines and Obesity-associated Inflammatory Markers on Apolipoprotein A-1 and B in Patients on Statin Therapy

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This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.

Background and aims: Obesity-induced chronic low-grade inflammation is causally associated with insulin resistance leading to dyslipidaemia, which is residual risks for coronary artery diseases in patients on statin therapy. The aim of this study is to clarify the impacts of adipocytokines and obesity-associated inflammatory markers on apolipoprotein (apo) A1 and B in patients on statin therapy.

Statins and Insulin Resistance

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This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.

Statins are lipid-lowering drugs that are beneficial for the cardiovascular system. However, they are associated with skeletal muscle disorders and, recently, with insulin resistance and new-onset diabetes. To date, mechanisms underlying statin-induced insulin resistance are not fully elucidated.

The goals of the study were to characterise effects of simvastatin on glucose metabolism and processes leading to the induced insulin resistance in skeletal muscle cells and mice.